A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine. (Q37029832)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26962875 AND SRC:MED&resulttype=core&format=json

10 March 2020

title

A Perspective on Implementing a Quantitative Systems Pharmacology Platform for Drug Discovery and the Advancement of Personalized Medicine (English)

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10 March 2020

1 reference

personalized medicine

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1

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10 March 2020

Mark E Schurdak

2

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10 March 2020

Jeremy M. Berg

4

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10 March 2020

D. L. Taylor

5

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10 March 2020

author name string

Ivet Bahar

3

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10 March 2020

publication date

8 March 2016

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Journal of Biomolecular Screening

10 March 2020

published in

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10 March 2020

volume

21

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10 March 2020

issue

6

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10 March 2020

page(s)

521-534

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Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition.

10 March 2020

cites work

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Implementation of quantitative and systems pharmacology in large pharma

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Angiotensin receptor blockers: a panacea for Marfan syndrome and related disorders?

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Three-dimensional organotypic culture: experimental models of mammalian biology and disease

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RNAi screening comes of age: improved techniques and complementary approaches

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Single-cell genetic analysis reveals insights into clonal development of prostate cancers and indicates loss of PTEN as a marker of poor prognosis.

29 September 2017

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Systematic analysis of transcription-level effects of neurodegenerative diseases on human brain metabolism by a newly reconstructed brain-specific metabolic network

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Biological insights from 108 schizophrenia-associated genetic loci

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Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery

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Phenotypic screening in cancer drug discovery - past, present and future

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Mechanisms of CFTR functional variants that impair regulated bicarbonate permeation and increase risk for pancreatitis but not for cystic fibrosis

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29 September 2017

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Advances in IBD genetics

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A large scale Huntingtin protein interaction network implicates Rho GTPase signaling pathways in Huntington disease

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Discovery and saturation analysis of cancer genes across 21 tumour types

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Addressing genetic tumor heterogeneity through computationally predictive combination therapy

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Genotype to phenotype via network analysis

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Comprehensive identification of mutational cancer driver genes across 12 tumor types

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A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.

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A Nondegenerate Code of Deleterious Variants in Mendelian Loci Contributes to Complex Disease Risk

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Distilling pathophysiology from complex disease genetics

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Network-based approaches in drug discovery and early development

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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A twin approach to unraveling epigenetics

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Network medicine: a network-based approach to human disease

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Combined bicarbonate conductance-impairing variants in CFTR and SPINK1 variants are associated with chronic pancreatitis in patients without cystic fibrosis

29 September 2017

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Identification of optimal drug combinations targeting cellular networks: integrating phospho-proteomics and computational network analysis

29 September 2017

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Dissecting variability in responses to cancer chemotherapy through systems pharmacology

29 September 2017

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Cellular heterogeneity: do differences make a difference?

29 September 2017

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Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities

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Networks inferred from biochemical data reveal profound differences in toll-like receptor and inflammatory signaling between normal and transformed hepatocytes

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How to improve R&D productivity: the pharmaceutical industry's grand challenge

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Non-genetic heterogeneity of cells in development: more than just noise

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

Predicting new molecular targets for known drugs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

Rule-based modeling of biochemical systems with BioNetGen

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

Identifying the proteins to which small-molecule probes and drugs bind in cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

Network pharmacology: the next paradigm in drug discovery

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

Angiotensin II blockade and aortic-root dilation in Marfan's syndrome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

Quantitative analysis of pathways controlling extrinsic apoptosis in single cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

Network analysis of FDA approved drugs and their targets

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

Genetic Control of Biochemical Reactions in Neurospora

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

Advances in high content screening for drug discovery

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

High content screening applied to large-scale cell biology

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

A new approach to decoding life: systems biology

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

Characterization and quantitation of NF-kappaB nuclear translocation induced by interleukin-1 and tumor necrosis factor-alpha. Development and use of a high capacity fluorescence cytometric system.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

29 September 2017

2014 FDA drug approvals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

Long-term safety and efficacy of ivacaftor in patients with cystic fibrosis who have the Gly551Asp-CFTR mutation: a phase 3, open-label extension study (PERSIST).

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

Predicting drug-target interactions using probabilistic matrix factorization

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

Microfluidic organs-on-chips

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

The discovery of first-in-class drugs: origins and evolution.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

The contribution of mechanistic understanding to phenotypic screening for first-in-class medicines

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

Evaluating tumor heterogeneity in immunohistochemistry-stained breast cancer tissue

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

Predictive, personalized, preventive, participatory (P4) cancer medicine.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

Systems biology and pharmacology

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4917453

The relevance and potential roles of microphysiological systems in biology and medicine

4 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1177/1087057116635818

Galpha(q) and phospholipase C-beta: turn on, turn off, and do it fast.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1177/1087057116635818

Relevance of systems pharmacology in drug discovery

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26962875

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1177/1087057116635818

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26962875 AND SRC:MED&resulttype=core&format=json

10 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26962875 AND SRC:MED&resulttype=core&format=json

10 March 2020

PubMed publication ID

26962875

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26962875 AND SRC:MED&resulttype=core&format=json