Agonist binding, agonist affinity and agonist efficacy at G protein-coupled receptors (Q37068652)

18 August 2017

1 reference

title

Agonist binding, agonist affinity and agonist efficacy at G protein-coupled receptors (English)

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G protein-coupled receptor

18 August 2017

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author name string

P G Strange

series ordinal

1

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PMC publication ID

2437915

18 August 2017

language of work or name

English

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publication date

28 January 2008

1 reference

British Journal of Pharmacology

18 August 2017

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18 August 2017

153

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18 August 2017

7

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18 August 2017

1353-1363

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Estimation of agonist activity at G protein-coupled receptors: analysis of M2 muscarinic receptor signaling through Gi/o,Gs, and G15.

18 August 2017

1 reference

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29 September 2017

1 reference

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Pharmacogenomic and structural analysis of constitutive g protein-coupled receptor activity.

29 September 2017

1 reference

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The receptor concept: pharmacology's big idea

29 September 2017

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29 September 2017

1 reference

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G-protein coupled receptor assays: to measure affinity or efficacy that is the question

29 September 2017

1 reference

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Inverse agonist activity at the alpha(2A)-adrenergic receptor.

29 September 2017

1 reference

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29 September 2017

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G-protein coupled receptors: conformations and states

29 September 2017

1 reference

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A simple method for estimation of agonist activity at receptor subtypes: comparison of native and cloned M3 muscarinic receptors in guinea pig ileum and transfected cells

29 September 2017

1 reference

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Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

29 September 2017

1 reference

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Somatostatin5 receptor-mediated [35S]guanosine-5'-O-(3-thio)triphosphate binding: agonist potencies and the influence of sodium chloride on intrinsic activity.

29 September 2017

1 reference

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Characterisation of a cloned human 5-HT1A receptor cell line using [35S]GTP gamma S binding

29 September 2017

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29 September 2017

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29 September 2017

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A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model

29 September 2017

1 reference

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The two-state model of receptor activation

29 September 2017

1 reference

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A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor

29 September 2017

1 reference

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Identification of residues required for ligand binding to the beta-adrenergic receptor

29 September 2017

1 reference

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Site-directed mutagenesis and continuous expression of human beta-adrenergic receptors. Identification of a conserved aspartate residue involved in agonist binding and receptor activation

29 September 2017

1 reference

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Agonist potency and apparent affinity: interpretation using classical and steady-state ternary-complex models

29 September 2017

1 reference

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Errors in agonist affinity estimation: do they and should they occur in isolated tissue experiments?

29 September 2017

1 reference

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Transphosphorylation and G protein activation

29 September 2017

1 reference

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Pivotal role for aspartate-80 in the regulation of dopamine D2 receptor affinity for drugs and inhibition of adenylyl cyclase

29 September 2017

1 reference

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Site-directed mutagenesis of alpha 2A-adrenergic receptors: identification of amino acids involved in ligand binding and receptor activation by agonists

29 September 2017

1 reference

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Receptor interactions of imidazolines. II. Affinities and efficacies of hydroxy-substituted tolazoline derivatives in rat aorta

29 September 2017

1 reference

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Receptor interactions of imidazolines. I. Affinity and efficacy for alpha adrenergic receptors in rat aorta

29 September 2017

1 reference

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Dissociation constants and relative efficacies of agonists acting on alpha adrenergic receptors in rabbit aorta

29 September 2017

1 reference

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Mutation of an aspartate residue highly conserved among G-protein-coupled receptors results in nonreciprocal disruption of alpha 2-adrenergic receptor-G-protein interactions. A negative charge at amino acid residue 79 forecasts alpha 2A-adrenergic r

29 September 2017

1 reference

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Assays for enhanced activity of low efficacy partial agonists at the D(2) dopamine receptor

29 September 2017

1 reference

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Analysis of molecular determinants of affinity and relative efficacy of a series of R- and S-2-(dipropylamino)tetralins at the 5-HT1A serotonin receptor

27 June 2018

1 reference

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Nonlinear analysis of partial dopamine agonist effects on cAMP in C6 glioma cells

27 June 2018

1 reference

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Agonist binding to G-protein coupled receptors

27 June 2018

1 reference

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Mechanisms of agonism and inverse agonism at serotonin 5-HT1A receptors

27 June 2018

1 reference

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Conserved polar residues in the transmembrane domain of the human tachykinin NK2 receptor: functional roles and structural implications

27 June 2018

1 reference

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Characterization of recombinant human serotonin 5HT1A receptors expressed in Chinese hamster ovary cells. [3H]spiperone discriminates between the G-protein-coupled and -uncoupled forms

27 June 2018

1 reference

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Site-directed mutagenesis of the serotonin 5-hydroxytrypamine2 receptor: identification of amino acids necessary for ligand binding and receptor activation

27 June 2018

1 reference

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Operational models of pharmacological agonism.

