Use of okadaic acid to identify relevant phosphoepitopes in pathology: a focus on neurodegeneration (Q36999161)

17 August 2017

1 reference

10 January 2024

Use of okadaic acid to identify relevant phosphoepitopes in pathology: a focus on neurodegeneration (English)

1 reference

17 August 2017

1 reference

25 April 2019

1 reference

8 November 2019

1 reference

PubMed publication ID

3

Nieves Villanueva

1 reference

17 August 2017

2

Jesús Avila

1 reference

17 August 2017

1

Miguel Medina

1 reference

17 August 2017

21 May 2013

4 references

17 August 2017

25 April 2019

8 November 2019

10 January 2024

4 references

17 August 2017

25 April 2019

8 November 2019

10 January 2024

11

1 reference

17 August 2017

5

1 reference

17 August 2017

1656-1668

1 reference

Creative Commons Attribution 3.0 Unported

17 August 2017

3 references

25 April 2019

8 November 2019

on focus list of Wikimedia project

10 January 2024

copyright status

copyrighted

0 references

ScienceSource

0 references

cites work

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29 September 2017

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Effects of PTEN inhibition on regulation of tau phosphorylation in an okadaic acid-induced neurodegeneration model

29 September 2017

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Toxin levels and profiles in microalgae from the north-Western Adriatic Sea--15 years of studies on cultured species

29 September 2017

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Identification of differentially expressed genes in SHSY5Y cells exposed to okadaic acid by suppression subtractive hybridization.

29 September 2017

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Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by α7 and β2* nicotinic stimulation

29 September 2017

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Novel screening cascade identifies MKK4 as key kinase regulating Tau phosphorylation at Ser422.

29 September 2017

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Recent Developments in Tau-Based Therapeutics for Neurodegenerative Diseases

29 September 2017

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Intracellular and extracellular tau.

29 September 2017

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A novel organotypic tauopathy model on a new microcavity chip for bioelectronic label-free and real time monitoring

29 September 2017

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Targets and effects of yessotoxin, okadaic acid and palytoxin: a differential review

29 September 2017

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Peptidyl-prolyl isomerase 1 regulates protein phosphatase 2A-mediated topographic phosphorylation of neurofilament proteins

29 September 2017

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Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

29 September 2017

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Carcinogenic aspects of protein phosphatase 1 and 2A inhibitors

29 September 2017

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Mechanisms of tau-induced neurodegeneration

29 September 2017

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Marine toxins and the cytoskeleton: okadaic acid and dinophysistoxins.

29 September 2017

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Phosphorylated tau: toxic, protective, or none of the above

29 September 2017

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Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A.

29 September 2017

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29 September 2017

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Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse

29 September 2017

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Regulation of cell adhesion by PP2A and SV40 small tumor antigen: an important link to cell transformation

29 September 2017

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Determination of phosphorylated residues from human respiratory syncytial virus P protein that are dynamically dephosphorylated by cellular phosphatases: a possible role for serine 54.

29 September 2017

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Protein phosphatase inhibition: structure based design. Towards new therapeutic agents

29 September 2017

1 reference

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Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Alzheimer's disease is a synaptic failure

29 September 2017

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Okadaic acid: the archetypal serine/threonine protein phosphatase inhibitor

29 September 2017

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Okadaic acid, useful tool for studying cellular processes

29 September 2017

1 reference

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Characterization of distinct apoptotic changes induced by okadaic acid and yessotoxin in the BE(2)-M17 neuroblastoma cell line

29 September 2017

1 reference

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Regulated but not constitutive human respiratory syncytial virus (HRSV) P protein phosphorylation is essential for oligomerization

29 September 2017

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Neurotoxic and synaptic effects of okadaic acid, an inhibitor of protein phosphatases

29 September 2017

1 reference

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Induction of a specific tau Alzheimer epitope in SY-5Y neuroblastoma cells.

29 September 2017

1 reference

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Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau

29 September 2017

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Protein kinases involved in the phosphorylation of human tau protein in transfected COS-1 cells.

