Evolutionary divergence of the necroptosis effector MLKL. (Q37098819)

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7 March 2020

title

Evolutionary divergence of the necroptosis effector MLKL (English)

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7 March 2020

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David L Vaux

9

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7 March 2020

John Silke

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7 March 2020

James Murphy

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author name string

M C Tanzer

1

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7 March 2020

I Matti

2

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7 March 2020

J M Hildebrand

3

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7 March 2020

S N Young

4

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7 March 2020

A Wardak

5

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7 March 2020

A Tripaydonis

6

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7 March 2020

A L Mildenhall

8

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7 March 2020

J E Vince

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P E Czabotar

11

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publication date

12 February 2016

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Cell Death & Differentiation

7 March 2020

published in

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volume

23

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issue

7

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7 March 2020

page(s)

1185-1197

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Post-translational control of RIPK3 and MLKL mediated necroptotic cell death

7 March 2020

cites work

1 reference

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HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death.

14 September 2017

1 reference

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A tale of two domains - a structural perspective of the pseudokinase, MLKL.

14 September 2017

1 reference

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Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946887

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946887

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

14 September 2017

1 reference

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A plug release mechanism for membrane permeation by MLKL.

14 September 2017

1 reference

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RIPK1- and RIPK3-induced cell death mode is determined by target availability

14 September 2017

1 reference

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MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946887

Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946887

Necroptosis induced by RIPK3 requires MLKL but not Drp1.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946887

14 September 2017

1 reference

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Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946887

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946887

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946887

Widespread mitochondrial depletion via mitophagy does not compromise necroptosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946887

Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946887

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946887

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946887

Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946887

Diverse sequence determinants control human and mouse receptor interacting protein 3 (RIP3) and mixed lineage kinase domain-like (MLKL) interaction in necroptotic signaling

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946887

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946887

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase

14 September 2017

1 reference

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Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

14 September 2017

1 reference

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Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946887

Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4946887

Identification of RIP1 kinase as a specific cellular target of necrostatins

14 September 2017

1 reference

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Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

14 September 2017

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Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop

14 September 2017

1 reference

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Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it.

29 September 2017

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Reactive oxygen species regulate Smac mimetic/TNFα-induced necroptotic signaling and cell death

3 September 2018

1 reference

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Quantitative Analysis of Phospholipids in Functionally Important Membrane Domains from RBL-2H3 Mast Cells Using Tandem High-Resolution Mass Spectrometry†

3 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038/CDD.2015.169

21 January 2018

Identifiers

DOI

10.1038/CDD.2015.169

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26868910 AND SRC:MED&resulttype=core&format=json

7 March 2020

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7 March 2020

PubMed publication ID

26868910

1 reference