Immunomodulating role of bisphosphonates on human gamma delta T cells: an intriguing and promising aspect of their antitumour activity (Q36871994)

16 August 2017

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title

Immunomodulating role of bisphosphonates on human gamma delta T cells: an intriguing and promising aspect of their antitumour activity (English)

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16 August 2017

Galluzzo S

1

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16 August 2017

Santini D

2

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16 August 2017

Vincenzi B

3

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16 August 2017

Caccamo N

4

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16 August 2017

Meraviglia F

5

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16 August 2017

Salerno A

6

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16 August 2017

Dieli F

7

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16 August 2017

Tonini G

8

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16 August 2017

language of work or name

English

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publication date

1 July 2007

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Expert Opinion on Therapeutic Targets

16 August 2017

published in

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16 August 2017

volume

11

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16 August 2017

issue

7

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16 August 2017

page(s)

941-954

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Structure-activity relationships of various bisphosphonates

16 August 2017

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21 January 2018

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Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.

21 January 2018

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The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: A clue to the mechanism of action of nitrogen-containing bisphosphonates

21 January 2018

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The role of prenylated small GTP-binding proteins in the regulation of osteoclast function

21 January 2018

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Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo

21 January 2018

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Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases.

21 January 2018

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A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates.

21 January 2018

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The ability of statins to inhibit bone resorption is directly related to their inhibitory effect on HMG-CoA reductase activity

21 January 2018

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Zoledronic acid treatment of 5T2MM-bearing mice inhibits the development of myeloma bone disease: evidence for decreased osteolysis, tumor burden and angiogenesis, and increased survival.

21 January 2018

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An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis.

21 January 2018

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Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid

21 January 2018

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Zoledronate sensitizes endothelial cells to tumor necrosis factor-induced programmed cell death: evidence for the suppression of sustained activation of focal adhesion kinase and protein kinase B/Akt

21 January 2018

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Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity

21 January 2018

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The third-generation bisphosphonate zoledronate synergistically augments the anti-Ph leukemia activity of imatinib mesylate

21 January 2018

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Zoledronic acid inhibits visceral metastases in the 4T1/luc mouse breast cancer model

21 January 2018

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Induction of gammadelta T-lymphocyte effector functions by bisphosphonate zoledronic acid in cancer patients in vivo.

21 January 2018

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Identification of a bisphosphonate that inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase

21 January 2018

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Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro

21 January 2018

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New insights into the actions of bisphosphonate zoledronic acid in breast cancer cells by dual RhoA-dependent and -independent effects

21 January 2018

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Nitrogen containing bisphosphonates induce apoptosis and inhibit the mevalonate pathway, impairing Ras membrane localization in prostate cancer cells

21 January 2018

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The bisphosphonate zoledronic acid impairs Ras membrane [correction of impairs membrane] localisation and induces cytochrome c release in breast cancer cells

21 January 2018

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Natural and synthetic non-peptide antigens recognized by human gamma delta T cells.

21 January 2018

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Vgamma2Vdelta2 T-cell receptor-mediated recognition of aminobisphosphonates

21 January 2018

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Spontaneous resistance to acute T-cell leukaemias in TCRV gamma 1.1J gamma 4C gamma 4 transgenic mice

21 January 2018

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[gamma][delta] cells: a right time and a right place for a conserved third way of protection

21 January 2018

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Differential requirements for antigen or homeostatic cytokines for proliferation and differentiation of human Vgamma9Vdelta2 naive, memory and effector T cell subsets.

21 January 2018

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21 January 2018

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Self-recognition of CD1 by gamma/delta T cells: implications for innate immunity

21 January 2018

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Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gamma delta T cells.

21 January 2018

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Recognition by human V gamma 9/V delta 2 T cells of a GroEL homolog on Daudi Burkitt's lymphoma cells

21 January 2018

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The interplay between classical and alternative isoprenoid biosynthesis controls gammadelta T cell bioactivity of Listeria monocytogenes.

21 January 2018

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Control of self‐reactive cytotoxic T lymphocytes expressing γδ T cell receptors by natural killer inhibitory receptors

21 January 2018

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Gamma/delta T cell clones and natural killer cell clones mediate distinct patterns of non-major histocompatibility complex-restricted cytolysis

21 January 2018

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Human gamma delta T cells recognize alkylamines derived from microbes, edible plants, and tea: implications for innate immunity.

21 January 2018

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Statins prevent bisphosphonate-induced gamma,delta-T-cell proliferation and activation in vitro.

21 January 2018

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21 January 2018

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21 January 2018

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Disseminated tuberculosis in interferon gamma gene-disrupted mice

21 January 2018

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An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection

21 January 2018

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Novel human immunodeficiencies reveal the essential role of type-I cytokines in immunity to intracellular bacteria

21 January 2018

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Biology of T memory type 1 cells

21 January 2018

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Gammadelta T cells for immune therapy of patients with lymphoid malignancies

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.11.7.941

Type I IFN-mediated enhancement of anti-leukemic cytotoxicity of gammadelta T cells expanded from peripheral blood cells by stimulation with zoledronate.

21 January 2018

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Perforin-dependent killing of tumor cells by Vgamma1Vdelta1-bearing T-cells.

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.11.7.941

Cytotoxic effects of gammadelta T cells expanded ex vivo by a third generation bisphosphonate for cancer immunotherapy.

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.11.7.941

Effect of human natural killer and gammadelta T cells on the growth of human autologous melanoma xenografts in SCID mice

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.11.7.941

Efficacy of the third-generation bisphosphonate, zoledronic acid alone and combined with anti-cancer agents against small cell lung cancer cell lines

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.11.7.941

Human gammadelta T cells as mediators of chimaeric-receptor redirected anti-tumour immunity

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.11.7.941

In vitro cytoreductive effects on multiple myeloma cells induced by bisphosphonates

21 January 2018

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In vivo immunomanipulation of V gamma 9V delta 2 T cells with a synthetic phosphoantigen in a preclinical nonhuman primate model

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.11.7.941

Drug-induced expansion and differentiation of V gamma 9V delta 2 T cells in vivo: the role of exogenous IL-2.

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.11.7.941

Regulation of cutaneous malignancy by gammadelta T cells

21 January 2018

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https://api.crossref.org/works/10.1517/14728222.11.7.941

Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancer

21 January 2018

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Efficacy of Pamidronate in Reducing Skeletal Events in Patients with Advanced Multiple Myeloma

21 January 2018

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10.1517/14728222.11.7.941

21 January 2018

Identifiers

DOI

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16 August 2017

1 reference