Towards small-molecule CXCR3 ligands with clinical potential. (Q37149335)

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6 January 2020

review article

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title

Towards small-molecule CXCR3 ligands with clinical potential (English)

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6 January 2020

2

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6 January 2020

author name string

Maikel Wijtmans

1

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6 January 2020

Rob Leurs

3

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6 January 2020

Iwan J P de Esch

4

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6 January 2020

Martine J Smit

5

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6 January 2020

language of work or name

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1 June 2008

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6 January 2020

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6 January 2020

volume

3

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issue

6

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6 January 2020

page(s)

861-872

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Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice

6 January 2020

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Mutating the four extracellular cysteines in the chemokine receptor CCR6 reveals their differing roles in receptor trafficking, ligand binding, and signaling

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Intracellular domains of CXCR3 that mediate CXCL9, CXCL10, and CXCL11 function

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The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions

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Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s

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Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3

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Human B cell-attracting chemokine 1 (BCA-1; CXCL13) is an agonist for the human CXCR3 receptor

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7 January 2021

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

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7 January 2021

CXCR3-mediated chemotaxis of human T cells is regulated by a Gi- and phospholipase C-dependent pathway and not via activation of MEK/p44/p42 MAPK nor Akt/PI-3 kinase

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7 January 2021

CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11

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7 January 2021

The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP10, are natural antagonists for CCR3

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7 January 2021

Human interferon-inducible 10-kDa protein and human interferon-inducible T cell alpha chemoattractant are allotopic ligands for human CXCR3: differential binding to receptor states.

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Extension of recombinant human RANTES by the retention of the initiating methionine produces a potent antagonist.

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Antagonist of interferon-inducible protein 10/CXCL10 ameliorates the progression of autoimmune sialadenitis in MRL/lpr mice

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7 January 2021

Processing of natural and recombinant CXCR3-targeting chemokines and implications for biological activity

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7 January 2021

Amino-terminal truncation of CXCR3 agonists impairs receptor signaling and lymphocyte chemotaxis, while preserving antiangiogenic properties

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Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients

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Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Genetic deletion of chemokine receptor CXCR3 or antibody blockade of its ligand IP-10 modulates posttransplantation graft-site lymphocytic infiltrates and prolongs functional graft survival in pancreatic islet allograft recipients

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7 January 2021

Blockade of interferon-gamma-inducible protein-10 attenuates chronic experimental colitis by blocking cellular trafficking and protecting intestinal epithelial cells

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7 January 2021

Role of CXCR3 and CCR5 in allograft rejection

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7 January 2021

Donor-derived IP-10 initiates development of acute allograft rejection

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7 January 2021

Donor T cell activation initiates small bowel allograft rejection through an IFN-gamma-inducible protein-10-dependent mechanism

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7 January 2021

Blockade of chemokine receptor CXCR3 inhibits T cell recruitment to inflamed joints and decreases the severity of adjuvant arthritis

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7 January 2021

Proteolytic processing of SDF-1alpha reveals a change in receptor specificity mediating HIV-associated neurodegeneration

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7 January 2021

The unique target specificity of a nonpeptide chemokine receptor antagonist: selective blockade of two Th1 chemokine receptors CCR5 and CXCR3.

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7 January 2021

A novel small-molecule compound targeting CCR5 and CXCR3 prevents acute and chronic allograft rejection

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7 January 2021

A novel CCR5/CXCR3 antagonist protects intestinal ischemia/reperfusion injury.

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7 January 2021

The simultaneous blockade of chemokine receptors CCR2, CCR5 and CXCR3 by a non-peptide chemokine receptor antagonist protects mice from dextran sodium sulfate-mediated colitis

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7 January 2021

Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3.

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7 January 2021

Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3

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7 January 2021

Synthesis and structure-activity relationship of 3-phenyl-3H-quinazolin-4-one derivatives as CXCR3 chemokine receptor antagonists

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7 January 2021

Pharmacological characterization of CXC chemokine receptor 3 ligands and a small molecule antagonist.

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7 January 2021

Analysis of the pharmacokinetic/pharmacodynamic relationship of a small molecule CXCR3 antagonist, NBI-74330, using a murine CXCR3 internalization assay

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7 January 2021

CXCR3 antagonist NBI-74330 attenuates atherosclerotic plaque formation in LDL receptor-deficient mice

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7 January 2021

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Optimization of the heterocyclic core of the quinazolinone-derived CXCR3 antagonists

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7 January 2021

Identification and structure-activity relationships of 1-aryl-3-piperidin-4-yl-urea derivatives as CXCR3 receptor antagonists

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7 January 2021

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7 January 2021

Development of CXCR3 antagonists. Part 3: Tropenyl and homotropenyl-piperidine urea derivatives

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7 January 2021

Development of CXCR3 antagonists. Part 4: discovery of 2-amino-(4-tropinyl)quinolines

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7 January 2021

Complex synthetic chemical libraries indexed with molecular tags

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7 January 2021

Identification and initial evaluation of 4-N-aryl-[1,4]diazepane ureas as potent CXCR3 antagonists

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7 January 2021

Identification of CXCR3 receptor agonists in combinatorial small-molecule libraries

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7 January 2021

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7 January 2021

An apparent paradox: chemokine receptor agonists can be used for anti-inflammatory therapy.

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7 January 2021

IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo

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7 January 2021

The CXCR3 targeting chemokine CXCL11 has potent antitumor activity in vivo involving attraction of CD8 T lymphocytes but not inhibition of angiogenesis

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7 January 2021

Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8.

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7 January 2021

Pyrrolidinohydroquinazolines--a novel class of CCR3 modulators

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7 January 2021

A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5

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7 January 2021

Human CXCR2 (hCXCR2) takes over functionalities of its murine homolog in hCXCR2 knockin mice

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7 January 2021

Species selectivity of small-molecular antagonists for the CCR5 chemokine receptor

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7 January 2021

Crystal structure of rhodopsin: A G protein-coupled receptor

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7 January 2021

Identifiers

DOI

10.1002/CMDC.200700365

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18442035 AND SRC:MED&resulttype=core&format=json

6 January 2020

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