A subset of high-titer anti-factor VIII A2 domain antibodies is responsive to treatment with factor VIII. (Q36825812)

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6 March 2020

title

A subset of high-titer anti-factor VIII A2 domain antibodies is responsive to treatment with factor VIII (English)

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6 March 2020

7

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6 March 2020

author name string

Joshua Eubanks

1

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6 March 2020

W Hunter Baldwin

2

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6 March 2020

Rebecca Markovitz

3

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6 March 2020

Ernest T Parker

4

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6 March 2020

Courtney Cox

5

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6 March 2020

Christine L Kempton

6

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6 March 2020

language of work or name

English

0 references

publication date

29 January 2016

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6 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26825708 AND SRC:MED&resulttype=core&format=json

6 March 2020

volume

127

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6 March 2020

issue

16

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6 March 2020

page(s)

2028-2034

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The diversity of the immune response to the A2 domain of human factor VIII

6 March 2020

cites work

1 reference

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Discrepancy between one-stage and chromogenic factor VIII activity assay results can lead to misdiagnosis of haemophilia A phenotype.

29 September 2017

1 reference

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Non-classical anti-factor VIII C2 domain antibodies are pathogenic in a murine in vivo bleeding model.

29 September 2017

1 reference

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Nonclassical anti-C2 domain antibodies are present in patients with factor VIII inhibitors

29 September 2017

1 reference

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Antihuman factor VIII C2 domain antibodies in hemophilia A mice recognize a functionally complex continuous spectrum of epitopes dominated by inhibitors of factor VIII activation

29 September 2017

1 reference

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The humoral response to human factor VIII in hemophilia A mice

29 September 2017

1 reference

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High level expression of recombinant porcine coagulation factor VIII.

29 September 2017

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How to measure and predict the molar absorption coefficient of a protein

29 September 2017

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Potentiation of thrombin generation in hemophilia A plasma by coagulation factor VIII and characterization of antibody-specific inhibition

29 September 2017

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The A2 Subunit of Factor VIIIa Modulates the Active Site of Factor IXa

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4841042

Slowed release of thrombin-cleaved factor VIII from von Willebrand factor by a monoclonal and a human antibody is a novel mechanism for factor VIII inhibition

27 June 2018

1 reference

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Further characterization of factor VIII-deficient mice created by gene targeting: RNA and protein studies

27 June 2018

1 reference

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Familial discrepancy between the one-stage and two-stage factor VIII methods in a subgroup of patients with haemophilia A.

27 June 2018

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Molecular characterization of commercial porcine factor VIII concentrate

27 June 2018

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Proceedings: A more uniform measurement of factor VIII inhibitors

27 June 2018

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Mitral valve repair in a Jehovah's witness with haemophilia A with high-titre inhibitor

27 June 2018

1 reference

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Kinetics of factor VIII:C inhibitors and treatment response in severe hemophilia A patients

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4841042

One-stage and chromogenic FVIII:C assay discrepancy in mild haemophilia A and the relationship with the mutation and bleeding phenotype

5 September 2018

1 reference

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Acquired hemophilia A in the United Kingdom: a 2-year national surveillance study by the United Kingdom Haemophilia Centre Doctors' Organisation.

5 September 2018

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Neutralization of antifactor VIII inhibitors by recombinant porcine factor VIII.

5 September 2018

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Contribution of factor VIIIa A2 and A3-C1-C2 subunits to the affinity for factor IXa in factor Xase

5 September 2018

1 reference

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Reduction of the antigenicity of factor VIII toward complex inhibitory antibody plasmas using multiply-substituted hybrid human/porcine factor VIII molecules.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4841042

Residues Glu2181-Val2243 contain a major determinant of the inhibitory epitope in the C2 domain of human factor VIII.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4841042

The inhibitor antibody response is more complex in hemophilia A patients than in most nonhemophiliacs with factor VIII autoantibodies. Recombinate and Kogenate Study Groups.

5 September 2018

1 reference

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Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4841042

Structural basis for the decreased procoagulant activity of human factor VIII compared to the porcine homolog.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4841042

Factor VIII and factor VIIIa

5 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26825708

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Residues 484-508 contain a major determinant of the inhibitory epitope in the A2 domain of human factor VIII

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26825708

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inactivation of factor VIII coagulant activity by two different types of human antibodies

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26825708

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1182/BLOOD-2015-09-670034

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26825708 AND SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26825708 AND SRC:MED&resulttype=core&format=json

6 March 2020

PubMed publication ID

26825708

1 reference