Big wheel keeps on turning: apoptosome regulation and its role in chemoresistance (Q36988138)

17 August 2017

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title

Big wheel keeps on turning: apoptosome regulation and its role in chemoresistance (English)

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17 August 2017

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Fadeel B

1

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17 August 2017

Ottosson A

series ordinal

2

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17 August 2017

Pervaiz S

series ordinal

3

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17 August 2017

publication date

2 November 2007

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Cell Death & Differentiation

17 August 2017

published in

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17 August 2017

volume

15

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17 August 2017

issue

3

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17 August 2017

page(s)

443-452

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Programmed cell death in animal development

17 August 2017

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Caspase Activity and a Specific Cytochrome C Are Required for Sperm Differentiation in Drosophila

21 January 2018

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Cytochrome c-d regulates developmental apoptosis in the Drosophila retina

21 January 2018

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Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development

21 January 2018

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Apaf1 is required for mitochondrial pathways of apoptosis and brain development

21 January 2018

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Apaf-1 deficiency and neural tube closure defects are found in fog mice

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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A morphologically conserved nonapoptotic program promotes linker cell death in Caenorhabditis elegans

21 January 2018

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21 January 2018

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Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis

21 January 2018

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The apoptosome pathway to caspase activation in primary human neutrophils exhibits dramatically reduced requirements for cytochrome C

21 January 2018

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21 January 2018

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21 January 2018

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Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome C and inhibiting apoptosome

21 January 2018

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Physiological concentrations of K inhibit cytochrome c-dependent formation of the apoptosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402265

Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration

21 January 2018

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Regulation of cell death: the calcium-apoptosis link

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402265

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21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402265

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402265

Negative regulation of the Apaf-1 apoptosome by Hsp70

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4402265

Heat-shock protein 70 antagonizes apoptosis-inducing factor

21 January 2018

1 reference

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Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90

21 January 2018

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Hsp27 negatively regulates cell death by interacting with cytochrome c.

21 January 2018

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Hsp27 functions as a negative regulator of cytochrome c-dependent activation of procaspase-3.

21 January 2018

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Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance

21 January 2018

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Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway

21 January 2018

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Overexpression of the oncoprotein prothymosin alpha triggers a p53 response that involves p53 acetylation

21 January 2018

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Enhanced sensitivity to cytochrome c-induced apoptosis mediated by PHAPI in breast cancer cells

21 January 2018

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Control of apoptosis by p53.

21 January 2018

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Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

21 January 2018

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Apaf-1 is a transcriptional target for E2F and p53

21 January 2018

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Apaf-1 is a mediator of E2F-1-induced apoptosis

21 January 2018

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Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation.

21 January 2018

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Inactivation of the apoptosis effector Apaf-1 in malignant melanoma

21 January 2018

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Apoptosis protease activator protein-1 expression is dispensable for response of human melanoma cells to distinct proapoptotic agents

21 January 2018

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Role of DNA methylation in the suppression of Apaf-1 protein in human leukaemia

21 January 2018

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Silencing of APAF-1 in B-CLL results in poor prognosis in the case of concomitant p53 mutation

21 January 2018

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Methylation silencing of the Apaf-1 gene in acute leukemia

21 January 2018

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Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activity

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.CDD.4402265

Increased expression of Apaf-1 and procaspase-3 and the functionality of intrinsic apoptosis apparatus in non-small cell lung carcinoma

21 January 2018

1 reference

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Positive regulation of apoptosis by HCA66, a new Apaf-1 interacting protein, and its putative role in the physiopathology of NF1 microdeletion syndrome patients

21 January 2018

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Reawakening the cellular death program in neoplasia through the therapeutic blockade of IAP function

21 January 2018

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A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma

21 January 2018

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Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo

21 January 2018

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Drug insight: cancer therapy strategies based on restoration of endogenous cell death mechanisms

21 January 2018

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Induction of endogenous Bcl-xS through the control of Bcl-x pre-mRNA splicing by antisense oligonucleotides

21 January 2018

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Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

21 January 2018

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

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Direct activation of the apoptosis machinery as a mechanism to target cancer cells

21 January 2018

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21 January 2018

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21 January 2018

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Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis

21 January 2018

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Apoptosis-based therapies and drug targets

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.CDD.4402265

Human skeletal muscle cytosols are refractory to cytochrome c-dependent activation of type-II caspases and lack APAF-1

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.CDD.4402265

7 January 2021

Expression and functional analysis of Apaf-1 isoforms. Extra Wd-40 repeat is required for cytochrome c binding and regulated activation of procaspase-9

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https://api.crossref.org/works/10.1038/SJ.CDD.4402265

7 January 2021

Nuclear localization of apoptosis protease activating factor-1 predicts survival after tumor resection in early-stage non-small cell lung cancer

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7 January 2021

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

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7 January 2021

Calcium blocks formation of apoptosome by preventing nucleotide exchange in Apaf-1

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https://api.crossref.org/works/10.1038/SJ.CDD.4402265

7 January 2021

Reduced Apaf-1 expression in human cutaneous melanomas

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7 January 2021

Lack of apoptotic protease activating factor-1 expression and resistance to hypoxia-induced apoptosis in cervical cancer

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7 January 2021

Loss of APAF-1 expression is associated with tumour progression and adverse prognosis in colorectal cancer

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7 January 2021

All along the watchtower: on the regulation of apoptosis regulators.

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7 January 2021

Smac-mediated sensitization of human B-lymphoma cells to staurosporine- and lactacystin-triggered apoptosis is apoptosome-dependent

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7 January 2021

BCL-2 antisense therapy in patients with non-Hodgkin lymphoma

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7 January 2021

p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target

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7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4402265

1 reference

17 August 2017

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