NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene. (Q37182024)

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scientific article published on 12 July 2016

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English	NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene.	scientific article published on 12 July 2016

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18 March 2020

NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene (English)

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18 March 2020

Marie Stiborová

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18 March 2020

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18 March 2020

Michaela Moserová

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18 March 2020

David H. Phillips

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18 March 2020

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Eva Frei

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18 March 2020

Heinz H Schmeiser

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18 March 2020

Klaus Kopka

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18 March 2020

Volker M Arlt

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18 March 2020

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20 July 2016

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18 March 2020

Chemical Research in Toxicology

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18 March 2020

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18 March 2020

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18 March 2020

1325-1334

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18 March 2020

Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1.

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The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53( / ), Trp53( /-) and Trp53(-/-) mice

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Identification and characterization of a novel benzo[a]pyrene-derived DNA adduct

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NADPH- and NADH-dependent metabolism of and DNA adduct formation by benzo[a]pyrene catalyzed with rat hepatic microsomes and cytochrome P450 1A1.

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Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: Detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and 32P-postlabelling.

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1 reference

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Improved isolation of rat microsomal cytochrome b5 reductase

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochromes P450 reconstituted with NADPH: P450 reductase mimic the activating and detoxicating metabolism of the anticancer drug ellipticine in microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27404282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of cytochrome b5 in hydroxylation by a reconstituted cytochrome P-450-containing system

1 reference

https://pubmed.ncbi.nlm.nih.gov/27404282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydroperoxide-dependent oxygenation of trans-7,8-dihydroxy-7,8-dihydro benzo[a]pyrene by ram seminal vesicle microsomes. Source of the oxygen

1 reference

https://pubmed.ncbi.nlm.nih.gov/27404282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/27404282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidation of benzo[a]pyrene by recombinant human cytochrome P450 enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27404282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome b5 shifts oxidation of the anticancer drug ellipticine by cytochromes P450 1A1 and 1A2 from its detoxication to activation, thereby modulating its pharmacological efficacy

1 reference

https://pubmed.ncbi.nlm.nih.gov/27404282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/ACS.CHEMRESTOX.6B00143

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27404282 AND SRC:MED&resulttype=core&format=json

18 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27404282 AND SRC:MED&resulttype=core&format=json

18 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27404282 AND SRC:MED&resulttype=core&format=json

18 March 2020

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