Forced involution of the functionally differentiated mammary gland by overexpression of the pro-apoptotic protein bax (Q36989962)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21254334 AND SRC:MED&resulttype=core&format=json

20 January 2020

title

Forced involution of the functionally differentiated mammary gland by overexpression of the pro-apoptotic protein bax (English)

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20 January 2020

1 reference

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5

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20 January 2020

author name string

Edmund B Rucker

1

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20 January 2020

Amber N Hale

2

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20 January 2020

David C Durtschi

3

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20 January 2020

Kazuhito Sakamoto

4

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20 January 2020

language of work or name

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3 January 2011

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20 January 2020

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20 January 2020

volume

49

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20 January 2020

issue

1

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20 January 2020

page(s)

24-35

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Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1.

20 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Mammary gland involution as a multi-step process

9 September 2017

1 reference

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The beginning of the end: death signaling in early involution

9 September 2017

1 reference

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c-myc as a mediator of accelerated apoptosis and involution in mammary glands lacking Socs3.

9 September 2017

1 reference

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Information networks in the mammary gland.

9 September 2017

1 reference

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Apoptosis regulation in the mammary gland

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression

9 September 2017

1 reference

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Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3

9 September 2017

1 reference

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In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

9 September 2017

1 reference

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The pro-apoptotic gene Bax is required for the death of ectopic primordial germ cells during their migration in the mouse embryo

9 September 2017

1 reference

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PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Haploid loss of bax leads to accelerated mammary tumor development in C3(1)/SV40-TAg transgenic mice: reduction in protective apoptotic response at the preneoplastic stage

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

The Bcl-2 protein family: arbiters of cell survival

9 September 2017

1 reference

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9 September 2017

Caspases: enemies within

1 reference

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Death receptors: signaling and modulation

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

BCL-2 FAMILY: Regulators of Cell Death

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Modulation of cell death by Bcl-x L through caspase interaction

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Human ICE/CED-3 protease nomenclature

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Bax and Bcl-xs are induced at the onset of apoptosis in involuting mammary epithelial cells

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Glucocorticoid and progesterone inhibit involution and programmed cell death in the mouse mammary gland

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

PUMA- and Bax-induced autophagy contributes to apoptosis

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Conversion of Bcl-2 to a Bax-like Death Effector by Caspases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Modulation of clusterin gene expression in the rat mammary gland during pregnancy, lactation, and involution

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Differential activation of STATs 3 and 5 during mammary gland development

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Do inducers of apoptosis trigger caspase-independent cell death?

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Insulin-like growth factor binding protein-5 (IGFBP-5) induces premature cell death in the mammary glands of transgenic mice

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Conditional deletion of the bcl-x gene from mouse mammary epithelium results in accelerated apoptosis during involution but does not compromise cell function during lactation.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Mammary gland involution is delayed by activated Akt in transgenic mice.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Fragmentation and death (a.k.a. apoptosis) of ovulated oocytes

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3703757

Protein kinase A and AP-1 (c-Fos/JunD) are induced during apoptosis of mouse mammary epithelial cells

4 September 2018

1 reference

12 December 2020

Overexpression of an Agouti cDNA in the skin of transgenic mice recapitulates dominant coat color phenotypes of spontaneous mutants

1 reference

12 December 2020

1 reference

12 December 2020

Death domain receptors and their role in cell demise

1 reference

12 December 2020

Loss of anti-mitotic effects of Bcl-2 with retention of anti-apoptotic activity during tumor progression in a mouse model

1 reference

12 December 2020

Inhibition of mammary epithelial apoptosis and sustained phosphorylation of Akt/PKB in MMTV-IGF-II transgenic mice

1 reference

12 December 2020

Delayed mammary gland involution in MMTV-AKT1 transgenic mice

1 reference

12 December 2020

Overexpression and forced activation of stat5 in mammary gland of transgenic mice promotes cellular proliferation, enhances differentiation, and delays postlactational apoptosis

1 reference

12 December 2020

Identifiers

DOI

10.1002/DVG.20691

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21254334 AND SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21254334 AND SRC:MED&resulttype=core&format=json

20 January 2020

PubMed publication ID

21254334

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21254334 AND SRC:MED&resulttype=core&format=json