The science of adjuvants (Q36968250)

17 August 2017

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title

The science of adjuvants (English)

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17 August 2017

3

Bali Pulendran

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17 August 2017

1

Marcin Kwissa

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17 August 2017

2

Sudhir Pai Kasturi

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17 August 2017

publication date

1 October 2007

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Expert Review of Vaccines

17 August 2017

published in

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17 August 2017

volume

6

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17 August 2017

issue

5

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17 August 2017

page(s)

673-684

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Vaccines in historic evolution and perspective: a narrative of vaccine discoveries

17 August 2017

cites work

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https://api.crossref.org/works/10.1586/14760584.6.5.673

Vaccine manufacturing: challenges and solutions

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Synthesis and assembly of hepatitis B virus surface antigen particles in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Self-defense: The fruit fly style

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Pathogen recognition and innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Toll-like receptor function and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

5'-Triphosphate RNA is the ligand for RIG-I

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Toll or toll-free adjuvant path toward the optimal vaccine development

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

NLRs join TLRs as innate sensors of pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Myeloid C-type lectins in innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

TLR signaling in the gut in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Distinct dendritic cell subsets differentially regulate the class of immune response in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

CD8( ) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Natural interferon alpha/beta-producing cells link innate and adaptive immunity

21 January 2018

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https://api.crossref.org/works/10.1586/14760584.6.5.673

Translating innate immunity into immunological memory: implications for vaccine development

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Role of Innate Immune Factors in the Adjuvant Activity of Monophosphoryl Lipid A

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

TLR11 activation of dendritic cells by a protozoan profilin-like protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Therapeutic potential of Toll-like receptor 9 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

CPG 7909 adjuvant improves hepatitis B virus vaccine seroprotection in antiretroviral-treated HIV-infected adults.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Testing of CpG-optimized protein and DNA vaccines against the hepatitis B virus in chimpanzees for immunogenicity and protection from challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Helicobacter pylori modulates the T helper cell 1/T helper cell 2 balance through phase-variable interaction between lipopolysaccharide and DC-SIGN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

DC-SIGN ligation on dendritic cells results in ERK and PI3K activation and modulates cytokine production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Intracellular pattern recognition receptors in the host response

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Nod-like proteins in immunity, inflammation and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Function of RIG-I-like receptors in antiviral innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Principles of intracellular viral recognition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Vaccinia virus protein A52R activates p38 mitogen-activated protein kinase and potentiates lipopolysaccharide-induced interleukin-10

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Mycobacteria target DC-SIGN to suppress dendritic cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guérin: involvement of toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Recent advances in the discovery and delivery of vaccine adjuvants

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Safety and immunogenicity of an enterotoxigenic Escherichia coli vaccine patch containing heat-labile toxin: use of skin pretreatment to disrupt the stratum corneum

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Transcutaneous immunization with the heat-labile toxin (LT) of enterotoxigenic Escherichia coli (ETEC): protective efficacy in a double-blind, placebo-controlled challenge study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

MF59-adjuvanted vaccines: increased immunogenicity with an optimal safety profile

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Dendritic cells internalize vaccine adjuvant after intramuscular injection

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Recent advances in vaccine adjuvants: the development of MF59 emulsion and polymeric microparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

TLR4 agonists as immunomodulatory agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Enhanced humoral and memory B cellular immunity using HPV16/18 L1 VLP vaccine formulated with the MPL/aluminium salt combination (AS04) compared to aluminium salt only

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Development of TLR9 agonists for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Antigen co-encapsulated with adjuvants efficiently drive protective T cell immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Targeting the innate immune response with improved vaccine adjuvants

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8 T cell responses in nonhuman primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Immunization with HIV-1 Gag protein conjugated to a TLR7/8 agonist results in the generation of HIV-1 Gag-specific Th1 and CD8 T cell responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Vaccination with recombinant fusion proteins incorporating Toll-like receptor ligands induces rapid cellular and humoral immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

A West Nile virus recombinant protein vaccine that coactivates innate and adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Priming of CD8 T-cell responses after DNA immunization is impaired in TLR9- and MyD88-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Toll-like receptor adaptor molecules enhance DNA-raised adaptive immune responses against influenza and tumors through activation of innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

CpG-modified plasmid DNA encoding flagellin improves immunogenicity and provides protection against Burkholderia pseudomallei infection in BALB/c mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Imiquimod and S-27609 as adjuvants of DNA vaccination in a transgenic murine model of HER2/neu-positive mammary carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Resiquimod is a modest adjuvant for HIV-1 gag-based genetic immunization in a mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Nod1-Mediated Innate Immune Recognition of Peptidoglycan Contributes to the Onset of Adaptive Immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

Control of B-cell responses by Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1586/14760584.6.5.673

21 January 2018

Identifiers

DOI

10.1586/14760584.6.5.673

1 reference

17 August 2017

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