NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K efflux and Ca2 influx. (Q37139393)

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scientific article published on 11 May 2016

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English	NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K efflux and Ca2 influx.	scientific article published on 11 May 2016

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4 April 2020

NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K efflux and Ca2 influx (English)

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inflammasome complex

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George R. Dubyak

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Michael A Katsnelson

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Kristen M Lozada-Soto

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Hana M Russo

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Barbara A Miller

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11 May 2016

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American Journal of Physiology - Cell Physiology

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1

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C83-C100

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4 April 2020

Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling

1 reference

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Negative regulation of the inflammasome: keeping inflammation under control.

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Bacterial recognition pathways that lead to inflammasome activation

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Regulation of inflammasome activation

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Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents

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14 September 2017

K efflux agonists induce NLRP3 inflammasome activation independently of Ca2 signaling

1 reference

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14 September 2017

IKKα negatively regulates ASC-dependent inflammasome activation

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The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation.

1 reference

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A proteolytic cascade controls lysosome rupture and necrotic cell death mediated by lysosome-destabilizing adjuvants.

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Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation

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Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes

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Lysosomes integrate metabolic-inflammatory cross-talk in primary macrophage inflammasome activation

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TRPM2 channels protect against cardiac ischemia-reperfusion injury: role of mitochondria

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Biochemical and structural aspects of the ATP-binding domain in inflammasome-forming human NLRP proteins

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14 September 2017

Cytosolic flagellin-induced lysosomal pathway regulates inflammasome-dependent and -independent macrophage responses

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CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

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14 September 2017

K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4967136

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Role of lysosome rupture in controlling Nlrp3 signaling and necrotic cell death

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4967136

14 September 2017

TRPM2 links oxidative stress to NLRP3 inflammasome activation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4967136

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Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants

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Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome

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14 September 2017

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

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The TRPM2 ion channel, an oxidative stress and metabolic sensor regulating innate immunity and inflammation

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14 September 2017

Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation

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Uric acid as a danger signal in gout and its comorbidities

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14 September 2017

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

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14 September 2017

Calcium-mediated cell death during myocardial reperfusion

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Non-canonical inflammasome activation targets caspase-11

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Macrophages in the Pathogenesis of Atherosclerosis

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Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

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International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family

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Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation

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14 September 2017

Technical advance: Caspase-1 activation and IL-1β release correlate with the degree of lysosome damage, as illustrated by a novel imaging method to quantify phagolysosome damage.

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14 September 2017

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

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14 September 2017

The inflammasomes

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14 September 2017

Critical functions of priming and lysosomal damage for NLRP3 activation

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Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

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Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling

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Gout-associated uric acid crystals activate the NALP3 inflammasome

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27 June 2018

Dousing fire with gasoline: interplay between lysosome damage and the NLRP3 inflammasome. Focus on "NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K efflux and Ca

1 reference

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3 September 2018

TRPM2 mediates ischemic kidney injury and oxidant stress through RAC1.

1 reference

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3 September 2018

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1 reference

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3 September 2018

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1 reference

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The Inflammasome in Atherosclerosis and Type 2 Diabetes

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1152/AJPCELL.00298.2015

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PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27170638 AND SRC:MED&resulttype=core&format=json

4 April 2020

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