Generic cell dysfunction in neurodegenerative disorders: role of surfaces in early protein misfolding, aggregation, and aggregate cytotoxicity. (Q36954090)

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scientific article published on October 2007

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English	Generic cell dysfunction in neurodegenerative disorders: role of surfaces in early protein misfolding, aggregation, and aggregate cytotoxicity.	scientific article published on October 2007

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17901260 AND SRC:MED&resulttype=core&format=json

8 January 2020

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Europe PubMed Central

Generic cell dysfunction in neurodegenerative disorders: role of surfaces in early protein misfolding, aggregation, and aggregate cytotoxicity (English)

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17901260 AND SRC:MED&resulttype=core&format=json

8 January 2020

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neurodegeneration

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based on heuristic

inferred from title

Massimo Stefani

1

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17901260 AND SRC:MED&resulttype=core&format=json

8 January 2020

author name string

Massimo Stefani

1

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Europe PubMed Central

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17 August 2017

publication date

1 October 2007

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17901260 AND SRC:MED&resulttype=core&format=json

8 January 2020

The Neuroscientist

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17901260 AND SRC:MED&resulttype=core&format=json

8 January 2020

13

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Europe PubMed Central

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8 January 2020

5

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Europe PubMed Central

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8 January 2020

519-531

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17901260 AND SRC:MED&resulttype=core&format=json

8 January 2020

Neuronal membrane cholesterol loss enhances amyloid peptide generation

1 reference

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21 January 2018

Gradual alteration of mitochondrial structure and function by beta-amyloids: importance of membrane viscosity changes, energy deprivation, reactive oxygen species production, and cytochrome c release

1 reference

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21 January 2018

Plasma membrane cholesterol controls the cytotoxicity of Alzheimer's disease AbetaP (1-40) and (1-42) peptides.

1 reference

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21 January 2018

Prefibrillar amyloid aggregates could be generic toxins in higher organisms.

1 reference

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21 January 2018

Neuronal differentiation of human mesenchymal stem cells: changes in the expression of the Alzheimer's disease-related gene seladin-1.

1 reference

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21 January 2018

Two types of Alzheimer's beta-amyloid (1-40) peptide membrane interactions: aggregation preventing transmembrane anchoring versus accelerated surface fibril formation.

1 reference

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21 January 2018

Nature disfavors sequences of alternating polar and non-polar amino acids: implications for amyloidogenesis

1 reference

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21 January 2018

Prefibrillar amyloid protein aggregates share common features of cytotoxicity.

1 reference

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21 January 2018

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

1 reference

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21 January 2018

Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide

1 reference

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21 January 2018

The 'molten globule' state is involved in the translocation of proteins across membranes?

1 reference

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21 January 2018

Insights into the molecular basis of the differing susceptibility of varying cell types to the toxicity of amyloid aggregates.

1 reference

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21 January 2018

Ultrastructural organization of amyloid fibrils by atomic force microscopy

1 reference

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21 January 2018

A single disulfide bond differentiates aggregation pathways of beta2-microglobulin.

1 reference

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21 January 2018

Solution conditions can promote formation of either amyloid protofilaments or mature fibrils from the HypF N-terminal domain

1 reference

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21 January 2018

Rationalization of the effects of mutations on peptide and protein aggregation rates.

1 reference

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21 January 2018

Designing conditions for in vitro formation of amyloid protofilaments and fibrils

1 reference

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21 January 2018

Induction of heme oxygenase-1 in the brains of scrapie-infected mice

1 reference

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21 January 2018

A one-hit model of cell death in inherited neuronal degenerations

1 reference

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21 January 2018

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

1 reference

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21 January 2018

Structural properties of prion protein protofibrils and fibrils: an experimental assessment of atomic models

1 reference

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21 January 2018

Selective targeting of synthetic antioxidants to mitochondria: towards a mitochondrial medicine for neurodegenerative diseases?

