ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice. (Q37200237)

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23 January 2020

title

ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice (English)

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23 January 2020

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23 January 2020

Lei Xi

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23 January 2020

author name string

Fadi N Salloum

2

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23 January 2020

Yuan J Rao

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23 January 2020

Rakesh C Kukreja

5

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publication date

13 March 2009

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American Journal of Physiology Heart and Circulatory Physiology

23 January 2020

published in

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volume

296

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issue

5

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page(s)

H1236-43

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IL-6 plays an obligatory role in late preconditioning via JAK-STAT signaling and upregulation of iNOS and COX-2.

23 January 2020

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Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality

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Serine phosphorylation of STATs

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Role of the protein kinase C-epsilon-Raf-1-MEK-1/2-p44/42 MAPK signaling cascade in the activation of signal transducers and activators of transcription 1 and 3 and induction of cyclooxygenase-2 after ischemic preconditioning

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Protein kinase G-dependent cardioprotective mechanism of phosphodiesterase-5 inhibition involves phosphorylation of ERK and GSK3beta

14 September 2017

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Sildenafil induces delayed preconditioning through inducible nitric oxide synthase-dependent pathway in mouse heart.

26 June 2018

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Sildenafil (Viagra) evokes retinal arteriolar dilation: dual pathways via NOS activation and phosphodiesterase inhibition

26 June 2018

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Sildenafil (Viagra) attenuates ischemic cardiomyopathy and improves left ventricular function in mice

3 September 2018

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Essential role of mitochondrial Ca2 -activated and ATP-sensitive K channels in sildenafil-induced late cardioprotection.

3 September 2018

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Inhibition of glycogen synthase kinase 3beta during heart failure is protective

3 September 2018

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Potentiation of a survival signal in the ischemic heart by resveratrol through p38 mitogen-activated protein kinase/mitogen- and stress-activated protein kinase 1/cAMP response element-binding protein signaling

3 September 2018

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Localizing extracellular signal-regulated kinase (ERK) in pharmacological preconditioning's trigger pathway

3 September 2018

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Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling.

3 September 2018

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Protein kinase C plays an essential role in sildenafil-induced cardioprotection in rabbits

3 September 2018

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NECA and bradykinin at reperfusion reduce infarction in rabbit hearts by signaling through PI3K, ERK, and NO.

3 September 2018

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Exogenous nitric oxide generates ROS and induces cardioprotection: involvement of PKG, mitochondrial KATP channels, and ERK.

3 September 2018

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Sildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial K(ATP) channels in rabbits

3 September 2018

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Differential activation of extracellular signal regulated kinase isoforms in preconditioning and opioid-induced cardioprotection.

3 September 2018

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Essential role of inducible nitric oxide synthase in monophosphoryl lipid A-induced late cardioprotection: evidence from pharmacological inhibition and gene knockout mice

3 September 2018

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12 December 2020

Inhibition of extracellular signal-regulated kinase enhances Ischemia/Reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerates reperfusion injury in isolated perfused heart

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12 December 2020

Inhibition of the ER-kinase cascade by PD98059 and UO126 counteracts ischemic preconditioning in pig myocardium

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Role of ERK1/2 in the anti-apoptotic and cardioprotective effects of nitric oxide after myocardial ischemia and reperfusion

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Cross talk between nitric oxide and ERK1/2 signaling pathway in the spinal cord mediates naloxone-precipitated withdrawal in morphine-dependent rats

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Ambient pressure upregulates nitric oxide synthase in a phosphorylated-extracellular regulated kinase- and protein kinase C-dependent manner

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10.1152/AJPHEART.00100.2009

Identifiers

DOI

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23 January 2020

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23 January 2020

PubMed publication ID

19286961

1 reference