Regulatory light chain mutations associated with cardiomyopathy affect myosin mechanics and kinetics (Q37175862)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18929571 AND SRC:MED&resulttype=core&format=json

24 December 2019

title

Regulatory light chain mutations associated with cardiomyopathy affect myosin mechanics and kinetics (English)

1 reference

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24 December 2019

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1

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24 December 2019

author name string

James D Watt

2

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24 December 2019

Michelle Jones

3

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24 December 2019

Katarzyna Kazmierczak

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18929571 AND SRC:MED&resulttype=core&format=json

24 December 2019

Danuta Szczesna-Cordary

5

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24 December 2019

Jeffrey R Moore

6

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24 December 2019

publication date

27 September 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18929571 AND SRC:MED&resulttype=core&format=json

Journal of Molecular and Cellular Cardiology

24 December 2019

published in

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24 December 2019

volume

46

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24 December 2019

issue

1

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24 December 2019

page(s)

108-115

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18929571 AND SRC:MED&resulttype=core&format=json

Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone

24 December 2019

cites work

1 reference

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6 September 2017

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6 September 2017

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Myoinformatics report: myosin regulatory light chain paralogs in the human genome

6 September 2017

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Sarcomeric proteins and familial hypertrophic cardiomyopathy: linking mutations in structural proteins to complex cardiovascular phenotypes

6 September 2017

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Genetic causes of human heart failure

6 September 2017

1 reference

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Adenosine diphosphate and strain sensitivity in myosin motors.

6 September 2017

1 reference

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The tail of myosin reduces actin filament velocity in the in vitro motility assay

6 September 2017

1 reference

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A point mutation in the regulatory light chain reduces the step size of skeletal muscle myosin

6 September 2017

1 reference

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Energy metabolism in heart failure

6 September 2017

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Activation of the Calcium-Regulated Thin Filament by Myosin Strong Binding

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2675789

Regulatory light chains of striated muscle myosin. Structure, function and malfunction

6 September 2017

1 reference

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Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy

6 September 2017

1 reference

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Systematic analysis of the regulatory and essential myosin light chain genes: genetic variants and mutations in hypertrophic cardiomyopathy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2675789

The young competitive athlete with cardiovascular abnormalities: causes of sudden death, detection by preparticipation screening, and standards for disqualification

6 September 2017

1 reference

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Myosin light chain mutations in familial hypertrophic cardiomyopathy: phenotypic presentation and frequency in Danish and South African populations

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2675789

Myosin V exhibits a high duty cycle and large unitary displacement

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2675789

The yeast class V myosins, Myo2p and Myo4p, are nonprocessive actin-based motors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2675789

R403Q and L908V mutant beta-cardiac myosin from patients with familial hypertrophic cardiomyopathy exhibit enhanced mechanical performance at the single molecule level

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2675789

Familial hypertrophic cardiomyopathy mutations in the regulatory light chains of myosin affect their structure, Ca2 binding, and phosphorylation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2675789

Single-molecule mechanics of R403Q cardiac myosin isolated from the mouse model of familial hypertrophic cardiomyopathy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2675789

Tropomyosin directly modulates actomyosin mechanical performance at the level of a single actin filament

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2675789

Diastolic dysfunction and altered energetics in the alphaMHC403/ mouse model of familial hypertrophic cardiomyopathy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2675789

Identification of two novel mutations in the ventricular regulatory myosin light chain gene (MYL2) associated with familial and classical forms of hypertrophic cardiomyopathy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2675789

Altered kinetics of contraction in skeletal muscle fibers containing a mutant myosin regulatory light chain with reduced divalent cation binding

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2675789

Mutations in either the essential or regulatory light chains of myosin are associated with a rare myopathy in human heart and skeletal muscle

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2675789

Three-dimensional structure of myosin subfragment-1: a molecular motor

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2675789

Fluorescent actin filaments move on myosin fixed to a glass surface

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2675789

Effect of phosphorylation of smooth muscle myosin on actin activation and Ca2 regulation

6 September 2017

1 reference

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Structure-function studies on Acanthamoeba myosins IA, IB, and II.

6 September 2017

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A model for the coregulation of smooth muscle actomyosin by caldesmon, calponin, tropomyosin, and the myosin regulatory light chain.

14 September 2017

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Ca-Linked Phosphorylation of a Light Chain of Vertebrate Smooth-Muscle Myosin

14 September 2017

1 reference

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Myosin light chain phosphorylation in vertebrate striated muscle: regulation and function

14 September 2017

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Mutations in human cardiac troponin I that are associated with restrictive cardiomyopathy affect basal ATPase activity and the calcium sensitivity of force development

28 September 2017

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Influence of temperature upon contractile activation and isometric force production in mechanically skinned muscle fibers of the frog

27 June 2018

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A phosphorylated light-chain component of myosin from skeletal muscle

27 June 2018

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Troponin-tropomyosin complex. Column chromatographic separation and activity of the three, active troponin components with and without tropomyosin present.

27 June 2018

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Site-directed mutagenesis of the regulatory light-chain Ca2 /Mg2 binding site and its role in hybrid myosins.

27 June 2018

1 reference

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Myosin step size. Estimation from slow sliding movement of actin over low densities of heavy meromyosin

27 June 2018

1 reference

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Novel sensors of the regulatory switch on the regulatory light chain of smooth muscle Myosin

27 June 2018

1 reference

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Human homozygous R403W mutant cardiac myosin presents disproportionate enhancement of mechanical and enzymatic properties.

3 September 2018

1 reference

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Familial Hypertrophic Cardiomyopathy-linked Alterations in Ca2 Binding of Human Cardiac Myosin Regulatory Light Chain Affect Cardiac Muscle Contraction

3 September 2018

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A simple method for measuring the relative force exerted by myosin on actin filaments in the in vitro motility assay: evidence that tropomyosin and troponin increase force in single thin filaments

3 September 2018

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The molecular and cellular pathophysiology of heart failure.

3 September 2018

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Smooth and skeletal muscle myosin both exhibit low duty cycles at zero load in vitro.

3 September 2018

1 reference

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Preparation of troponin and its subunits

3 September 2018

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Myosin regulatory light chain E22K mutation results in decreased cardiac intracellular calcium and force transients

3 September 2018

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Prolonged Ca2 and force transients in myosin RLC transgenic mouse fibers expressing malignant and benign FHC mutations

7 January 2021

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Altered regulation of cardiac muscle contraction by troponin T mutations that cause familial hypertrophic cardiomyopathy

7 January 2021

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An accelerated state of myosin-based actin motility

7 January 2021

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The Determination of Enzyme Dissociation Constants

7 January 2021

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Structural and functional responses of mammalian thick filaments to alterations in myosin regulatory light chains

7 January 2021

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High energy phosphate of the myocardium: concentration versus free energy change

7 January 2021

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18929571

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Is the lever arm of myosin a molecular elastic element?

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18929571

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.YJMCC.2008.09.126

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18929571 AND SRC:MED&resulttype=core&format=json

24 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18929571 AND SRC:MED&resulttype=core&format=json

24 December 2019

PubMed publication ID

18929571

1 reference