Osteoclasts - the innate immune cells of the bone (Q37118763)

18 August 2017

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title

Osteoclasts - the innate immune cells of the bone (English)

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18 August 2017

2

Mary Beth Humphrey

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18 August 2017

Yalei Wu

1

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18 August 2017

Mary C Nakamura

series ordinal

3

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18 August 2017

publication date

1 April 2008

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18 August 2017

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18 August 2017

volume

41

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18 August 2017

issue

3

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18 August 2017

page(s)

183-194

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Innate immune recognition

18 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Rapid activation of the medullary bone osteoclast cell surface by parathyroid hormone

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Osteoclasts: what do they do and how do they do it?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

The multiple roles of osteoclasts in host defense: bone remodeling and hematopoietic stem cell mobilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Macrophage receptors and immune recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Interleukin 6. A potential autocrine/paracrine factor in Paget's disease of bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Human osteoclasts express different CXC chemokines depending on cell culture substrate: molecular and immunocytochemical evidence of high levels of CXCL10 and CXCL12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Inflammatory Mediators as Essential Elements in Bone Remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Osteoclast differentiation and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Genetic regulation of osteoclast development and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Osteopetroses and immunodeficiencies in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Successful bone-marrow transplantation for infantile malignant osteopetrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

RANK-L and RANK: T cells, bone loss, and mammalian evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

RANK is essential for osteoclast and lymph node development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Osteoprotegerin deficiency and juvenile Paget's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Sequence variations in the osteoprotegerin gene promoter in patients with postmenopausal osteoporosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

c-Fms and the alphavbeta3 integrin collaborate during osteoclast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

M-CSF mediates TNF-induced inflammatory osteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

TNF/TNFR family members in costimulation of T cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Role of ITAM-containing adapter proteins and their receptors in the immune system and bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

T-cell receptor signal transmission: who gives an ITAM?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Antigen receptor tail clue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

The expanding role for ITAM-based signaling pathways in immune cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

High dose M-CSF partially rescues the Dap12-/- osteoclast phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Mechanistic insight into osteoclast differentiation in osteoimmunology

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

FcR gamma chain deletion results in pleiotrophic effector cell defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Characterization of immortalized osteoclast precursors developed from mice transgenic for both bcl-X(L) and simian virus 40 large T antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Immunophenotypic differences between osteoclasts and macrophage polykaryons: immunohistological distinction and implications for osteoclast ontogeny and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Paired immunoglobulin-like receptor (PIR)-A is involved in activating mast cells through its association with Fc receptor gamma chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

OSCAR is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Involvement of FcRgamma in signal transduction of osteoclast-associated receptor (OSCAR).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

A novel member of the leukocyte receptor complex regulates osteoclast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Fc receptor gamma-chain activation via hOSCAR induces survival and maturation of dendritic cells and modulates Toll-like receptor responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

CNS manifestations of Nasu-Hakola disease: a frontal dementia with bone cysts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Nasu-Hakola syndrome: polycystic lipomembranous osteodysplasia with sclerosing leucoencephalopathy and presenile dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Impaired differentiation of osteoclasts in TREM-2-deficient individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Pattern recognition by TREM-2: binding of anionic ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

The TREM receptor family and signal integration

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Activating and inhibitory functions of DAP12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Regulation of osteoclast function and bone mass by RAGE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

MyD88 but not TRIF is essential for osteoclastogenesis induced by lipopolysaccharide, diacyl lipopeptide, and IL-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Negative regulation of immunoreceptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Deficiency of SHP-1 protein-tyrosine phosphatase activity results in heightened osteoclast function and decreased bone density

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Regulation of osteoprotegerin secretion from primary cultures of human bone marrow stromal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Osteoprotegerin production by human osteoblast lineage cells is stimulated by vitamin D, bone morphogenetic protein-2, and cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Interleukin-1beta and tumor necrosis factor-alpha, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

IL-4 suppresses osteoclast development and mature osteoclast function by a STAT6-dependent mechanism: irreversible inhibition of the differentiation program activated by RANKL

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-kappa B ligand, osteoprotegerin, and receptor activator of NF-kappa B in mouse calvariae

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Characterization of the bone-resorptive effect of interleukin-11 in cultured mouse calvarial bones

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Inhibition of RANKL-induced osteoclast formation in mouse bone marrow cells by IL-12: involvement of IFN-γ possibly induced from non-T cell population

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Interleukin (IL) 18 stimulates osteoclast formation through synovial T cells in rheumatoid arthritis: comparison with IL1 beta and tumour necrosis factor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Signaling crosstalk between RANKL and interferons in osteoclast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Regulation of osteoclastogenesis and RANK expression by TGF-beta1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Transforming growth factor-beta induces expression of receptor activator of NF-kappa B ligand in vascular endothelial cells derived from bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Stimulation of osteoprotegerin (OPG) gene expression by transforming growth factor-beta (TGF-beta). Mapping of the OPG promoter region that mediates TGF-beta effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Role of RANK ligand in mediating increased bone resorption in early postmenopausal women

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

PTH differentially regulates expression of RANKL and OPG.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Cross-talk between the interleukin-6 and prostaglandin E(2) signaling systems results in enhancement of osteoclastogenesis through effects on the osteoprotegerin/receptor activator of nuclear factor-{kappa}B (RANK) ligand/RANK system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Suppression of osteoprotegerin expression by prostaglandin E2 is crucially involved in lipopolysaccharide-induced osteoclast formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

IGF-I regulates osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand in vitro and OPG in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Autoamplification of NFATc1 expression determines its essential role in bone homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Novel osteoclast signaling mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

Cutting Edge: TREM-2 Attenuates Macrophage Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/08916930701693180

10.1080/08916930701693180

21 January 2018

Identifiers

DOI

1 reference

18 August 2017

1 reference