Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4. (Q37114768)

18 August 2017

Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4. (English)

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18 August 2017

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gram-negative bacteria

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9

Shizuo Akira

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Didier Le Roy

object named as

Didier Le Roy

3

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Thierry Roger

object named as

Thierry Roger

1

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Thierry Calandra

object named as

Thierry Calandra

10

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author name string

Céline Froidevaux

2

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18 August 2017

Marlies Knaup Reymond

4

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18 August 2017

Anne-Laure Chanson

5

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18 August 2017

Davide Mauri

6

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18 August 2017

Kim Burns

7

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18 August 2017

Beat Michel Riederer

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18 August 2017

language of work or name

English

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publication date

30 January 2009

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Proceedings of the National Academy of Sciences of the United States of America

18 August 2017

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18 August 2017

106

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18 August 2017

7

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18 August 2017

2348-2352

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TLR4-induced IFN-gamma production increases TLR2 sensitivity and drives Gram-negative sepsis in mice

18 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

Sepsis: rethinking the approach to clinical research

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

Two modes of ligand recognition by TLRs

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

Pathogen recognition and innate immunity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

The epidemiology of sepsis in the United States from 1979 through 2000

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

Innate immune sensing and its roots: the story of endotoxin

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

Recombinant bactericidal/permeability-increasing protein (rBPI21) as adjunctive treatment for children with severe meningococcal sepsis: a randomised trial. rBPI21 Meningococcal Sepsis Study Group

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

Lipopolysaccharide-binding protein as a major plasma protein responsible for endotoxemic shock

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

Isolation of a lipopolysaccharide-binding acute phase reactant from rabbit serum

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

Structure and function of lipopolysaccharide binding protein

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

Regulation of constitutive and microbial pathogen-induced human macrophage migration inhibitory factor (MIF) gene expression

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

TLR4/MD-2 monoclonal antibody therapy affords protection in experimental models of septic shock

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

Contribution of Toll-like receptors to the innate immune response to Gram-negative and Gram-positive bacteria

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

Macrophage migration inhibitory factor promotes innate immune responses by suppressing glucocorticoid-induced expression of mitogen-activated protein kinase phosphatase-1.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

Blocking of responses to endotoxin by E5564 in healthy volunteers with experimental endotoxemia

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

Effective dosing of lipid A analogue E5564 in rats depends on the timing of treatment and the route of Escherichia coli infection.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

Essential role of MD-2 in LPS responsiveness and TLR4 distribution

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2650125

Critical Role of Lipopolysaccharide-Binding Protein and CD14 in Immune Responses against Gram-Negative Bacteria

3 September 2018

1 reference

12 December 2020

MIF regulates innate immune responses through modulation of Toll-like receptor 4

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12 December 2020

Compartmentalization of lipopolysaccharide production correlates with clinical presentation in meningococcal disease

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12 December 2020

1 reference

12 December 2020

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12 December 2020

Crystal structure of CD14 and its implications for lipopolysaccharide signaling

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12 December 2020

Effect of CD14 blockade in rabbits with Escherichia coli pneumonia and sepsis

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0808146106

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18 August 2017

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18 August 2017

PubMed publication ID

19181857

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