1 reference

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21 January 2018

Glycosaminoglycans and beta-amyloid, prion and tau peptides in neurodegenerative diseases

1 reference

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21 January 2018

Correlations of synaptic and pathological markers with cognition of the elderly

1 reference

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21 January 2018

Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Protein misfolding, evolution and disease

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

The structural basis of protein folding and its links with human disease

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Protein folding and misfolding

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

The behaviour of polyamino acids reveals an inverse side chain effect in amyloid structure formation

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity.

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

1 reference

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21 January 2018

Amyloid fibril formation by an SH3 domain

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

The role of antimicrobial peptides in animal defenses

1 reference

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21 January 2018

Assembly of A beta amyloid protofibrils: an in vitro model for a possible early event in Alzheimer's disease

1 reference

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21 January 2018

Channel formation by serum amyloid A: a potential mechanism for amyloid pathogenesis and host defense

1 reference

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21 January 2018

Monomer-monomer interactions drive the prepore to pore conversion of a beta-barrel-forming cholesterol-dependent cytolysin

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Rapid self-assembly of alpha-synuclein observed by in situ atomic force microscopy

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Pathological and functional amyloid formation orchestrated by the secretory pathway

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Effect of wild-type or mutant Parkin on oxidative damage, nitric oxide, antioxidant defenses, and the proteasome

1 reference

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21 January 2018

Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

The protofilament structure of insulin amyloid fibrils

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Formation of a membrane-active form of amyloid beta-protein in raft-like model membranes

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Interactions of amyloid beta-protein with various gangliosides in raft-like membranes: importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid

1 reference

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21 January 2018

Disruption of calcium homeostasis in the pathogenesis of Alzheimer's disease and other conformational diseases

1 reference

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21 January 2018

Alzheimer's beta-amyloid, human islet amylin, and prion protein fragment evoke intracellular free calcium elevations by a common mechanism in a hypothalamic GnRH neuronal cell line

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Structural changes of the prion protein in lipid membranes leading to aggregation and fibrillization

1 reference

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21 January 2018

Decreased levels of proteasome activity and proteasome expression in aging spinal cord

1 reference

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21 January 2018

The alternative conformations of amyloidogenic proteins and their multi-step assembly pathways

1 reference

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21 January 2018

Phospholipid catalysis of diabetic amyloid assembly

1 reference

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21 January 2018

Synthetic mammalian C-type natriuretic peptide forms large cation channels

1 reference

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21 January 2018

Mechanisms of amyloid beta protein-induced modification in ion transport systems: implications for neurodegenerative diseases

1 reference

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21 January 2018

Ion channel formation and membrane-linked pathologies of misfolded hydrophobic proteins: the role of dangerous unchaperoned molecules

1 reference

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21 January 2018

Properties of cytotoxic peptide-formed ion channels

1 reference

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21 January 2018

Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

1 reference

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21 January 2018

Neurodegenerative disease: amyloid pores from pathogenic mutations

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

1 reference

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21 January 2018

Alteration of free radical metabolism in the brain of mice infected with scrapie agent

1 reference

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21 January 2018

Annexin 5 and apolipoprotein E2 protect against Alzheimer's amyloid-beta-peptide cytotoxicity by competitive inhibition at a common phosphatidylserine interaction site

1 reference

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21 January 2018

A specific amyloid-beta protein assembly in the brain impairs memory

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Channel formation by a neurotoxic prion protein fragment

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Formation of amyloid-like fibrils by self-association of a partially unfolded fibronectin type III module

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

3D structure of Alzheimer's amyloid-beta(1-42) fibrils

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Amyloid formation by recombinant full-length prion proteins in phospholipid bicelle solutions

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Evidence for changes in the Alzheimer's disease brain cortical membrane structure mediated by cholesterol

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Impairment of membrane transport and signal transduction systems by amyloidogenic proteins

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Effect of amyloid beta-peptide on permeability transition pore: a comparative study.

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Rapid Anionic Micelle-mediated α-Synuclein Fibrillization in Vitro

1 reference

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21 January 2018

Structure of the cross-beta spine of amyloid-like fibrils

1 reference

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21 January 2018

Mitochondrial involvement in Parkinson's disease

1 reference

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21 January 2018

Induction of NADPH cytochrome P450 reductase by the Alzheimer beta-protein. Amyloid as a "foreign body".

