Role of OATP transporters in the disposition of drugs (Q37074085)

18 August 2017

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title

Role of OATP transporters in the disposition of drugs (English)

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18 August 2017

Mikko Niemi

1

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publication date

1 July 2007

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18 August 2017

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18 August 2017

volume

8

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18 August 2017

issue

7

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18 August 2017

page(s)

787-802

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Transporters and drug therapy: implications for drug disposition and disease

18 August 2017

cites work

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Transporters as a determinant of drug clearance and tissue distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Pharmacogenomics of the OATP and OAT families

21 January 2018

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Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties

21 January 2018

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https://api.crossref.org/works/10.2217/14622416.8.7.787

Pharmacogenomics of human OATP transporters

21 January 2018

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https://api.crossref.org/works/10.2217/14622416.8.7.787

Role of the liver-specific transporters OATP1B1 and OATP1B3 in governing drug elimination

21 January 2018

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https://api.crossref.org/works/10.2217/14622416.8.7.787

Implications of genetic polymorphisms in drug transporters for pharmacotherapy

21 January 2018

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https://api.crossref.org/works/10.2217/14622416.8.7.787

Organic anion transporting polypeptides of the OATP/SLCO superfamily: identification of new members in nonmammalian species, comparative modeling and a potential transport mode.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver

21 January 2018

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https://api.crossref.org/works/10.2217/14622416.8.7.787

Steroid sulfatase (STS) expression in the human temporal lobe: enzyme activity, mRNA expression and immunohistochemistry study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Intestinal drug transporter expression and the impact of grapefruit juice in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Identification of influx transporter for the quinolone antibacterial agent levofloxacin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase

21 January 2018

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https://api.crossref.org/works/10.2217/14622416.8.7.787

Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics.

21 January 2018

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Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Identification of Thyroid Hormone Transporters in Humans: Different Molecules Are Involved in a Tissue-Specific Manner

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Itraconazole increases but grapefruit juice greatly decreases plasma concentrations of celiprolol

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Orange juice substantially reduces the bioavailability of the beta-adrenergic-blocking agent celiprolol

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15 C1007G, by using transient expression systems of HeLa and HEK293 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

The effect of gemfibrozil on the pharmacokinetics of rosuvastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Inhibition of Organic Anion Transporting Polypeptide-Mediated Hepatic Uptake Is the Major Determinant in the Pharmacokinetic Interaction between Bosentan and Cyclosporin A in the Rat

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Inhibitory and inductive effects of rifampin on the pharmacokinetics of bosentan in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Hepatic uptake of the novel antifungal agent caspofungin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Vectorial transport of enalapril by Oatp1a1/Mrp2 and OATP1B1 and OATP1B3/MRP2 in rat and human livers.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

OATP1B1, OATP1B3, and mrp2 are involved in hepatobiliary transport of olmesartan, a novel angiotensin II blocker

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin: in vitro evidence and effect of single nucleotide polymorphisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Fexofenadine pharmacokinetics are associated with a polymorphism of the SLCO1B1 gene (encoding OATP1B1)

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Pharmacokinetics and pharmacodynamics of pravastatin in pediatric and adolescent cardiac transplant recipients on a regimen of triple immunosuppression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Combined therapy with atorvastatin and calcineurin inhibitors: no interactions with tacrolimus

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Changes in lipid metabolism and effect of simvastatin in renal transplant recipients induced by cyclosporine or tacrolimus

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Pharmacokinetics and pharmacodynamics of fluvastatin in heart transplant recipients taking cyclosporine A.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Bilateral pharmacokinetic interaction between cyclosporine A and atorvastatin in renal transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Cyclosporine markedly raises the plasma concentrations of repaglinide

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Combined oral cyclosporin and methotrexate therapy in patients with rheumatoid arthritis elevates methotrexate levels and reduces 7-hydroxymethotrexate levels when compared with methotrexate alone

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Gemfibrozil greatly increases plasma concentrations of cerivastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Plasma concentrations of active lovastatin acid are markedly increased by gemfibrozil but not by bezafibrate

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Gemfibrozil considerably increases the plasma concentrations of rosiglitazone

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: implications for drug-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug inter

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Pharmacokinetic interactions with rifampicin : clinical relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Rifampin markedly decreases and gemfibrozil increases the plasma concentrations of atorvastatin and its metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Effect of rifampicin on pravastatin pharmacokinetics in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Inhibition of human organic anion transporting polypeptide OATP 1B1 as a mechanism of drug-induced hyperbilirubinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Drug-drug interaction between pitavastatin and various drugs via OATP1B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

The influence of macrolide antibiotics on the uptake of organic anions and drugs mediated by OATP1B1 and OATP1B3.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Functional analysis of single nucleotide polymorphisms of hepatic organic anion transporter OATP1B1 (OATP-C).

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Effect of OATP1B1 (SLCO1B1) variant alleles on the pharmacokinetics of pitavastatin in healthy volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Evaluation of inhibitory drug interactions during drug development: genetic polymorphisms must be considered

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Acute effects of pravastatin on cholesterol synthesis are associated with SLCO1B1 (encoding OATP1B1) haplotype *17.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Effect of genetic polymorphism of OATP-C (SLCO1B1) on lipid-lowering response to HMG-CoA reductase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Variants in the SLCO1B3 gene: interethnic distribution and association with paclitaxel pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

21 January 2018

Ins and outs of taxanes

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8).

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Organic anion transporting polypeptide 2B1 is a high-affinity transporter for atorvastatin and is expressed in the human heart

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Active influx transport is mediated by members of the organic anion transporting polypeptide family in human epidermal keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Effects of clarithromycin and grapefruit juice on the pharmacokinetics of glibenclamide

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT)

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Mutagenesis of the N-glycosylation site of hNaSi-1 reduces transport activity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Predominant contribution of OATP1B3 to the hepatic uptake of telmisartan, an angiotensin II receptor antagonist, in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Functional Characterization of pH-Sensitive Organic Anion Transporting Polypeptide OATP-B in Human

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Frequencies of single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide 1B1 SLCO1B1 gene in a Finnish population

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

SLCO1B1 polymorphism and sex affect the pharmacokinetics of pravastatin but not fluvastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Impact of the SLCO1B1 polymorphism on the pharmacokinetics and lipid-lowering efficacy of multiple-dose pravastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

Effect of SLCO1B1 polymorphism on induction of CYP3A4 by rifampicin

21 January 2018

1 reference

https://api.crossref.org/works/10.2217/14622416.8.7.787

21 January 2018

Identifiers

DOI

10.2217/14622416.8.7.787

1 reference

release_56did24fgfabfpgzdv44sar33a

18 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/56did24fgfabfpgzdv44sar33a

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference