Therapeutic margins in a novel preclinical model of retinitis pigmentosa. (Q37093907)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23946405 AND SRC:MED&resulttype=core&format=json

7 March 2020

title

Therapeutic margins in a novel preclinical model of retinitis pigmentosa (English)

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7 March 2020

4

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7 March 2020

author name string

Richard J Davis

1

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7 March 2020

Chun-Wei Hsu

2

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7 March 2020

Yi-Ting Tsai

3

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7 March 2020

Javier Sancho-Pelluz

5

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7 March 2020

Chyuan-Sheng Lin

6

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7 March 2020

Stephen H Tsang

7

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7 March 2020

language of work or name

English

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publication date

1 August 2013

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7 March 2020

published in

Journal of Neuroscience

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7 March 2020

volume

33

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7 March 2020

issue

33

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7 March 2020

page(s)

13475-13483

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Origin of fundus hyperautofluorescent spots and their role in retinal degeneration in a mouse model of Goldmann-Favre syndrome

7 March 2020

cites work

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Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement

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Gene therapy provides long-term visual function in a pre-clinical model of retinitis pigmentosa

29 September 2017

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Restoration of Vision in the pde6β-deficient Dog, a Large Animal Model of Rod-cone Dystrophy

29 September 2017

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Diagnostic imaging in patients with retinitis pigmentosa

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Mice with a D190N Mutation in the Gene Encoding Rhodopsin: A Model for Human Autosomal-Dominant Retinitis Pigmentosa

29 September 2017

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Therapeutic challenges to retinitis pigmentosa: from neuroprotection to gene therapy.

29 September 2017

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Structural and functional changes associated with normal and abnormal fundus autofluorescence in patients with retinitis pigmentosa

29 September 2017

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Lentivirus-mediated expression of cDNA and shRNA slows degeneration in retinitis pigmentosa

29 September 2017

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T cell responses in experimental viral retinitis: mechanisms, peculiarities and implications for gene therapy with viral vectors.

29 September 2017

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Long-term retinal function and structure rescue using capsid mutant AAV8 vector in the rd10 mouse, a model of recessive retinitis pigmentosa.

29 September 2017

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Gene therapy for vision loss -- recent developments

29 September 2017

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shRNA knockdown of guanylate cyclase 2e or cyclic nucleotide gated channel alpha 1 increases photoreceptor survival in a cGMP phosphodiesterase mouse model of retinitis pigmentosa

29 September 2017

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Gene therapy for ocular diseases

29 September 2017

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Autosomal-recessive early-onset retinitis pigmentosa caused by a mutation in PDE6G, the gene encoding the gamma subunit of rod cGMP phosphodiesterase

29 September 2017

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Adeno-associated virus vector integration

29 September 2017

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Structural assessment of hyperautofluorescent ring in patients with retinitis pigmentosa

29 September 2017

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Cellular origin of fundus autofluorescence in patients and mice with a defective NR2E3 gene

29 September 2017

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Innate immune recognition of viruses and viral vectors

29 September 2017

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High-efficiency transduction of the mouse retina by tyrosine-mutant AAV serotype vectors

29 September 2017

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A novel mutation and phenotypes in phosphodiesterase 6 deficiency

29 September 2017

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Functional rescue of degenerating photoreceptors in mice homozygous for a hypomorphic cGMP phosphodiesterase 6 b allele (Pde6bH620Q).

29 September 2017

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AAV-mediated gene therapy for retinal degeneration in the rd10 mouse containing a recessive PDEbeta mutation

29 September 2017

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Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice

29 September 2017

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Functional characteristics of patients with retinal dystrophy that manifest abnormal parafoveal annuli of high density fundus autofluorescence; a review and update

29 September 2017

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Perspective on genes and mutations causing retinitis pigmentosa

29 September 2017

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29 September 2017

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Retinal organization in the retinal degeneration 10 (rd10) mutant mouse: a morphological and ERG study

29 September 2017

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Directing neuron-specific transgene expression in the mouse CNS.

