HIV-1 reverse transcription initiation: a potential target for novel antivirals? (Q37078563)

18 August 2017

1 reference

title

HIV-1 reverse transcription initiation: a potential target for novel antivirals? (English)

1 reference

18 August 2017

0 references

1

Truus E M Abbink

1 reference

18 August 2017

Ben Berkhout

2

1 reference

18 August 2017

publication date

6 February 2008

1 reference

18 August 2017

1 reference

18 August 2017

volume

134

1 reference

18 August 2017

issue

1-2

1 reference

18 August 2017

page(s)

4-18

1 reference

HIV-1 reverse transcription: close encounters between the viral genome and a cellular tRNA.

18 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Forced selection of a human immunodeficiency virus type 1 variant that uses a non-self tRNA primer for reverse transcription: involvement of viral RNA sequences and the reverse transcriptase enzyme

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Restoration of tRNA3Lys-primed(-)-strand DNA synthesis to an HIV-1 reverse transcriptase mutant with extended tRNAs. Implications for retroviral replication

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

DNA found in human immunodeficiency virus type 1 particles may not be required for infectivity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Role of post-transcriptional modifications of primer tRNALys,3 in the fidelity and efficacy of plus strand DNA transfer during HIV-1 reverse transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Interaction of HIV-1 reverse transcriptase with a synthetic form of its replication primer, tRNALys,3

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Analysis of the Interactions of HIV1 Replication Primer tRNALys,3 with Nucleocapsid Protein and Reverse Transcriptase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

The tRNA primer activation signal in the human immunodeficiency virus type 1 genome is important for initiation and processive elongation of reverse transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Switching the in vitro tRNA usage of HIV-1 by simultaneous adaptation of the PBS and PAS.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Initiation of HIV-1 reverse transcription is regulated by a primer activation signal

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

A structured RNA motif is involved in correct placement of the tRNA(3)(Lys) primer onto the human immunodeficiency virus genome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Molecular analysis of the second template switch during reverse transcription of the HIV RNA template

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

The primer binding site on the RNA genome of human and simian immunodeficiency viruses is flanked by an upstream hairpin structure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Retrovirus-mediated insertion of expressed and non-expressed genes at identical chromosomal locations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Retrovirus-specific packaging of aminoacyl-tRNA synthetases with cognate primer tRNAs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Ability of wild-type and mutant lysyl-tRNA synthetase to facilitate tRNA(Lys) incorporation into human immunodeficiency virus type 1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Roles of Pr55(gag) and NCp7 in tRNA(3)(Lys) genomic placement and the initiation step of reverse transcription in human immunodeficiency virus type 1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Incorporation of lysyl-tRNA synthetase into human immunodeficiency virus type 1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

The connection domain in reverse transcriptase facilitates the in vivo annealing of tRNALys3 to HIV-1 genomic RNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

HIV-1 Reverse Transcription A Termination Step at the Center of the Genome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

The crystal structures of T. thermophilus lysyl-tRNA synthetase complexed with E. coli tRNA(Lys) and a T. thermophilus tRNA(Lys) transcript: anticodon recognition and conformational changes upon binding of a lysyl-adenylate analogue

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Properties, functions, and drug targeting of the multifunctional nucleocapsid protein of the human immunodeficiency virus.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Sequence variation of the human immunodeficiency virus primer-binding site suggests the use of an alternative tRNA(Lys) molecule in reverse transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Human immunodeficiency virus uses tRNA(Lys,3) as primer for reverse transcription in HeLa-CD4 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Alternative tRNA priming of human immunodeficiency virus type 1 reverse transcription explains sequence variation in the primer-binding site that has been attributed to APOBEC3G activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Viral RNA annealing activities of human immunodeficiency virus type 1 nucleocapsid protein require only peptide domains outside the zinc fingers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Studies on primer binding of HIV-1 reverse transcriptase using a fluorescent probe

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Functional differences between the human LINE retrotransposon and retroviral reverse transcriptases for invivo mRNA reverse transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Characterization of highly immunogenic p66/p51 as the reverse transcriptase of HTLV-III/LAV.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Cross-linking localization of a HIV-1 reverse transcriptase peptide involved in the binding of primer tRNALys3.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Inhibition of human immunodeficiency virus type 1 replication with artificial transcription factors targeting the highly conserved primer-binding site

