Progress for dengue virus diseases. Towards the NS2B-NS3pro inhibition for a therapeutic-based approach (Q36825107)

16 August 2017

title

Progress for dengue virus diseases. Towards the NS2B-NS3pro inhibition for a therapeutic-based approach (English)

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16 August 2017

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Sonia Michaela Melino

object named as

Sonia Melino

series ordinal

1

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Maurizio Paci

series ordinal

2

object named as

Maurizio Paci

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16 August 2017

language of work or name

English

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publication date

17 May 2007

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16 August 2017

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16 August 2017

volume

274

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16 August 2017

issue

12

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16 August 2017

page(s)

2986-3002

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https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

16 August 2017

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Dengue virus infection: Epidemiology, pathogenesis, clinical presentation, diagnosis, and prevention

21 January 2018

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https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Pathogenesis of dengue: challenges to molecular biology

21 January 2018

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https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Antibody-dependent enhancement of infection and the pathogenesis of viral disease

21 January 2018

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https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Failure of secondary infection with American genotype dengue 2 to cause dengue haemorrhagic fever

21 January 2018

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https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Growth-restricted dengue virus mutants containing deletions in the 5' noncoding region of the RNA genome

21 January 2018

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https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Control of Translation by the 5'- and 3'-Terminal Regions of the Dengue Virus Genome

21 January 2018

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https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

The machinery for flavivirus fusion with host cell membranes

21 January 2018

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https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Ring-expanded ("fat") nucleoside and nucleotide analogues exhibit potent in vitro activity against flaviviridae NTPases/helicases, including those of the West Nile virus, hepatitis C virus, and Japanese encephalitis virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Mutational Evidence for an Internal Fusion Peptide in Flavivirus Envelope Protein E

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Epitopes on the dengue 1 virus envelope protein recognized by neutralizing IgM monoclonal antibodies

21 January 2018

1 reference

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Folding and dimerization of tick-borne encephalitis virus envelope proteins prM and E in the endoplasmic reticulum

21 January 2018

1 reference

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An analysis of the antibody response against West Nile virus E protein purified by SDS-PAGE indicates that this protein does not contain sequential epitopes for efficient induction of neutralizing antibodies

21 January 2018

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The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution

21 January 2018

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Flavivirus genome organization, expression, and replication

21 January 2018

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https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Immunolocalization of the dengue virus nonstructural glycoprotein NS1 suggests a role in viral RNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Dengue virus nonstructural protein 1 is expressed in a glycosyl-phosphatidylinositol-linked form that is capable of signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

The NS 3 nonstructural protein of flaviviruses contains an RNA triphosphatase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Recombinant dengue virus type 1 NS3 protein exhibits specific viral RNA binding and NTPase activity regulated by the NS5 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Dengue 2 virus NS2B and NS3 form a stable complex that can cleave NS3 within the helicase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Flavivirus premembrane protein cleavage and spike heterodimer secretion require the function of the viral proteinase NS3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Internal proteolysis of the NS3 protein specified by dengue virus 2.

21 January 2018

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https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Computer-assisted identification of a putative methyltransferase domain in NS5 protein of flaviviruses and lambda 2 protein of reovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Recombinant dengue type 1 virus NS5 protein expressed in Escherichia coli exhibits RNA-dependent RNA polymerase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

The future of dengue vaccines

21 January 2018

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Review on flavivirus vaccine development. Proceedings of a meeting jointly organised by the World Health Organization and the Thai Ministry of Public Health, 26-27 April 2004, Bangkok, Thailand

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity

21 January 2018

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https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Safety and efficacy of chimeric yellow Fever-dengue virus tetravalent vaccine formulations in nonhuman primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Update on antiviral DNA vaccine research (1998-2000).

21 January 2018

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https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Synergistic neutralizing antibody response to a dengue virus type 2 DNA vaccine by incorporation of lysosome-associated membrane protein sequences and use of plasmid expressing GM-CSF.

21 January 2018

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DNA vaccines for flaviviruses

21 January 2018

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https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Dengue tetravalent DNA vaccine inducing neutralizing antibody and anamnestic responses to four serotypes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Lethal 17D yellow fever encephalitis in mice. I. Passive protection by monoclonal antibodies to the envelope proteins of 17D yellow fever and dengue 2 viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Passive protection studies in mice with monoclonal antibodies directed against the non-structural protein NS3 of dengue 1 virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Neutralizing (54K) and non-neutralizing (54K and 48K) monoclonal antibodies against structural and non-structural yellow fever virus proteins confer immunity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Protection of mice against dengue 2 virus encephalitis by immunization with the dengue 2 virus non-structural glycoprotein NS1.

