Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes. (Q37194921)

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8 March 2020

title

Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes (English)

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8 March 2020

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8 March 2020

Sergei B Koralov

3

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8 March 2020

Thorsten Buch

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8 March 2020

Klaus Rajewsky

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8 March 2020

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Harald von Boehmer

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8 March 2020

author name string

Hye-Jung Kim

2

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8 March 2020

Dvora Ghitza

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8 March 2020

Harvey Cantor

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8 March 2020

language of work or name

English

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publication date

26 August 2013

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Journal of Experimental Medicine

8 March 2020

published in

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volume

210

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8 March 2020

issue

10

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8 March 2020

page(s)

1911-1918

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Helios marks strongly autoreactive CD4 T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB.

8 March 2020

cites work

1 reference

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CD8 T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice

6 September 2017

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Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla

6 September 2017

1 reference

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Lineage diversion of T cell receptor transgenic thymocytes revealed by lineage fate mapping.

6 September 2017

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The timing of TCR alpha expression critically influences T cell development and selection

6 September 2017

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Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat cells

6 September 2017

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Receptor revision in T cells: an open question?

6 September 2017

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Antigen receptor selection by editing or downregulation of V(D)J recombination.

6 September 2017

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Premature expression of T cell receptor (TCR)alphabeta suppresses TCRgammadelta gene rearrangement but permits development of gammadelta lineage T cells

6 September 2017

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RAG reexpression and DNA recombination at T cell receptor loci in peripheral CD4 T cells

6 September 2017

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Rapid deletion of rearranged T cell antigen receptor (TCR) Valpha-Jalpha segment by secondary rearrangement in the thymus: role of continuous rearrangement of TCR alpha chain gene and positive selection in the T cell repertoire formation.

6 September 2017

1 reference

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Receptor editing in a transgenic mouse model: site, efficiency, and role in B cell tolerance and antibody diversification

6 September 2017

1 reference

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Targeted oncogene activation by site-specific recombination in transgenic mice

6 September 2017

1 reference

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Faithful activation of an extra-bright red fluorescent protein in "knock-in" Cre-reporter mice ideally suited for lineage tracing studies.

6 September 2017

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A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration.

14 September 2017

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The transcriptional landscape of αβ T cell differentiation

14 September 2017

1 reference

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Cyclin A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair

28 September 2017

1 reference

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Inhibition of follicular T-helper cells by CD8( ) regulatory T cells is essential for self tolerance.

28 September 2017

1 reference

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The alpha beta T cell receptor can replace the gamma delta receptor in the development of gamma delta lineage cells.

26 June 2018

1 reference

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T cell receptor beta chain dimers on immature thymocytes from normal mice

26 June 2018

1 reference

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In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes

26 June 2018

1 reference

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Two signals are required for negative selection of CD4 CD8 thymocytes

26 June 2018

1 reference

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Failure of HY-Specific Thymocytes to Escape Negative Selection by Receptor Editing

3 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1084/JEM.20130876

MHC-restricted T cell receptor signaling is required for αβ TCR replacement of the pre T cell receptor

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1084/JEM.20130876

Transcriptional analysis of clonal deletion in vivo

21 January 2018

1 reference

12 December 2020

Receptor editing in developing T cells

1 reference

12 December 2020

Using an in vivo phagemid system to identify non-compatible loxP sequences

1 reference

12 December 2020

Central tolerance to self-antigen expressed by cortical epithelial cells

1 reference

12 December 2020

A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle

1 reference

12 December 2020

Identifiers

DOI

10.1084/JEM.20130876

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23980099 AND SRC:MED&resulttype=core&format=json

8 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23980099 AND SRC:MED&resulttype=core&format=json

8 March 2020

PubMed publication ID

23980099

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23980099 AND SRC:MED&resulttype=core&format=json