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Initiation of HIV-2 reverse transcription: a secondary structure model of the RNA-tRNA(Lys3) duplex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Effect of altering the tRNA(Lys)(3) concentration in human immunodeficiency virus type 1 upon its annealing to viral RNA, GagPol incorporation, and viral infectivity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Specific inhibition of the synthesis of human lysyl-tRNA synthetase results in decreases in tRNA(Lys) incorporation, tRNA(3)(Lys) annealing to viral RNA, and viral infectivity in human immunodeficiency virus type 1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Genome organization and transactivation of the human immunodeficiency virus type 2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Cellular distribution of Lysyl-tRNA synthetase and its interaction with Gag during human immunodeficiency virus type 1 assembly

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Mechanistic insights into the kinetics of HIV-1 nucleocapsid protein-facilitated tRNA annealing to the primer binding site

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Interaction of tryptophan tRNA and avian myeloblastosis virus reverse transcriptase: further characterization of the binding reaction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Vif is a RNA chaperone that could temporally regulate RNA dimerization and the early steps of HIV-1 reverse transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Fully-spliced HIV-1 RNAs are reverse transcribed with similar efficiencies as the genomic RNA in virions and cells, but more efficiently in AZT-treated cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Mutations in the central polypurine tract of HIV-1 result in delayed replication

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

On the importance of the primer activation signal for initiation of tRNA(lys3)-primed reverse transcription of the HIV-1 RNA genome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Initiation of reverse transcription of HIV-1: secondary structure of the HIV-1 RNA/tRNA(3Lys) (template/primer)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Correlation between tRNALys3 aminoacylation and its incorporation into HIV-1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

The interaction between HIV-1 Gag and human lysyl-tRNA synthetase during viral assembly

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Variable tRNA content in HIV-1IIIB.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Indolopyridones inhibit human immunodeficiency virus reverse transcriptase with a novel mechanism of action

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Viral hijacking of mitochondrial lysyl-tRNA synthetase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Sequences within Pr160gag-pol affecting the selective packaging of primer tRNA(Lys3) into HIV-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

The ability of the HIV-1 AAUAAA signal to bind polyadenylation factors is controlled by local RNA structure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Reverse transcriptase of human immunodeficiency virus can use either human tRNA(3Lys) or Escherichia coli tRNA(2Gln) as a primer in an in vitro primer-utilization assay

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

In VitroCharacterization of the Interaction between HIV-1 Gag and Human Lysyl-tRNA Synthetase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Critical role of helix 4 of HIV-1 capsid C-terminal domain in interactions with human lysyl-tRNA synthetase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Nucleic acid chaperone activity of HIV-1 nucleocapsid protein: critical role in reverse transcription and molecular mechanism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Selection of functional tRNA primers and primer binding site sequences from a retroviral combinatorial library: identification of new functional tRNA primers in murine leukemia virus replication

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

tRNAs as primer of reverse transcriptases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Human immunodeficiency virus bearing a disrupted central DNA flap is pathogenic in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Synthetic tRNALys,3 as the replication primer for the HIV-1HXB2 and HIV-1Mal genomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Site-specific crosslinking of 4-thiouridine-modified human tRNA(3Lys) to reverse transcriptase from human immunodeficiency virus type I.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Replication of avian sarcoma virus in vivo requires an interaction between the viral RNA and the TpsiC loop of the tRNA(Trp) primer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

The availability of the primer activation signal (PAS) affects the efficiency of HIV-1 reverse transcription initiation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Structural requirements for the binding of tRNA Lys3 to reverse transcriptase of the human immunodeficiency virus type 1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

HIV-1 reverse transcriptase discriminates against non-self tRNA primers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

tRNA isoacceptor preference prior to retrovirus Gag-Pol junction links primer selection and viral translation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Effects of tRNA3Lys aminoacylation on the initiation of HIV-1 reverse transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Interactions with tRNALysinduce important structural changes in human immunodeficiency virus reverse transcriptase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Processing of an HIV replication intermediate by the human DNA replication enzyme FEN1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Preferential interaction of human immunodeficiency virus reverse transcriptase with two regions of primer tRNA(Lys) as evidenced by footprinting studies and inhibition with synthetic oligoribonucleotides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Localization of a polynucleotide binding region in the HIV-1 reverse transcriptase: implications for primer binding