29 September 2017

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Evidence for glutamate-mediated excitotoxic mechanisms during photoreceptor degeneration in the rd1 mouse retina

29 September 2017

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Photoreceptor degeneration and dysfunction in aging and age-related maculopathy

29 September 2017

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Retinal degeneration mutants in the mouse

29 September 2017

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Delays in rod-mediated dark adaptation in early age-related maculopathy

29 September 2017

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A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA

29 September 2017

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Tetracycline-inducible system for photoreceptor-specific gene expression

29 September 2017

1 reference

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Spare the rods, save the cones in aging and age-related maculopathy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3742933

Psychophysical evidence for rod vulnerability in age-related macular degeneration

29 September 2017

1 reference

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Frequency of mutations in the gene encoding the alpha subunit of rod cGMP-phosphodiesterase in autosomal recessive retinitis pigmentosa

29 September 2017

1 reference

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Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase

29 September 2017

1 reference

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Spatio-temporally controlled site-specific somatic mutagenesis in the mouse.

29 September 2017

1 reference

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Retinal degeneration in mice lacking the gamma subunit of the rod cGMP phosphodiesterase

29 September 2017

1 reference

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Mutations in the PDE6B gene in autosomal recessive retinitis pigmentosa

29 September 2017

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Retinitis pigmentosa. The Friedenwald Lecture

29 September 2017

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Recessive mutations in the gene encoding the beta-subunit of rod phosphodiesterase in patients with retinitis pigmentosa

29 September 2017

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Evaluation of the gene encoding the gamma subunit of rod phosphodiesterase in retinitis pigmentosa

29 September 2017

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Retinitis pigmentosa and allied diseases. Implications of genetic heterogeneity.

29 September 2017

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Retinal photoreceptor dystrophies LI. Edward Jackson Memorial Lecture

29 September 2017

1 reference

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Mutation spectrum of the gene encoding the beta subunit of rod phosphodiesterase among patients with autosomal recessive retinitis pigmentosa

29 September 2017

1 reference

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Autosomal recessive retinitis pigmentosa caused by mutations in the alpha subunit of rod cGMP phosphodiesterase

29 September 2017

1 reference

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Targeted oncogene activation by site-specific recombination in transgenic mice

29 September 2017

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Subretinal injection of gene therapy vectors and stem cells in the perinatal mouse eye.

29 September 2017

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Positive-negative selection gene targeting with the diphtheria toxin A-chain gene in mouse embryonic stem cells.

27 June 2018

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Proteoglycans in the mouse interphotoreceptor matrix. II. Origin and development of proteoglycans

27 June 2018

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Conditions for greater survival of neonatally thymectomized Swiss mice (author's transl)

27 June 2018

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Progressive Constriction of the Hyperautofluorescent Ring in Retinitis Pigmentosa

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3742933

Toxicity of ligand-dependent Cre recombinases and generation of a conditional Cre deleter mouse allowing mosaic recombination in peripheral tissues

3 September 2018

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Genotype-phenotype correlation of mouse pde6b mutations

3 September 2018

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Lentiviral vector-mediated gene transfer in adult mouse photoreceptors is impaired by the presence of a physical barrier

3 September 2018

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A noninvasive genetic/pharmacologic strategy for visualizing cell morphology and clonal relationships in the mouse.

3 September 2018

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A diffusible factor from normal retinal cells promotes rod photoreceptor survival in an in vitro model of retinitis pigmentosa

3 September 2018

1 reference

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Inducible site-specific recombination in the brain

3 September 2018

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Effect of hypothermia and ether anesthesia on the dispositions of creatinine and urea in mice

3 September 2018

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Non-Cell-Autonomous Photoreceptor Degeneration inrdsMutant Mice Mosaic for Expression of a Rescue Transgene

3 September 2018

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12 December 2020

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12 December 2020

Racial/ethnic differences in age-related maculopathy. Third National Health and Nutrition Examination Survey

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12 December 2020

AAV-mediated gene replacement, either alone or in combination with physical and pharmacological agents, results in partial and transient protection from photoreceptor degeneration associated with betaPDE deficiency

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12 December 2020

Stage-specific binding of peanut agglutinin to aggregates of degenerating photoreceptor cells in the rd mouse retina

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12 December 2020

10.1523/JNEUROSCI.0419-13.2013

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23946405 AND SRC:MED&resulttype=core&format=json

7 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23946405 AND SRC:MED&resulttype=core&format=json

7 March 2020

PubMed publication ID

23946405

1 reference