Induction of genetic instability by gain-of-function p53 cancer mutants (Q37068656)

18 August 2017

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title

Induction of genetic instability by gain-of-function p53 cancer mutants (English)

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18 August 2017

Y Xu

1

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18 August 2017

language of work or name

English

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publication date

28 January 2008

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18 August 2017

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18 August 2017

volume

27

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18 August 2017

issue

25

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18 August 2017

page(s)

3501-3507

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

18 August 2017

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The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality

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Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair

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p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression

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Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool.

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p53 suppresses the self-renewal of adult neural stem cells.

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p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.

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p53 exon 5 mutations as a prognostic indicator of shortened survival in non-small-cell lung cancer

21 January 2018

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p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

21 January 2018

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A global map of p53 transcription-factor binding sites in the human genome

21 January 2018

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Transcription regulation by mutant p53.

21 January 2018

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A new role for p53 in maintaining genetic stability in embryonic stem cells

21 January 2018

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DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis

21 January 2018

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Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

21 January 2018

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Dual roles of ATM in the cellular response to radiation and in cell growth control.

21 January 2018

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Complicating the complexity of p53

21 January 2018

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ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

21 January 2018

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PUMA induces the rapid apoptosis of colorectal cancer cells

21 January 2018

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Chromatin structural elements and chromosomal translocations in leukemia

21 January 2018

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Microarray Analysis of p53-Mediated Transcription: Mutli-Thousand Piece Puzzle or Invitation to Collective Thinking?

21 January 2018

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Wild-type p53 activates transcription in vitro

21 January 2018

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Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors

21 January 2018

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7 January 2021

Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family

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7 January 2021

The Thousand Doors that Lead to Death: p53-Dependent Repression and Apoptosis

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7 January 2021

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

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7 January 2021

The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation.

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7 January 2021

Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants

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7 January 2021

Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1211023

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18 August 2017

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