Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene (Q37173658)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19416908 AND SRC:MED&resulttype=core&format=json

27 January 2020

title

Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene (English)

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27 January 2020

8

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Jeffrey A Knauf

13

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5

Pat Zanzonico

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27 January 2020

author name string

Xu Chen

1

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27 January 2020

Norisato Mitsutake

2

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27 January 2020

Krista LaPerle

3

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27 January 2020

Nagako Akeno

4

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27 January 2020

Valerie A Longo

6

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27 January 2020

Shin Mitsutake

7

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27 January 2020

Hartmut Geiger

9

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27 January 2020

Eugenio Santos

10

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27 January 2020

Hans G Wendel

11

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27 January 2020

Aime Franco

12

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27 January 2020

James A Fagin

14

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language of work or name

English

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publication date

29 April 2009

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Proceedings of the National Academy of Sciences of the United States of America

27 January 2020

published in

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27 January 2020

volume

106

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issue

19

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27 January 2020

page(s)

7979-7984

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Kras regulatory elements and exon 4A determine mutation specificity in lung cancer

27 January 2020

cites work

1 reference

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A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition

6 September 2017

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The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders

6 September 2017

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Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

6 September 2017

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Hyperactive Ras in developmental disorders and cancer

6 September 2017

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Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis

6 September 2017

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Hyperactivation of Ha-ras oncogene, but not Ink4a/Arf deficiency, triggers bladder tumorigenesis

6 September 2017

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Genotype-phenotype correlation in Costello syndrome: HRAS mutation analysis in 43 cases.

6 September 2017

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Germline mutations in HRAS proto-oncogene cause Costello syndrome

6 September 2017

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

6 September 2017

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Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder

6 September 2017

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While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable.

6 September 2017

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Costello syndrome: an overview

6 September 2017

1 reference

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Direct visualization of Ras proteins in spatially distinct cell surface microdomains

6 September 2017

1 reference

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Further delineation of cardiac abnormalities in Costello syndrome

6 September 2017

1 reference

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Five additional Costello syndrome patients with rhabdomyosarcoma: proposal for a tumor screening protocol

6 September 2017

1 reference

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Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development

6 September 2017

1 reference

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K-ras is an essential gene in the mouse with partial functional overlap with N-ras

6 September 2017

1 reference

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

6 September 2017

1 reference

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Multiple tumor types appear in a transgenic mouse with the ras oncogene.

6 September 2017

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The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle

6 September 2017

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Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice

6 September 2017

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Oncogenic RAS induces accelerated transition through G2/M and promotes defects in the G2 DNA damage and mitotic spindle checkpoints

14 September 2017

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Regulation of endothelial cell differentiation and transformation by H-Ras

14 September 2017

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Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context

14 September 2017

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Plasmid-based transgenic mouse model for studying in vivo mutations

14 September 2017

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Biochemical characterization of polypeptides encoded by mutated human Ha-ras1 genes

14 September 2017

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Wildtype Kras2 can inhibit lung carcinogenesis in mice

14 September 2017

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P53-dependent effects of RAS oncogene on chromosome stability and cell cycle checkpoints

28 September 2017

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MAPK mediates RAS-induced chromosome instability

28 September 2017

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Mitotic and post mitotic consequences of genomic instability induced by oncogenic Ha-ras

27 June 2018

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Predisposition to neoplastic transformation caused by gene replacement of H-ras1.

27 June 2018

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Increased methotrexate resistance and dhfr gene amplification as a consequence of induced Ha-ras expression in NIH 3T3 cells

27 June 2018

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Site-specific mutation of the human c-Ha-ras transgene induced by dimethylbenzanthracene causes tissue-specific tumors in mice.

27 June 2018

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Biological properties of human c-Ha-ras1 genes mutated at codon 12.

27 June 2018

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Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis.

27 June 2018

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HRAS mutations in Costello syndrome: detection of constitutional activating mutations in codon 12 and 13 and loss of wild-type allele in malignancy.

3 September 2018

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HRAS mutation analysis in Costello syndrome: genotype and phenotype correlation.

3 September 2018

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Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

3 September 2018

1 reference

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The RAS oncogene induces genomic instability in thyroid PCCL3 cells via the MAPK pathway

3 September 2018

1 reference

12 December 2020

The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene

1 reference

12 December 2020

Mutagenic potential of temozolomide in bone marrow cells in vivo

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12 December 2020

Reactive oxygen species, DNA damage, and error-prone repair: a model for genomic instability with progression in myeloid leukemia?

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0900343106

1 reference

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27 January 2020

0 references

1 reference

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27 January 2020

PubMed publication ID

19416908

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19416908 AND SRC:MED&resulttype=core&format=json