Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2. (Q37011615)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15024084 AND SRC:MED&resulttype=core&format=json

25 December 2019

title

Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2 (English)

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25 December 2019

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3

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25 December 2019

author name string

Harry A Rogoff

1

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25 December 2019

Mary T Pickering

2

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25 December 2019

Michelle E Debatis

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25 December 2019

Yolanda Sanchez

5

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25 December 2019

Stephen Jones

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25 December 2019

Timothy F Kowalik

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language of work or name

English

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publication date

1 April 2004

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Molecular and Cellular Biology

25 December 2019

published in

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25 December 2019

volume

24

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25 December 2019

issue

7

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25 December 2019

page(s)

2968-2977

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Chk2 activates E2F-1 in response to DNA damage

25 December 2019

cites work

1 reference

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

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Direct coupling of the cell cycle and cell death machinery by E2F.

29 September 2017

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Checkpoint kinase 2 (Chk2) monomers or dimers phosphorylate Cdc25C after DNA damage regardless of threonine 68 phosphorylation

29 September 2017

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Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

29 September 2017

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E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis

29 September 2017

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Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response

29 September 2017

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Gene expression changes in response to E2F1 activation.

29 September 2017

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Identification of novel E2F1-regulated genes by microarray

29 September 2017

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ARF differentially modulates apoptosis induced by E2F1 and Myc.

29 September 2017

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E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints

29 September 2017

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p19(ARF) is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo

29 September 2017

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Use of chromatin immunoprecipitation to clone novel E2F target promoters

29 September 2017

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Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway

29 September 2017

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Cell cycle checkpoint signaling through the ATM and ATR kinases

29 September 2017

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Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation

29 September 2017

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Chk2 activation dependence on Nbs1 after DNA damage

29 September 2017

1 reference

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Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis

29 September 2017

1 reference

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29 September 2017

E2F-1 induced apoptosis

1 reference

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Post-translational modifications and activation of p53 by genotoxic stresses

29 September 2017

1 reference

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Expression analysis using DNA microarrays demonstrates that E2F-1 up-regulates expression of DNA replication genes including replication protein A2.

29 September 2017

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The many substrates and functions of ATM

29 September 2017

1 reference

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ATM and ATR: networking cellular responses to DNA damage

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis.

29 September 2017

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29 September 2017

1 reference

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Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

The Rb/E2F pathway: expanding roles and emerging paradigms

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

29 September 2017

1 reference

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Role of human cytomegalovirus immediate-early proteins in cell growth control

29 September 2017

1 reference

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Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

29 September 2017

1 reference

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Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

The E2F transcription factors: key regulators of cell proliferation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Substrate specificities and identification of putative substrates of ATM kinase family members

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

29 September 2017

1 reference

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Atm is dispensable for p53 apoptosis and tumor suppression triggered by cell cycle dysfunction

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Increased levels of E2F-1-dependent DNA binding activity after UV- or gamma-irradiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

The complexity of p53 modulation: emerging patterns from divergent signals

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Enhanced phosphorylation of p53 by ATM in response to DNA damage

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

A simplified system for generating recombinant adenoviruses

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

DNA damage induces phosphorylation of the amino terminus of p53

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Distinct roles for E2F proteins in cell growth control and apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Mdm2 promotes the rapid degradation of p53

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

p53 and E2F-1 cooperate to mediate apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Mediation of c-Myc-induced apoptosis by p53.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Mdm2 association with p53 targets its ubiquitination

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

p14ARF links the tumour suppressors RB and p53.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Human papillomavirus type 16 E7 regulates E2F and contributes to mitogenic signalling

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

The human papillomavirus type 16 E6 and E7 oncoproteins independently induce numerical and structural chromosome instability.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

p53-independent increase in E2F-1 expression enhances the cytotoxic effects of etoposide and of adriamycin

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=371110

Role for E2F in DNA damage-induced entry of cells into S phase

4 September 2018

1 reference

12 December 2020

Toward an understanding of the functional complexity of the E2F and retinoblastoma families

1 reference

12 December 2020

Signaling to p53: breaking the MDM2-p53 circuit

1 reference

12 December 2020

Stress signals induce transcriptionally inactive E2F-1 independently of p53 and Rb

1 reference

12 December 2020

ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation

1 reference

12 December 2020

Myc requires distinct E2F activities to induce S phase and apoptosis

1 reference

12 December 2020

The p53 functional circuit

1 reference

12 December 2020

ARF is not required for apoptosis in Rb mutant mouse embryos

1 reference

12 December 2020

10.1128/MCB.24.7.2968-2977.2004

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15024084 AND SRC:MED&resulttype=core&format=json

25 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15024084 AND SRC:MED&resulttype=core&format=json

25 December 2019

PubMed publication ID

15024084

1 reference