Intrinsic structural disorder in adenovirus E1A: a viral molecular hub linking multiple diverse processes. (Q37127084)

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5 January 2020

review article

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title

Intrinsic structural disorder in adenovirus E1A: a viral molecular hub linking multiple diverse processes (English)

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5 January 2020

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4

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5 January 2020

author name string

Peter Pelka

1

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5 January 2020

Jailal N G Ablack

2

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5 January 2020

Gregory J Fonseca

3

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5 January 2020

Joe S Mymryk

5

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5 January 2020

language of work or name

English

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publication date

2 April 2008

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5 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18385237 AND SRC:MED&resulttype=core&format=json

5 January 2020

volume

82

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5 January 2020

issue

15

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5 January 2020

page(s)

7252-7263

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Adenovirus e1a proteins and transformation (review)

5 January 2020

cites work

1 reference

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Transcriptional regulation by C-terminal binding proteins

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14 September 2017

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14 September 2017

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Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus

14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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E1A and a nuclear receptor corepressor splice variant (N-CoRI) are thyroid hormone receptor coactivators that bind in the corepressor mode

14 September 2017

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Viral oncoproteins E1A and E7 and cellular LxCxE proteins repress SUMO modification of the retinoblastoma tumor suppressor

14 September 2017

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Intrinsically unstructured proteins and their functions

14 September 2017

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Natively disordered proteins: functions and predictions

14 September 2017

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Evidence for dynamically organized modularity in the yeast protein-protein interaction network

14 September 2017

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14 September 2017

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14 September 2017

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A novel E1A-E1B mutant adenovirus induces glioma regression in vivo

14 September 2017

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E1A and E1B proteins inhibit inflammation induced by adenovirus

14 September 2017

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EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer

14 September 2017

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CtBP/BARS: a dual-function protein involved in transcription co-repression and Golgi membrane fission

14 September 2017

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The polycomb protein Pc2 is a SUMO E3

14 September 2017

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E1A deregulates the centrosome cycle in a Ran GTPase-dependent manner.

14 September 2017

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14 September 2017

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14 September 2017

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Three regions of the pRB pocket domain affect its inactivation by human papillomavirus E7 proteins

14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha

14 September 2017

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Adenovirus E1A N-terminal amino acid sequence requirements for repression of transcription in vitro and in vivo correlate with those required for E1A interference with TBP-TATA complex formation

14 September 2017

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Adenovirus E1A: remodelling the host cell, a life or death experience

14 September 2017

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The conserved Mynd domain of BS69 binds cellular and oncoviral proteins through a common PXLXP motif

14 September 2017

1 reference

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Technology evaluation: tgDCC-E1A, targeted genetics/MD Anderson

14 September 2017

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The p400 complex is an essential E1A transformation target

14 September 2017

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Retinoblastoma protein partners

14 September 2017

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Binding of PKA-RIIalpha to the Adenovirus E1A12S oncoprotein correlates with its nuclear translocation and an increase in PKA-dependent promoter activity

14 September 2017

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Lethality and centrality in protein networks

14 September 2017

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Interaction of the E1A oncoprotein with Yak1p, a novel regulator of yeast pseudohyphal differentiation, and related mammalian kinases

14 September 2017

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14 September 2017

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Regulation of the 26S proteasome by adenovirus E1A

14 September 2017

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14 September 2017

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The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors

14 September 2017

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14 September 2017

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Characterization of an E1A-CBP interaction defines a novel transcriptional adapter motif (TRAM) in CBP/p300

14 September 2017

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Adenovirus early region 1A protein binds to mammalian SUG1-a regulatory component of the proteasome

14 September 2017

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14 September 2017

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E1A directly binds and regulates the P/CAF acetyltransferase

14 September 2017

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AR1 is an integral part of the adenovirus type 2 E1A-CR3 transactivation domain.

14 September 2017

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Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7

14 September 2017

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mUBC9, a novel adenovirus E1A-interacting protein that complements a yeast cell cycle defect

14 September 2017

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Repression of a matrix metalloprotease gene by E1A correlates with its ability to bind to cell type-specific transcription factor AP-2.

