The biophysical and molecular basis of intracellular pH sensing by Na /H exchanger-3 (Q37245963)

19 August 2017

The biophysical and molecular basis of intracellular pH sensing by Na /H exchanger-3 (English)

1 reference

19 August 2017

Victor Babich

1

1 reference

19 August 2017

Komal Vadnagara

series ordinal

2

1 reference

19 August 2017

Francesca Di Sole

series ordinal

3

1 reference

19 August 2017

language of work or name

English

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publication date

9 August 2013

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19 August 2017

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19 August 2017

27

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19 August 2017

11

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19 August 2017

4646-4658

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SLC9/NHE gene family, a plasma membrane and organellar family of Na⁺/H⁺ exchangers

19 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

N-myristoylation and Ca2 binding of calcineurin B homologous protein CHP3 are required to enhance Na /H exchanger NHE1 half-life and activity at the plasma membrane

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Deciphering the mechanisms of the Na /H exchanger-3 regulation in organ dysfunction.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Molecular mechanisms of acid-base sensing by the kidney

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Calcineurin homologous protein: a multifunctional Ca2 -binding protein family

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Acute regulation of renal Na /H exchanger NHE3 by dopamine: role of protein phosphatase 2A.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

The calcineurin homologous protein-1 increases Na( )/H( ) -exchanger 3 trafficking via ezrin phosphorylation

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

NHE3 regulatory complexes

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Luminal Na( )/H ( ) exchange in the proximal tubule

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Steady-state function of the ubiquitous mammalian Na/H exchanger (NHE1) in relation to dimer coupling models with 2Na/2H stoichiometry

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Ca-dependent nonsecretory vesicle fusion in a secretory cell

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Calcineurin B homologous protein 3 promotes the biosynthetic maturation, cell surface stability, and optimal transport of the Na /H exchanger NHE1 isoform

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Regulatory binding partners and complexes of NHE3.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Intracellular pH sensors: design principles and functional significance

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Solution structure of the cytoplasmic region of Na /H exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulation

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

The role of disturbed pH dynamics and the Na /H exchanger in metastasis.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Na /H exchangers: physiology and link to hypertension and organ ischemia

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Molecular physiology of intestinal Na /H exchange

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Evolutionary origins of eukaryotic sodium/proton exchangers

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Lipid- and mechanosensitivities of sodium/hydrogen exchangers analyzed by electrical methods

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Role of calcineurin B homologous protein in pH regulation by the Na /H exchanger 1: tightly bound Ca2 ions as important structural elements

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Dynamic control of cystic fibrosis transmembrane conductance regulator Cl(-)/HCO3(-) selectivity by external Cl(-)

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Diversity of the mammalian sodium/proton exchanger SLC9 gene family

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Multiple modes of regulation of Na /H exchangers.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Expression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na /H exchanger

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Calcineurin homologous protein as an essential cofactor for Na /H exchangers

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Acute regulation of proximal tubule apical membrane Na/H exchanger NHE-3: role of phosphorylation, protein trafficking, and regulatory factors

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

The Na /H antiporter cytoplasmic domain mediates growth factor signals and controls "H( )-sensing"

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Acute regulation of Na/H exchanger NHE3 by adenosine A(1) receptors is mediated by calcineurin homologous protein

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Two histidine residues in the juxta-membrane cytoplasmic domain of Na /H exchanger isoform 3 (NHE3) determine the set point

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Dopamine acutely stimulates Na /H exchanger (NHE3) endocytosis via clathrin-coated vesicles: dependence on protein kinase A-mediated NHE3 phosphorylation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Regulation of NHE3 activity by G protein subunits in renal brush-border membranes.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Adenosine inhibits the transfected Na -H exchanger NHE3 in Xenopus laevis renal epithelial cells (A6/C1).

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Giant membrane patches: improvements and applications

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Identification of cytoplasmic subdomains that control pH-sensing of the Na /H exchanger (NHE1): pH-maintenance, ATP-sensitive, and flexible loop domains

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Parathyroid Hormone and Parathyroid Hormone-related Peptide Inhibit the Apical Na /H Exchanger NHE-3 Isoform in Renal Cells (OK) via a Dual Signaling Cascade Involving Protein Kinase A and C

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Dysregulated pH: a perfect storm for cancer progression.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Massive endocytosis driven by lipidic forces originating in the outer plasmalemmal monolayer: a new approach to membrane recycling and lipid domains.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Ion fluxes in giant excised cardiac membrane patches detected and quantified with ion-selective microelectrodes

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Gbeta regulation of Na/H exchanger-3 activity in rat renal proximal tubules during development

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Na/H exchange activities in NHE1-transfected OK-cells: cell polarity and regulation

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Impaired cell volume regulation in Na( )-H exchange-deficient mutants

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Parathyroid hormone regulation of Na /H exchange in opossum kidney cells: polarity and mechanisms

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Regulation of Na /H exchange in opossum kidney cells by parathyroid hormone, cyclic AMP and phorbol esters

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Structural characterization of calcineurin B homologous protein 1.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Kinetic dissection of two distinct proton binding sites in Na /H exchangers by measurement of reverse mode reaction

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Bimodal acute effects of A1 adenosine receptor activation on Na /H exchanger 3 in opossum kidney cells

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Zoniporide: a potent and highly selective inhibitor of human Na( )/H( ) exchanger-1.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Characterization of acute inhibition of Na/H exchanger NHE-3 by dopamine in opossum kidney cells

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3804747

Modifier role of internal H in activating the Na –H exchanger in renal microvillus membrane vesicles

3 September 2018

1 reference

12 December 2020

Mutation of calmodulin-binding site renders the Na /H exchanger (NHE1) highly H( )-sensitive and Ca2 regulation-defective

1 reference

12 December 2020

Distinct structural domains confer cAMP sensitivity and ATP dependence to the Na /H exchanger NHE3 isoform

1 reference

12 December 2020

NHE3 phosphorylation at serines 552 and 605 does not directly affect NHE3 activity

1 reference

12 December 2020

Loss of calcineurin homologous protein-1 in chicken B lymphoma DT40 cells destabilizes Na /H exchanger isoform-1 protein

1 reference

12 December 2020

Increased NHE3 abundance and transport activity in renal proximal tubule of rats with heart failure

1 reference

12 December 2020

Dopamine(1) receptor, G(salpha), and Na( )-H( ) exchanger interactions in the kidney in hypertension

1 reference

12 December 2020

Characterization of a histidine rich cluster of amino acids in the cytoplasmic domain of the Na /H exchanger

1 reference

12 December 2020

Identifiers

DOI

10.1096/FJ.12-225466

1 reference

19 August 2017

1 reference

19 August 2017

PubMed publication ID

23934281

1 reference