27 June 2018

1 reference

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Aromatic and benzylic hydroxyl substitution of imidazolines and phenethylamines: differences in activity at alpha-1 and alpha-2 adrenergic receptors

27 June 2018

1 reference

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27 June 2018

1 reference

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On the measurement of the affinity of partial agonists for receptors

27 June 2018

1 reference

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Coupling of muscarinic receptors to adenylate cyclase in the rabbit myocardium: effects of receptor inactivation.

27 June 2018

1 reference

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Site-directed mutagenesis of m1 muscarinic acetylcholine receptors: conserved aspartic acids play important roles in receptor function

27 June 2018

1 reference

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Pharmacological estimation of agonist affinity: detection of errors that may be caused by the operation of receptor isomerisation or ternary complex mechanisms

27 June 2018

1 reference

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Spontaneous association between opioid receptors and GTP-binding regulatory proteins in native membranes: specific regulation by antagonists and sodium ions

27 June 2018

1 reference

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Interpretation of agonist affinity estimations: the question of distributed receptor states

27 June 2018

1 reference

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Interactions of agonists with M2 and M4 muscarinic receptor subtypes mediating cyclic AMP inhibition

27 June 2018

1 reference

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27 June 2018

1 reference

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Receptor interactions of imidazolines: alpha-adrenoceptors of rat and rabbit aortae differentiated by relative potencies, affinities and efficacies of imidazoline agonists

27 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038/SJ.BJP.0707672

An activation switch in the rhodopsin family of G protein-coupled receptors: the thyrotropin receptor

21 January 2018

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Mechanisms of agonist action at D2 dopamine receptors

4 September 2018

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Synergistic contributions of the functional groups of epinephrine to its affinity and efficacy at the beta2 adrenergic receptor.

4 September 2018

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Mechanisms of inverse agonism of antipsychotic drugs at the D(2) dopamine receptor: use of a mutant D(2) dopamine receptor that adopts the activated conformation

4 September 2018

1 reference

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The role of charge interactions in muscarinic agonist binding, and receptor-response coupling.

4 September 2018

1 reference

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Agonist Action at D2(short) Dopamine Receptors Determined in Ligand Binding and Functional Assays

4 September 2018

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12 December 2020

Three-state and two-state models

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12 December 2020

An aspartate conserved among G-protein receptors confers allosteric regulation of alpha 2-adrenergic receptors by sodium

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12 December 2020

Regulation of dopamine D2 receptors by sodium and pH

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12 December 2020

Alanine-scanning mutagenesis of transmembrane domain 6 of the M(1) muscarinic acetylcholine receptor suggests that Tyr381 plays key roles in receptor function

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12 December 2020

Scanning mutagenesis of transmembrane domain 3 of the M1 muscarinic acetylcholine receptor

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12 December 2020

Pivotal role of an aspartate residue in sodium sensitivity and coupling to G proteins of neurotensin receptors

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12 December 2020

Stimulus amplification, efficacy, and the operational model. Part I--binary complex occupancy mechanisms

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12 December 2020

Stimulus amplification, efficacy, and the operational model. Part II--ternary complex occupancy mechanisms

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12 December 2020

Interaction at End-Plate Receptors between Different Choline Derivatives

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12 December 2020

Conserved aspartic acid residues 79 and 113 of the beta-adrenergic receptor have different roles in receptor function

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12 December 2020

Continuous variation of agonist affinity constants

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12 December 2020

Mutation of an aspartate at residue 89 in somatostatin receptor subtype 2 prevents Na regulation of agonist binding but does not alter receptor-G protein association

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12 December 2020

Identifiers

DOI

10.1038/SJ.BJP.0707672

1 reference

18 August 2017

1 reference

PMC publication ID

2437915

18 August 2017

PubMed publication ID

18223670

1 reference

PMC publication ID

2437915