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Compilation of tRNA sequences and sequences of tRNA genes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Structural bases of the annealing of primer tRNA(3Lys) to the HIV-1 viral RNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Heteronuclear NMR studies of the interaction of tRNA3Lys with HIV-1 nucleocapsid protein11Edited by M. F. Summers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

The annealing mechanism of HIV-1 reverse transcription primer onto the viral genome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Anti HIV-1 virucidal activity of polyamide nucleic acid-membrane transducing peptide conjugates targeted to primer binding site of HIV-1 genome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Frequent dual initiation in human immunodeficiency virus-based vectors containing two primer-binding sites: a quantitative in vivo assay for function of initiation complexes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Nucleotide sequence of the AIDS virus, LAV

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

The HIV-1 reverse transcriptase mutants G190S and G190A, which confer resistance to non-nucleoside reverse transcriptase inhibitors, demonstrate reductions in RNase H activity and DNA synthesis from tRNA(Lys, 3) that correlate with reductions in rep

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

An expanded model of replicating human immunodeficiency virus reverse transcriptase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

TRIM28 mediates primer binding site-targeted silencing of murine leukemia virus in embryonic cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

The G490E mutation in reverse transcriptase does not impact tRNA primer selection by HIV-1 with altered PBS and A-loop

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Few mutations in the 5' leader region mediate fitness recovery of debilitated human immunodeficiency type 1 viruses

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

The intragenic enhancer of human immunodeficiency virus type 1 contains functional AP-1 binding sites.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

Effects of 3'-deoxynucleoside 5'-triphosphate concentrations on chain termination by nucleoside analogs during human immunodeficiency virus type 1 reverse transcription of minus-strand strong-stop DNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

7 January 2021

Efficient polyadenylation within the human immunodeficiency virus type 1 long terminal repeat requires flanking U3-specific sequences

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

7 January 2021

Overlapping retrovirus U5 sequence elements are required for efficient integration and initiation of reverse transcription

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

7 January 2021

A retroviral RNA secondary structure required for efficient initiation of reverse transcription

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

7 January 2021

Isolation of a recombinant murine leukemia virus utilizing a new primer tRNA.

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

7 January 2021

Reduced replication of human immunodeficiency virus type 1 mutants that use reverse transcription primers other than the natural tRNA(3Lys)

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

7 January 2021

The human immunodeficiency virus type 1 Gag polyprotein has nucleic acid chaperone activity: possible role in dimerization of genomic RNA and placement of tRNA on the primer binding site

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

7 January 2021

Incorporation of excess wild-type and mutant tRNA(3Lys) into human immunodeficiency virus type 1.

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

7 January 2021

Primer tRNA3Lys on the viral genome exists in unextended and two-base extended forms within mature human immunodeficiency virus type 1.

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

7 January 2021

Identification of tRNAs incorporated into wild-type and mutant human immunodeficiency virus type 1

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

7 January 2021

Effect of polymerase mutations on packaging of primer tRNAPro during murine leukemia virus assembly

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

7 January 2021

Mutated primer binding sites interacting with different tRNAs allow efficient murine leukemia virus replication

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

7 January 2021

Role of Pr160gag-pol in mediating the selective incorporation of tRNA(Lys) into human immunodeficiency virus type 1 particles

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

7 January 2021

Reverse transcriptase as the major determinant for selective packaging of tRNA's into Avian sarcoma virus particles

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

7 January 2021

Small RNAs of Rous sarcoma virus: characterization by two-dimensional polyacrylamide gel electrophoresis and fingerprint analysis

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

7 January 2021

Recombination between a defective retrovirus and homologous sequences in host DNA: reversion by patch repair

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

7 January 2021

Human immunodeficiency virus type 1 can use different tRNAs as primers for reverse transcription but selectively maintains a primer binding site complementary to tRNA(3Lys)

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

7 January 2021

Transfer RNA into RNA tumor viruses

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

7 January 2021

Primer tRNAs for reverse transcription

1 reference

https://api.crossref.org/works/10.1016/J.VIRUSRES.2007.12.009

7 January 2021

10.1016/J.VIRUSRES.2007.12.009

Identifiers

DOI

1 reference

18 August 2017

1 reference