14 September 2017

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Induction of susceptibility to tumor necrosis factor by E1A is dependent on binding to either p300 or p105-Rb and induction of DNA synthesis

14 September 2017

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A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis

14 September 2017

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Identification of distinct roles for separate E1A domains in disruption of E2F complexes

14 September 2017

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E1A-mediated inhibition of myogenesis correlates with a direct physical interaction of E1A12S and basic helix-loop-helix proteins

14 September 2017

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Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation

14 September 2017

1 reference

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Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes

14 September 2017

1 reference

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The zinc finger region of the adenovirus E1A transactivating domain complexes with the TATA box binding protein

14 September 2017

1 reference

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BS69, a novel adenovirus E1A-associated protein that inhibits E1A transactivation

14 September 2017

1 reference

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Subregions of the adenovirus E1A transactivation domain target multiple components of the TFIID complex

14 September 2017

1 reference

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Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor

14 September 2017

1 reference

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Efficient nuclear localization and immortalizing ability, two functions dependent on the adenovirus type 5 (Ad5) E1A second exon, are necessary for cotransformation with Ad5 E1B but not with T24ras

14 September 2017

1 reference

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E1A promotes association between p300 and pRB in multimeric complexes required for normal biological activity

14 September 2017

1 reference

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Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation

14 September 2017

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Transcription factor TFIID is a direct functional target of the adenovirus E1A transcription-repression domain.

14 September 2017

1 reference

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The viral oncoproteins Ad5 E1A, HPV16 E7 and SV40 TAg bind a common region of the TBP-associated factor-110.

14 September 2017

1 reference

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Functions of purified E1A protein microinjected into mammalian cells

14 September 2017

1 reference

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E1a regions of the human adenoviruses and of the highly oncogenic simian adenovirus 7 are closely related

14 September 2017

1 reference

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Identification of separate domains in the adenovirus E1A gene for immortalization activity and the activation of virus early genes

14 September 2017

1 reference

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Mapping of cellular protein-binding sites on the products of early-region 1A of human adenovirus type 5.

14 September 2017

1 reference

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The 289-amino acid E1A protein of adenovirus binds zinc in a region that is important for trans-activation

14 September 2017

1 reference

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Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

14 September 2017

1 reference

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Adenovirus E1a ras cooperation activity is separate from its positive and negative transcription regulatory functions

14 September 2017

1 reference

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Prediction of similar transforming regions in simian virus 40 large T, adenovirus E1A, and myc oncoproteins

14 September 2017

1 reference

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Two regions of the adenovirus early region 1A proteins are required for transformation.

14 September 2017

1 reference

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A novel adenovirus-2 E1A mRNA encoding a protein with transcription activation properties

14 September 2017

1 reference

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Differential splicing yields novel adenovirus 5 E1A mRNAs that encode 30 kd and 35 kd proteins

14 September 2017

1 reference

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Genetic dissection of the transactivating domain of the E1a 289R protein of adenovirus type 2

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Transcription activation by the adenovirus E1a protein

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Analysis of E1A-mediated growth regulation functions: binding of the 300-kilodalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

A specific member of the ATF transcription factor family can mediate transcription activation by the adenovirus E1a protein

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Transcriptional and Transforming Activities of the Adenovirus E1A Proteins

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Conversion of the E1A Cys4 zinc finger to a nonfunctional His2,Cys2 zinc finger by a single point mutation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

trans-dominant mutants of E1A provide genetic evidence that the zinc finger of the trans-activating domain binds a transcription factor

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Induction of AP-1 DNA-binding activity and c-fos mRNA by the adenovirus 243R E1A protein and cyclic AMP requires domains necessary for transformation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Regulation of the Primary Expression of the Early Adenovirus Transcription Units

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

An adenovirus type 5 early gene function regulates expression of other early viral genes

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

BS69 is involved in cellular senescence through the p53-p21Cip1 pathway.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Increased expression of Dyrk1a in HPV16 immortalized keratinocytes enable evasion of apoptosis.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Recruitment of CBP/p300, TATA-binding protein, and S8 to distinct regions at the N terminus of adenovirus E1A.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Comprehensive sequence analysis of the E1A proteins of human and simian adenoviruses.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

A multicenter Phase I gene therapy clinical trial involving intraperitoneal administration of E1A-lipid complex in patients with recurrent epithelial ovarian cancer overexpressing HER-2/neu oncogene.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

The targeting of the proteasomal regulatory subunit S2 by adenovirus E1A causes inhibition of proteasomal activity and increased p53 expression

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Comparative sequence analysis of the largest E1A proteins of human and simian adenoviruses

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Cationic liposome-mediated E1A gene transfer to human breast and ovarian cancer cells and its biologic effects: a phase I clinical trial

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

An adenovirus E1A transcriptional repressor domain functions as an activator when tethered to a promoter

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Complementary functions of E1a conserved region 1 cooperate with conserved region 3 to activate adenovirus serotype 5 early promoters

