Involvement of alpha(v)beta3 integrins in osteoclast function (Q36984939)

17 August 2017

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title

Involvement of alpha(v)beta3 integrins in osteoclast function (English)

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17 August 2017

Ichiro Nakamura

1

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17 August 2017

Le T Duong

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2

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17 August 2017

Sevgi B Rodan

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3

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17 August 2017

Gideon A Rodan

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4

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17 August 2017

publication date

25 October 2007

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Journal of Bone and Mineral Metabolism

17 August 2017

published in

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volume

25

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issue

6

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17 August 2017

page(s)

337-344

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Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases

17 August 2017

cites work

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Crossref

https://api.crossref.org/works/10.1007/S00774-007-0773-9

Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

21 January 2018

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Crossref

https://api.crossref.org/works/10.1007/S00774-007-0773-9

IL-1 regulates cytoskeletal organization in osteoclasts via TNF receptor-associated factor 6/c-Src complex

21 January 2018

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Crossref

https://api.crossref.org/works/10.1007/S00774-007-0773-9

An interleukin 1 like factor stimulates bone resorption in vitro.

21 January 2018

1 reference

12 December 2020

TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src

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12 December 2020

Osteoclasts express high levels of pp60c-src in association with intracellular membranes

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12 December 2020

The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor

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12 December 2020

Bone resorption by osteoclasts

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12 December 2020

c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption.

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12 December 2020

Role of alpha(v)beta(3) integrin in osteoclast migration and formation of the sealing zone.

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12 December 2020

Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture

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Inhibition of osteoclastic bone resorption in vivo by echistatin, an "arginyl-glycyl-aspartyl" (RGD)-containing protein

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12 December 2020

ArgGlyAsp (RGD) peptides and the anti-vitronectin receptor antibody 23C6 inhibit dentine resorption and cell spreading by osteoclasts*1

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12 December 2020

A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo

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12 December 2020

Tyrosine phosphorylation of p130Cas is involved in actin organization in osteoclasts.

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12 December 2020

Comparison of the bone-resorbing activity in the supernatants from phytohemagglutinin-stimulated human peripheral blood mononuclear cells with that of cytokines through the use of an antiserum to interleukin 1

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12 December 2020

Disease-modifying activity of SB 273005, an orally active, nonpeptide alphavbeta3 (vitronectin receptor) antagonist, in rat adjuvant-induced arthritis

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12 December 2020

Effect of L-000845704, an alphaVbeta3 integrin antagonist, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women

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12 December 2020

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

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12 December 2020

Histomorphometric Evidence for Echistatin Inhibition of Bone Resorption in Mice with Secondary Hyperparathyroidism

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12 December 2020

Monoclonal antibodies against osteoclasts inhibit bone resorption in vitro

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12 December 2020

Effects of interleukin-1 on bone turnover in normal mice

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12 December 2020

Distinct roles of p130Cas and c-Cbl in adhesion-induced or macrophage colony-stimulating factor-mediated signaling pathways in prefusion osteoclasts

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12 December 2020

Osteoclasts in normal and adjuvant arthritis bone tissues express the mRNA for both type I and II interleukin-1 receptors

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12 December 2020

Activation of NF-kappaB is involved in the survival of osteoclasts promoted by interleukin-1

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12 December 2020

Echistatin is a potent inhibitor of bone resorption in culture

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12 December 2020

Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

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12 December 2020

Integrins and signal transduction pathways: the road taken

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12 December 2020

Interleukin 1 induces multinucleation and bone-resorbing activity of osteoclasts in the absence of osteoblasts/stromal cells

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12 December 2020

Src family kinases are required for integrin but not PDGFR signal transduction.

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12 December 2020

A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration

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12 December 2020

Antibody to beta3 integrin inhibits osteoclast-mediated bone resorption in the thyroparathyroidectomized rat

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12 December 2020

Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins

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12 December 2020

The Integrin Ligand Echistatin Prevents Bone Loss in Ovariectomized Mice and Rats

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12 December 2020

c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism

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12 December 2020

Antagonism of the osteoclast vitronectin receptor with an orally active nonpeptide inhibitor prevents cancellous bone loss in the ovariectomized rat.

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12 December 2020

Stable association of PYK2 and p130(Cas) in osteoclasts and their co-localization in the sealing zone

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12 December 2020

Convergence of alpha(v)beta(3) integrin- and macrophage colony stimulating factor-mediated signals on phospholipase Cgamma in prefusion osteoclasts

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Localization and possible role of two different alpha v beta 3 integrin conformations in resting and resorbing osteoclasts.

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Regulatory mechanism of osteoclast activation

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12 December 2020

Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility

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12 December 2020

Integrin subunit β3 plays a crucial role in the movement of osteoclasts from the periosteum to the bone surface

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12 December 2020

Protein tyrosine kinase PYK2 involved in Ca(2 )-induced regulation of ion channel and MAP kinase functions

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12 December 2020

alpha vbeta 3 integrin associates with activated insulin and PDGFbeta receptors and potentiates the biological activity of PDGF

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12 December 2020

Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migration

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12 December 2020

Nonpeptide alpha(v)beta(3) antagonists. 1. Transformation of a potent, integrin-selective alpha(IIb)beta(3) antagonist into a potent alpha(v)beta(3) antagonist

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12 December 2020

Integrins: versatility, modulation, and signaling in cell adhesion

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12 December 2020

Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice

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12 December 2020

Integrin signalling and tyrosine phosphorylation: just the FAKs?

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12 December 2020

Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by beta3 integrin

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12 December 2020

Role of colony-stimulating factor-1 in bone metabolism

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12 December 2020

PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase

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12 December 2020

Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts

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12 December 2020

Echistatin inhibits the migration of murine prefusion osteoclasts and the formation of multinucleated osteoclast-like cells

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12 December 2020

The alpha v beta 3 integrin "vitronectin receptor"

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12 December 2020

10.1007/S00774-007-0773-9

Identifiers

DOI

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17 August 2017

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