Beta-cell apoptosis in type 2 diabetes: quantitative and functional consequences. (Q37221767)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18640587 AND SRC:MED&resulttype=core&format=json

11 January 2020

review article

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title

Beta-cell apoptosis in type 2 diabetes: quantitative and functional consequences (English)

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11 January 2020

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2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18640587 AND SRC:MED&resulttype=core&format=json

11 January 2020

author name string

R Lupi

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18640587 AND SRC:MED&resulttype=core&format=json

11 January 2020

publication date

1 February 2008

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11 January 2020

published in

Diabetes and Metabolism

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18640587 AND SRC:MED&resulttype=core&format=json

11 January 2020

volume

34 Suppl 2

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11 January 2020

page(s)

S56-64

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Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.

11 January 2020

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Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid

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Pancreatic islet dysfunction in type 2 diabetes: a rational target for incretin-based therapies

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beta-cell failure in diabetes and preservation by clinical treatment

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Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

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Glucotoxicity and beta-cell failure in type 2 diabetes mellitus

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Gliclazide protects human islet beta-cells from apoptosis induced by intermittent high glucose

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Increased O-glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic beta-cells

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Type 1 diabetes: new perspectives on disease pathogenesis and treatment

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Roles of cytokines in the pathogenesis and therapy of type 1 diabetes

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Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets

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7 January 2021

Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?

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Beta-cells in type 2 diabetes: a loss of function and mass

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Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets

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Endoplasmic reticulum stress and the development of diabetes: a review

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Protein folding in the endoplasmic reticulum and the unfolded protein response.

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The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

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7 January 2021

Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets

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Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function

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7 January 2021

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

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Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).

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Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes

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Role of nitric oxide in obesity-induced beta cell disease

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Glucolipotoxicity: fuel excess and beta-cell dysfunction.

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Co-localization of islet amyloid polypeptide and insulin in the B cell secretory granules of the human pancreatic islets

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Reduced amylin release is a characteristic of impaired glucose tolerance and type 2 diabetes in Japanese Americans

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Plasma islet amyloid polypeptide levels in obesity, impaired glucose tolerance and non-insulin-dependent diabetes mellitus

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Pancreatic amylin and calcitonin gene-related peptide cause resistance to insulin in skeletal muscle in vitro.

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Inhibitory effect of rat amylin on the insulin responses to glucose and arginine in the perfused rat pancreas

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Amylin and the amylin gene: structure, function and relationship to islet amyloid and to diabetes mellitus

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Human type 2 diabetes: morphological evidence for abnormal beta-cell function

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Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes

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7 January 2021

beta-cell deterioration - prospects for reversal or prevention

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7 January 2021

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

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7 January 2021

Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

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7 January 2021

Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells.

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7 January 2021

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

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7 January 2021

Change in pancreatic B-cell function (HOMA-B) varies in different populations with similar genetic backgrounds but different environments.

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7 January 2021

Sulfonylurea and glinide reduce insulin content, functional expression of KATP channels, and accelerate apoptotic β-cell death in the chronic phase

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7 January 2021

Sulfonylurea induced beta-cell apoptosis in cultured human islets

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7 January 2021

Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2 concentration

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7 January 2021

Effects of prolonged in vitro exposure to sulphonylureas on the function and survival of human islets

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7 January 2021

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

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7 January 2021

New sources of pancreatic beta-cells

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7 January 2021

Beta-cell mass plasticity in type 2 diabetes.

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The influence of amyloid deposits on the islet volume in maturity onset diabetes mellitus

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Morphometrical analysis on topographical difference in size distribution, number and volume of islets in the human pancreas

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Effects of hemipancreatectomy on insulin secretion and glucose tolerance in healthy humans

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Experimental reduction of B-cell mass: implications for the pathogenesis of diabetes

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Decrease in beta-cell mass leads to impaired pulsatile insulin secretion, reduced postprandial hepatic insulin clearance, and relative hyperglucagonemia in the minipig

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Mechanisms of impaired fasting glucose and glucose intolerance induced by an approximate 50% pancreatectomy

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Regulation of beta-cell mass by hormones and growth factors

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Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects*

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Plasma insulin responses to oral and venous glucose in various forms of diabetes mellitus

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7 January 2021

Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal

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The role of GLP-1 in the life and death of pancreatic beta cells.

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Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats

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Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas

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Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats.

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7 January 2021

Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis

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7 January 2021

Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5'-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway

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7 January 2021

Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets

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7 January 2021

Therapeutic approaches to preserve islet mass in type 2 diabetes

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7 January 2021

10.1016/S1262-3636(08)73396-2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18640587 AND SRC:MED&resulttype=core&format=json

11 January 2020

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