Huntington's disease: degradation of mutant huntingtin by autophagy (Q37220135)

19 August 2017

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title

Huntington's disease: degradation of mutant huntingtin by autophagy (English)

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19 August 2017

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Sovan Sarkar

1

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19 August 2017

David C Rubinsztein

series ordinal

2

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19 August 2017

language of work or name

English

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publication date

15 July 2008

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19 August 2017

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19 August 2017

volume

275

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19 August 2017

issue

17

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19 August 2017

page(s)

4263-4270

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Vacuolar import of proteins and organelles from the cytoplasm

19 August 2017

cites work

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

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21 January 2018

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Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells

21 January 2018

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21 January 2018

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Potential therapeutic applications of autophagy

21 January 2018

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Amino acid control of autophagic sequestration and protein degradation in isolated rat hepatocytes

21 January 2018

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Rapamycin alleviates toxicity of different aggregate-prone proteins

21 January 2018

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Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

21 January 2018

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

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α-Synuclein Is Degraded by Both Autophagy and the Proteasome

21 January 2018

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Lithium delays progression of amyotrophic lateral sclerosis

21 January 2018

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

21 January 2018

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

21 January 2018

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Lessons from animal models of Huntington's disease

21 January 2018

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Trinucleotide Repeat Disorders

21 January 2018

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Protein aggregation and neurodegenerative disease

21 January 2018

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Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic

21 January 2018

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Soluble androgen receptor oligomers underlie pathology in a mouse model of spinobulbar muscular atrophy

21 January 2018

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 January 2018

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Polyglutamine diseases: emerging concepts in pathogenesis and therapy

21 January 2018

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

21 January 2018

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A century-old debate on protein aggregation and neurodegeneration enters the clinic

21 January 2018

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The roles of intracellular protein-degradation pathways in neurodegeneration

21 January 2018

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Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

21 January 2018

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Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice

21 January 2018

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The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

21 January 2018

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Phosphorylation of ataxin-3 by glycogen synthase kinase 3beta at serine 256 regulates the aggregation of ataxin-3.

21 January 2018

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Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity

21 January 2018

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Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity

21 January 2018

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Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases.

21 January 2018

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Huntingtin localization in brains of normal and Huntington's disease patients

21 January 2018

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

21 January 2018

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Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration

21 January 2018

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Autophagosome-like vacuole formation in Huntington's disease lymphoblasts

21 January 2018

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Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1

21 January 2018

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Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

21 January 2018

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ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation.

21 January 2018

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Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin.

21 January 2018

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TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

21 January 2018

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21 January 2018

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Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation

21 January 2018

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Chronic lithium chloride treatment has variable effects on motor behaviour and survival of mice transgenic for the Huntington's disease mutation

21 January 2018

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21 January 2018

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GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

21 January 2018

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Role of trehalose phosphate synthase and trehalose during hypoxia: from flies to mammals

21 January 2018

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Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2008.06562.X

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2008.06562.X

Small molecule regulators of autophagy identified by an image-based high-throughput screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2008.06562.X

Unveiling the roles of autophagy in innate and adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2008.06562.X

10.1111/J.1742-4658.2008.06562.X

21 January 2018

Identifiers

DOI

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release_j4blt2fbj5enhg65fyr5gu6a5e

19 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/j4blt2fbj5enhg65fyr5gu6a5e

mapped directly with Wikidata item

24 November 2022

based on heuristic

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