In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant. (Q37001755)

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1 April 2020

title

In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant (English)

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1 April 2020

0 references

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Lakshmi Ganapathi

2

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1 April 2020

Ilana Bergelson

3

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1 April 2020

David J Dowling

4

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1 April 2020

Michaela Banks

5

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Ronald C Samuels

6

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Jason D Marshall

8

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Ofer Levy

9

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publication date

12 April 2016

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volume

83

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page(s)

99-109

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The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes.

1 April 2020

cites work

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Identification of the key differential transcriptional responses of human whole blood following TLR2 or TLR4 ligation in-vitro

29 September 2017

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29 September 2017

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29 September 2017

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MyD88 and TRIF synergistic interaction is required for TH1-cell polarization with a synthetic TLR4 agonist adjuvant

29 September 2017

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The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes.

29 September 2017

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Neonatal plasmacytoid dendritic cells (pDCs) display subset variation but can elicit potent anti-viral innate responses

29 September 2017

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Molecular and cellular response profiles induced by the TLR4 agonist-based adjuvant Glucopyranosyl Lipid A

29 September 2017

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Innate immune function by Toll-like receptors: distinct responses in newborns and the elderly

29 September 2017

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Immune response to vaccine adjuvants during the first year of life

29 September 2017

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Ontogeny of Toll-like receptor mediated cytokine responses of South African infants throughout the first year of life.

29 September 2017

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Alum increases antigen uptake, reduces antigen degradation and sustains antigen presentation by DCs in vitro

29 September 2017

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Use of human MonoMac6 cells for development of in vitro assay predictive of adjuvant safety in vivo

29 September 2017

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Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways

29 September 2017

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Small cationic DDA:TDB liposomes as protein vaccine adjuvants obviate the need for TLR agonists in inducing cellular and humoral responses

29 September 2017

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Neonatal plasma polarizes TLR4-mediated cytokine responses towards low IL-12p70 and high IL-10 production via distinct factors

29 September 2017

1 reference

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Regulation of immune responses by prostaglandin E2

29 September 2017

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Development of Newborn and Infant Vaccines

29 September 2017

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Evaluation of the safety and immunogenicity in rhesus monkeys of a recombinant malaria vaccine for Plasmodium vivax with a synthetic Toll-like receptor 4 agonist formulated in an emulsion

29 September 2017

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Age-dependent maturation of Toll-like receptor-mediated cytokine responses in Gambian infants

29 September 2017

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Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells

29 September 2017

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Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases.

29 September 2017

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Development and characterization of synthetic glucopyranosyl lipid adjuvant system as a vaccine adjuvant

29 September 2017

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Use of defined TLR ligands as adjuvants within human vaccines.

29 September 2017

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Vaccine Adjuvants: Putting Innate Immunity to Work

29 September 2017

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PGE(2) transiently enhances DC expression of CCR7 but inhibits the ability of DCs to produce CCL19 and attract naive T cells

29 September 2017

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Acquisition of adult-like TLR4 and TLR9 responses during the first year of life

29 September 2017

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TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremia

29 September 2017

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Neonatal innate TLR-mediated responses are distinct from those of adults.

29 September 2017

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Neonatal immunity: faulty T-helpers and the shortcomings of dendritic cells

29 September 2017

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Phenotype and function of neonatal DC.

29 September 2017

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Molecular and cellular signatures of human vaccine adjuvants.

29 September 2017

1 reference

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Consent for neonatal research

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4906944

Innate immunity of the human newborn is polarized toward a high ratio of IL-6/TNF-alpha production in vitro and in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4906944

The adenosine system selectively inhibits TLR-mediated TNF-alpha production in the human newborn.

29 September 2017

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The beta-glucan receptor dectin-1 functions together with TLR2 to mediate macrophage activation by mycobacteria

29 September 2017

1 reference

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Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4906944

Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates

29 September 2017

1 reference

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Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4906944

HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8 T cell responses in nonhuman primates

29 September 2017

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Innate immunity of the human newborn: distinct cytokine responses to LPS and other Toll-like receptor agonists

29 September 2017

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Functionally mature virus-specific CD8( ) T memory cells in congenitally infected newborns: proof of principle for neonatal vaccination?

29 September 2017

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Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells

29 September 2017

1 reference

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Safety and immunogenicity of heptavalent pneumococcal CRM197 conjugate vaccine in infants and toddlers

29 September 2017

1 reference

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MF59 Mediates Its B Cell Adjuvanticity by Promoting T Follicular Helper Cells and Thus Germinal Center Responses in Adult and Early Life.

29 September 2017

1 reference

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Dectin-1 activation unlocks IL12A expression and reveals the TH1 potency of neonatal dendritic cells

29 September 2017

1 reference

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Vaccination with the RSV fusion protein formulated with a combination adjuvant induces long-lasting protective immunity.

29 September 2017

1 reference

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TLR4 ligand formulation causes distinct effects on antigen-specific cell-mediated and humoral immune responses

27 June 2018

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The TLR3/TICAM-1 Pathway Is Mandatory for Innate Immune Responses to Poliovirus Infection

27 June 2018

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Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848.

27 June 2018

1 reference

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Predictive markers of safety and immunogenicity of adjuvanted vaccines

27 June 2018

1 reference

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Age-matched dendritic cell subpopulations reference values in childhood.

4 September 2018

1 reference

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The vaccine adjuvant alum inhibits IL-12 by promoting PI3 kinase signaling while chitosan does not inhibit IL-12 and enhances Th1 and Th17 responses.

4 September 2018

1 reference

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Enumeration of human peripheral blood dendritic cells throughout the life

4 September 2018

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Reference values for B cell subpopulations from infancy to adulthood

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4906944

Neonatal cord blood subsets and cytokine response to bacterial antigens

4 September 2018

1 reference

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Interferon regulatory factor 7-mediated responses are defective in cord blood plasmacytoid dendritic cells

4 September 2018

1 reference

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The 23-valent pneumococcal polysaccharide vaccine does not provide additional serotype antibody protection in children who have been primed with two doses of heptavalent pneumococcal conjugate vaccine

4 December 2018

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Blood plasmacytoid dendritic cell responses to CpG oligodeoxynucleotides are impaired in human newborns

4 December 2018

1 reference

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TLR2 and TLR4 serve distinct roles in the host immune response against Mycobacterium bovis BCG

4 December 2018

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12 December 2020

The ratio between dendritic cells and T cells determines whether prostaglandin E2 has a stimulatory or inhibitory effect

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12 December 2020

Endotoxin-stimulated production of IL-6 and IL-8 is increased in short-term cultures of whole blood from healthy term neonates

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12 December 2020

Dendritic cells matured by a prostaglandin E2-containing cocktail can produce high levels of IL-12p70 and are more mature and Th1-biased than dendritic cells treated with TNF-α or LPS

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12 December 2020

MF59 and Pam3CSK4 Boost Adaptive Responses to Influenza Subunit Vaccine through an IFN Type I-Independent Mechanism of Action

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12 December 2020

10.1016/J.CYTO.2016.04.001

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27081760 AND SRC:MED&resulttype=core&format=json

1 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27081760 AND SRC:MED&resulttype=core&format=json

1 April 2020

PubMed publication ID

27081760

1 reference