The oncogene HER2/neu (ERBB2) requires the hypoxia-inducible factor HIF-1 for mammary tumor growth and anoikis resistance (Q36890663)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23585570 AND SRC:MED&resulttype=core&format=json

28 February 2020

title

The oncogene HER2/neu (ERBB2) requires the hypoxia-inducible factor HIF-1 for mammary tumor growth and anoikis resistance (English)

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28 February 2020

6

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28 February 2020

author name string

Kelly A Whelan

1

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28 February 2020

Luciana P Schwab

2

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28 February 2020

Sergey V Karakashev

3

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28 February 2020

Lisa Franchetti

4

1 reference

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28 February 2020

Gregg J Johannes

5

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28 February 2020

Mauricio J Reginato

7

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28 February 2020

language of work or name

English

0 references

publication date

12 April 2013

1 reference

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Journal of Biological Chemistry

28 February 2020

number of pages

13

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

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28 February 2020

volume

288

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28 February 2020

issue

22

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28 February 2020

page(s)

15865-15877

1 reference

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Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer

28 February 2020

cites work

1 reference

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Modeling invasive breast cancer: growth factors propel progression of HER2-positive premalignant lesions

29 September 2017

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RETRACTED ARTICLE: HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

29 September 2017

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Analysis of tumor environmental response and oncogenic pathway activation identifies distinct basal and luminal features in HER2-related breast tumor subtypes

29 September 2017

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Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-):H2O2 ratio and confers anoikis resistance to tumors

29 September 2017

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Hypoxia Suppression of Bim and Bmf Blocks Anoikis and Luminal Clearing during Mammary Morphogenesis

29 September 2017

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Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning

29 September 2017

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ErbB2 requires integrin alpha5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells

29 September 2017

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Human cancers converge at the HIF-2alpha oncogenic axis.

29 September 2017

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Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

29 September 2017

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HIF-1: upstream and downstream of cancer metabolism

29 September 2017

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Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

29 September 2017

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Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth.

29 September 2017

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A naturally occurring HER2 carboxy-terminal fragment promotes mammary tumor growth and metastasis

29 September 2017

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Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains

29 September 2017

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Hypoxia-inducible factor 1alpha mediates anoikis resistance via suppression of alpha5 integrin

29 September 2017

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Cancer cell killing via ROS: to increase or decrease, that is the question

29 September 2017

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Hypoxia-induced resistance to anticancer drugs is associated with decreased senescence and requires hypoxia-inducible factor-1 activity

29 September 2017

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TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4

29 September 2017

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Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

29 September 2017

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Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis

29 September 2017

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MNK1 and MNK2 regulation in HER2-overexpressing breast cancer lines

29 September 2017

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Illuminating the center: mechanisms regulating lumen formation and maintenance in mammary morphogenesis

29 September 2017

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ERBB2-mediated transcriptional up-regulation of the alpha5beta1 integrin fibronectin receptor promotes tumor cell survival under adverse conditions.

29 September 2017

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

29 September 2017

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Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes.

29 September 2017

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29 September 2017

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cDNA microarray analysis of genes associated with ERBB2 (HER2/neu) overexpression in human mammary luminal epithelial cells

29 September 2017

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29 September 2017

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A new model for ductal carcinoma in situ suggests strategies for treatment

29 September 2017

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Hypoxia--a key regulatory factor in tumour growth

29 September 2017

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29 September 2017

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ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini

29 September 2017

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HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

29 September 2017

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Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth.

29 September 2017

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HIF-1: mediator of physiological and pathophysiological responses to hypoxia

29 September 2017

1 reference

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Adrenomedullin gene expression is developmentally regulated and induced by hypoxia in rat ventricular cardiac myocytes

29 September 2017

1 reference

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Integrins, oncogenes, and anchorage independence.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668743

Disruption of epithelial cell-matrix interactions induces apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668743

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

29 September 2017

1 reference

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Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease

29 September 2017

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A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells

29 September 2017

1 reference

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Surviving without oxygen: Hypoxia regulation of mammary morphogenesis and anoikis

27 June 2018

1 reference

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Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668743

HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells.

4 September 2018

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Expression of carbonic anhydrase IX in breast is associated with malignant tissues and is related to overexpression of c-erbB2.

4 September 2018

1 reference

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Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3668743

Hypoxia-Inducible Factor-1 Expression Predicts a Poor Response to Primary Chemoendocrine Therapy and Disease-Free Survival in Primary Human Breast Cancer

4 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074/JBC.M112.426999

21 January 2018

Identifiers

DOI

10.1074/JBC.M112.426999

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23585570 AND SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23585570 AND SRC:MED&resulttype=core&format=json

28 February 2020

PubMed publication ID

23585570

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23585570 AND SRC:MED&resulttype=core&format=json