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Pentapeptide nuclear localization signal in adenovirus E1a.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Re-engineering adenovirus regulatory pathways to enhance oncolytic specificity and efficacy

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

BS69, an adenovirus E1A-associated protein, inhibits the transcriptional activity of c-Myb

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Evaluation of E1-mutant adenoviruses as conditionally replicating agents for cancer therapy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Evidence for a function of CtBP in epithelial gene regulation and anoikis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Tumour suppressive properties of the adenovirus 5 E1A oncogene

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Mutational analysis of the adenovirus E1a gene: the role of transcriptional regulation in transformation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Acetylation by p300 regulates nuclear localization and function of the transcriptional corepressor CtBP2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Proteasome-mediated degradation of transcriptional activators correlates with activation domain potency in vivo

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Amino acids 1-29 of the adenovirus serotypes 12 and 2 E1A proteins interact with rap30 (TF(II)F) and TBP in vitro

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Viral transactivating proteins

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Promoter targeting by adenovirus E1a through interaction with different cellular DNA-binding domains.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Use of deletion and point mutants spanning the coding region of the adenovirus 5 E1A gene to define a domain that is essential for transcriptional activation

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Relationship between the transforming and transcriptional regulatory functions of adenovirus 2 E1a oncogene

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Sequences in E1A proteins of human adenovirus 5 required for cell transformation, repression of a transcriptional enhancer, and induction of proliferating cell nuclear antigen.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Requirement of the C-terminal region of adenovirus E1a for cell transformation in cooperation with E1b

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

PLDLS-dependent interaction of E1A with CtBP: regulation of CtBP nuclear localization and transcriptional functions

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Solution structure of the partially folded high-risk human papilloma virus 45 oncoprotein E7.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Recruitment of TRRAP required for oncogenic transformation by E1A.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Adenoviral E1A protein nuclear import is preferentially mediated by importin alpha3 in vitro.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Phase I trial of intratumoral liposome E1A gene therapy in patients with recurrent breast and head and neck cancer

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

An adenovirus E1a protein region required for transformation and transcriptional repression

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

Enhanced ras oncogene mediated cell transformation and tumorigenesis by adenovirus 2 mutants lacking the C-terminal region of E1a protein.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2493305

An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy

3 September 2018

1 reference

12 December 2020

RACK1 interacts with E1A and rescues E1A-induced yeast growth inhibition and mammalian cell apoptosis

1 reference

12 December 2020

The effect of CtBP1 binding on the structure of the C-terminal region of adenovirus 12 early region 1A

1 reference

12 December 2020

Cellular context of coregulator and adaptor proteins regulates human adenovirus 5 early region 1A-dependent gene activation by the thyroid hormone receptor

1 reference

12 December 2020

Molecular basis of AKAP specificity for PKA regulatory subunits

1 reference

12 December 2020

Acetylation control of the retinoblastoma tumour-suppressor protein

1 reference

12 December 2020

Comparison of the nucleotide sequences of early region E1b DNA of human adenovirus types 12, 7 and 5 (subgroups A, B and C)

1 reference

12 December 2020

Induction of apoptosis by adenovirus type 5 E1A in rat cells requires a proliferation block

1 reference

12 December 2020

The NH(2)-terminal and conserved region 2 domains of adenovirus E1A mediate two distinct mechanisms of tumor suppression

1 reference

12 December 2020

Regulation of the appearance of cytoplasmic RNAs from region 1 of the adenovirus 2 genome

1 reference

12 December 2020

Conserved region 2 of adenovirus E1A has a function distinct from pRb binding required to prevent cell cycle arrest by p16INK4a or p27Kip1

1 reference

12 December 2020

Intracellular localization of adenovirus type 5 tumor antigens in productively infected cells

1 reference

12 December 2020

p300 Transcriptional Repression Is Mediated by SUMO Modification

1 reference

12 December 2020

Evidence for interaction of different eukaryotic transcriptional activators with distinct cellular targets

1 reference

12 December 2020

A family of transcriptional adaptor proteins targeted by the E1A oncoprotein

1 reference

12 December 2020

The adenovirus E1A protein is a potent coactivator for thyroid hormone receptors

1 reference

12 December 2020

Functional interactions within adenovirus E1A protein complexes

1 reference

12 December 2020

Identifiers

DOI

10.1128/JVI.00104-08

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18385237 AND SRC:MED&resulttype=core&format=json

5 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18385237 AND SRC:MED&resulttype=core&format=json

5 January 2020

PubMed publication ID

18385237

1 reference