Paxillin kinase linker (PKL) regulates Vav2 signaling during cell spreading and migration (Q36926620)

17 August 2017

Paxillin kinase linker (PKL) regulates Vav2 signaling during cell spreading and migration (English)

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17 August 2017

Matthew C Jones

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17 August 2017

Kazuya Machida

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2

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17 August 2017

Bruce J Mayer

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3

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17 August 2017

Christopher E Turner

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4

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17 August 2017

24 April 2013

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Molecular Biology of the Cell

17 August 2017

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17 August 2017

24

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17 August 2017

12

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17 August 2017

1882-1894

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describes a project that uses

17 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3681694/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

29 September 2017

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Phosphorylation of the cool-1/beta-Pix protein serves as a regulatory signal for the migration and invasive activity of Src-transformed cells

29 September 2017

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Paxillin-kinase-linker tyrosine phosphorylation regulates directional cell migration

29 September 2017

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Activated Vav2 modulates cellular invasion through Rac1 and Cdc42 in oral squamous cell carcinoma

29 September 2017

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VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2

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Persistent activation of Rac1 in squamous carcinomas of the head and neck: evidence for an EGFR/Vav2 signaling axis involved in cell invasion.

29 September 2017

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CdGAP associates with actopaxin to regulate integrin-dependent changes in cell morphology and motility

29 September 2017

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Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis

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Paxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamics

29 September 2017

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Overexpression of the VAV proto-oncogene product is associated with B-cell chronic lymphocytic leukaemia displaying loss on 13q.

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Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix

29 September 2017

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Activation of Vav/Rho GTPase signaling by CXCL12 controls membrane-type matrix metalloproteinase-dependent melanoma cell invasion

29 September 2017

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Rho GTPases and the control of cell behaviour

29 September 2017

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Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness

29 September 2017

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GIT1 activates p21-activated kinase through a mechanism independent of p21 binding

29 September 2017

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Epidermal Growth Factor-dependent Regulation of Cdc42 Is Mediated by the Src Tyrosine Kinase

29 September 2017

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Cell growth and metastasis in pancreatic cancer: is Vav the Rho'd to activation?

29 September 2017

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Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac

29 September 2017

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Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway

29 September 2017

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Adhesion assembly, disassembly and turnover in migrating cells -- over and over and over again

29 September 2017

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Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation

29 September 2017

1 reference

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Membrane-targeting is critical for the phosphorylation of Vav2 by activated EGF receptor

29 September 2017

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Vav2 is required for cell spreading

29 September 2017

1 reference

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The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL).

29 September 2017

1 reference

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RhoA is required for monocyte tail retraction during transendothelial migration

29 September 2017

1 reference

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Paxillin and focal adhesion signalling

29 September 2017

1 reference

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Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins

29 September 2017

1 reference

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Vav2 is an activator of Cdc42, Rac1, and RhoA

29 September 2017

1 reference

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Analysis of receptor signaling pathways by mass spectrometry: identification of vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors

29 September 2017

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The polarization of the motile cell

29 September 2017

1 reference

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Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling

29 September 2017

1 reference

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Rho GTPases control polarity, protrusion, and adhesion during cell movement

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681694

Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681694

The Par-Tiam1 complex controls persistent migration by stabilizing microtubule-dependent front-rear polarity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681694

Analysis of activated GAPs and GEFs in cell lysates

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681694

p85 beta-PIX is required for cell motility through phosphorylations of focal adhesion kinase and p38 MAP kinase

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681694

An alpha4 integrin-paxillin-Arf-GAP complex restricts Rac activation to the leading edge of migrating cells

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681694

Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681694

Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681694

Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681694

Cholecystokinin stimulates the recruitment of the Src-RhoA-phosphoinositide 3-kinase pathway by Vav-2 downstream of G(alpha13) in pancreatic acini

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681694

EGF receptor mediates adhesion-dependent activation of the Rac GTPase: a role for phosphatidylinositol 3-kinase and Vav2.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3681694

4 September 2018

Identifiers

DOI

10.1091/MBC.E12-09-0654

1 reference

17 August 2017

1 reference

17 August 2017

PubMed publication ID

23615439

1 reference