1 reference

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21 January 2018

The changing face of glucagon fibrillation: structural polymorphism and conformational imprinting

1 reference

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Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis

1 reference

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21 January 2018

Cause of neural death in neurodegenerative diseases attributable to expansion of glutamine repeats

1 reference

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21 January 2018

Solid state NMR reveals a pH-dependent antiparallel beta-sheet registry in fibrils formed by a beta-amyloid peptide

1 reference

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21 January 2018

Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils

1 reference

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21 January 2018

The yeast prion Ure2p native-like assemblies are toxic to mammalian cells regardless of their aggregation state.

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization

1 reference

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21 January 2018

A review of early concepts of amyloid in context with contemporary chemical literature from 1839 to 1859.

1 reference

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21 January 2018

Microglia enhance beta-amyloid peptide-induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species.

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Amyloid ion channels: a common structural link for protein-misfolding disease

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Monitoring the process of HypF fibrillization and liposome permeabilization by protofibrils

1 reference

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21 January 2018

Natural beta-sheet proteins use negative design to avoid edge-to-edge aggregation

1 reference

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21 January 2018

Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

1 reference

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21 January 2018

How evolutionary pressure against protein aggregation shaped chaperone specificity

1 reference

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21 January 2018

PrP(C) association with lipid rafts in the early secretory pathway stabilizes its cellular conformation

1 reference

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21 January 2018

Frequencies of amino acid strings in globular protein sequences indicate suppression of blocks of consecutive hydrophobic residues

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Alzheimer's amyloid fibrils: structure and assembly

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Protein structural perturbation and aggregation on homogeneous surfaces

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease

1 reference

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21 January 2018

Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

The most infectious prion protein particles.

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Fibrillogenesis and cytotoxic activity of the amyloid-forming apomyoglobin mutant W7FW14F.

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Characterization of the nanoscale properties of individual amyloid fibrils

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Deposition of transthyretin in early stages of familial amyloidotic polyneuropathy: evidence for toxicity of nonfibrillar aggregates

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Oxidative stress and protein aggregation during biological aging

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Protein misfolding and aggregation: new examples in medicine and biology of the dark side of the protein world

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Heparin accelerates gelsolin amyloidogenesis

1 reference

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21 January 2018

HAMLET kills tumor cells by an apoptosis-like mechanism--cellular, molecular, and therapeutic aspects

1 reference

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21 January 2018

beta-Amyloid-mediated vasoactivity and vascular endothelial damage.

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers

1 reference

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21 January 2018

Progress towards a molecular-level structural understanding of amyloid fibrils

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Conformational constraints for amyloid fibrillation: the importance of being unfolded

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Assembly of the full-length recombinant mouse prion protein I. Formation of soluble oligomers.

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Murine apolipoprotein serum amyloid A in solution forms a hexamer containing a central channel

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

The influence of phospholipid membranes on bovine calcitonin peptide's secondary structure and induced neurotoxic effects

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Ideas of order for amyloid fibril structure

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Core and heterogeneity of beta2-microglobulin amyloid fibrils as revealed by H/D exchange

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Cholesterol, a modulator of membrane-associated Abeta-fibrillogenesis and neurotoxicity.

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Alpha-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signalling pathway

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Recombinant apoptin multimers kill tumor cells but are nontoxic and epitope-shielded in a normal-cell-specific fashion

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Binding of endostatin to phosphatidylserine-containing membranes and formation of amyloid-like fibers.

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Formation of amyloid fibers triggered by phosphatidylserine-containing membranes

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Surface-catalyzed amyloid fibril formation

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Collagen plays an active role in the aggregation of beta2-microglobulin under physiopathological conditions of dialysis-related amyloidosis

1 reference

https://api.crossref.org/works/10.1177/1073858407303428

21 January 2018

Identifiers

10.1177/1073858407303428

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17901260 AND SRC:MED&resulttype=core&format=json

8 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17901260 AND SRC:MED&resulttype=core&format=json

8 January 2020

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