29 September 2017

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Hyperphosphorylation of tau in PHF

29 September 2017

2 references

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29 September 2017

https://api.crossref.org/works/10.3390/MD11051656

Functional implications for the microtubule-associated protein tau: localization in oligodendrocytes

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

The microtubule binding domain of tau protein.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Okadaic acid: a new probe for the study of cellular regulation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Classification of protein-serine/threonine phosphatases: identification and quantitation in cell extracts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

The role of tau phosphorylation in transfected COS-1 cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Tau Phosphorylation by GSK3 in Different Conditions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: implication in Alzheimer's disease pathogenesis.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

The protein phosphatase inhibitor okadaic acid induces heat shock protein expression and neurodegeneration in rat hippocampus in vivo

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

The in vitro formation of recombinant tau polymers: effect of phosphorylation and glycation.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

The phosphorylation of tau: a critical stage in neurodevelopment and neurodegenerative processes.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

In vivo phosphorylation in the rat basal nucleus induces PHF-like and APP immunoreactivity

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Injury and recovery process of intestine caused by okadaic acid and related compounds

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Toxic mussels and okadaic acid induce rapid hypersecretion in the rat small intestine.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Apparent "activation" of protein kinases by okadaic acid class tumor promoters

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

The tumor promoters 12-O-tetradecanoylphorbol-13-acetate and okadaic acid differ in toxicity, mitogenic activity and induction of gene expression

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

The marine toxin okadaic acid is a potent neurotoxin for cultured cerebellar neurons

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Site-specific serine phosphorylation of spinach leaf sucrose-phosphate synthase

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Okadaic acid induced neurotoxicity leads to central cholinergic dysfunction in rats.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Neuroglial alterations in rats submitted to the okadaic acid-induced model of dementia.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Co-pathological connected primary neurons in a microfluidic device for Alzheimer studies.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

An okadaic acid-induced model of tauopathy and cognitive deficiency.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Activation of eukaryotic initiation factor-2 α-kinases in okadaic acid-treated neurons

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

The total activity of a mixture of okadaic acid-group compounds can be calculated by those of individual analogues in a phosphoprotein phosphatase 2A assay

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Phosphorylation of human respiratory syncytial virus P protein at serine 54 regulates viral uncoating

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Phosphorylation of human respiratory syncytial virus P protein at threonine 108 controls its interaction with the M2-1 protein in the viral RNA polymerase complex

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

BACE inhibitor reduces APP-beta-C-terminal fragment accumulation in axonal swellings of okadaic acid-induced neurodegeneration

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Swiss mice CD1 fed on mussels contaminated by okadaic acid and yessotoxins: effects on thymus and spleen

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Okadaic acid mediates tau phosphorylation via sustained activation of the L-voltage-sensitive calcium channel

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Spatial memory deficit and neurodegeneration induced by the direct injection of okadaic acid into the hippocampus in rats

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Investigation of the distribution and excretion of okadaic acid in mice using immunostaining method

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Effects of the diarrhetic shellfish toxin, okadaic acid, on cytoskeletal elements, viability and functionality of rat liver and intestinal cells

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Phosphorylation of Tau, Aβ-Formation, and Apoptosis After In Vivo Inhibition of PP-1 and PP-2A

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Phosphatase inhibition in human neuroblastoma cells alters tau antigenicity and renders it incompetent to associate with exogenous microtubules

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707166

Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria

4 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.3390/MD11051656

Diarrhetic shellfish toxins

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.3390/MD11051656

Tau phosphorylation and neuronal apoptosis induced by the blockade of PP2A preferentially involve GSK3β

21 January 2018

1 reference

12 December 2020

Injections of okadaic acid, but not beta-amyloid peptide, induce Alz-50 immunoreactive dystrophic neurites in the cerebral cortex of sheep

1 reference

12 December 2020

Identification of okadaic acid from a Caribbean dinoflagellate, Prorocentrum concavum

1 reference

12 December 2020

zVLL-CHO at low concentrations acts as a calpain inhibitor to protect neurons against okadaic acid-induced neurodegeneration

1 reference

12 December 2020

Identifiers

DOI

10.3390/MD11051656

1 reference

17 August 2017

1 reference

PMC publication ID

3707166

17 August 2017

PubMed publication ID

23697949

1 reference

PMC publication ID

3707166