21 January 2018

1 reference

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The dengue virus nonstructural-1 protein (NS1) generates antibodies to common epitopes on human blood clotting, integrin/adhesin proteins and binds to human endothelial cells: potential implications in haemorrhagic fever pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

A DNA vaccine expressing dengue type 2 virus premembrane and envelope genes induces neutralizing antibody and memory B cells in mice

21 January 2018

1 reference

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Dengue type 2 virus subviral extracellular particles produced by a stably transfected mammalian cell line and their evaluation for a subunit vaccine

21 January 2018

1 reference

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Simultaneous immunization with DNA and protein vaccines against Japanese encephalitis or dengue synergistically increases their own abilities to induce neutralizing antibody in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

A recombinant capsid protein from Dengue-2 induces protection in mice against homologous virus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Heparan sulfate-mediated binding of infectious dengue virus type 2 and yellow fever virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Sulfated seaweed polysaccharides as antiviral agents

21 January 2018

1 reference

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Anti-herpes simplex virus activity of sulfated galactans from the red seaweeds Gymnogongrus griffithsiae and Cryptonemia crenulata.

21 January 2018

1 reference

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Novel DL-galactan hybrids from the red seaweed Gymnogongrus torulosus are potent inhibitors of herpes simplex virus and dengue virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Salicylates inhibit flavivirus replication independently of blocking nuclear factor kappa B activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Mechanisms of dengue virus-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Cellular immune activation in children with acute dengue virus infections is modulated by apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Interferon, ribavirin, 6-azauridine and glycyrrhizin: antiviral compounds active against pathogenic flaviviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Modulation of Dengue virus infection in human cells by alpha, beta, and gamma interferons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Interferon inhibits dengue virus infection by preventing translation of viral RNA through a PKR-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Use of a flavivirus RNA-dependent RNA polymerase assay to investigate the antiviral activity of selected compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Inducible nitric oxide synthase (iNOS) expression in monocytes during acute Dengue Fever in patients and during in vitro infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Nitric oxide radical suppresses replication of wild-type dengue 2 viruses in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Antiviral action of nitric oxide on dengue virus type 2 replication

21 January 2018

1 reference

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21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Viral Proteases: Evolution of Diverse Structural Motifs to Optimize Function

21 January 2018

1 reference

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Simultaneous vs sequential initiation of therapy with indinavir, zidovudine, and lamivudine for HIV-1 infection: 100-week follow-up

21 January 2018

1 reference

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A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team

21 January 2018

1 reference

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An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus

21 January 2018

1 reference

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Preclinical profile of VX-950, a potent, selective, and orally bioavailable inhibitor of hepatitis C virus NS3-4A serine protease

21 January 2018

1 reference

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21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site

21 January 2018

1 reference

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A structural perspective of the flavivirus life cycle

21 January 2018

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Recent advances in the molecular biology of west nile virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Catalytic hydroxyl/amine dyads within serine proteases

21 January 2018

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https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

On the size of the active site in proteases. I. Papain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Processing of nonstructural proteins NS4A and NS4B of dengue 2 virus in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Homology model of the dengue 2 virus NS3 protease: putative interactions with both substrate and NS2B cofactor.

21 January 2018

1 reference

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Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Purified NS2B/NS3 serine protease of dengue virus type 2 exhibits cofactor NS2B dependence for cleavage of substrates with dibasic amino acids in vitro

21 January 2018

1 reference

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The active essential CFNS3d protein complex

21 January 2018

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Hepatitis C NS3 protease: restoration of NS4A cofactor activity by N-biotinylation of mutated NS4A using synthetic peptides

21 January 2018

1 reference

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Identification of residues in the dengue virus type 2 NS2B cofactor that are critical for NS3 protease activation

21 January 2018

1 reference

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Cotranslational Membrane Insertion of the Serine Proteinase Precursor NS2B-NS3(Pro) of Dengue Virus Type 2 Is Required for Efficient in Vitro Processing and Is Mediated through the Hydrophobic Regions of NS2B

21 January 2018

1 reference

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Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Self-association of the C-terminal domain of the hepatitis-C virus core protein.

21 January 2018

1 reference

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The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism

21 January 2018

1 reference

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Dengue virus NS3 serine protease. Crystal structure and insights into interaction of the active site with substrates by molecular modeling and structural analysis of mutational effects

21 January 2018

1 reference

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Crystal structure of Dengue virus NS3 protease in complex with a Bowman-Birk inhibitor: implications for flaviviral polyprotein processing and drug design

21 January 2018

1 reference

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Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.

21 January 2018

1 reference

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Efficient cleavage of ribosome-associated poly(A)-binding protein by enterovirus 3C protease

21 January 2018

1 reference

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Foot-and-mouth disease virus leader proteinase: involvement of C-terminal residues in self-processing and cleavage of eIF4GI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Probing the substrate specificity of the dengue virus type 2 NS3 serine protease by using internally quenched fluorescent peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Cleavage preference distinguishes the two-component NS2B–NS3 serine proteinases of Dengue and West Nile viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1742-4658.2007.05831.X

Insights to substrate binding and processing by West Nile Virus NS3 protease through combined modeling, protease mutagenesis, and kinetic studies

21 January 2018

1 reference

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Competitive inhibition of the dengue virus NS3 serine protease by synthetic peptides representing polyprotein cleavage sites

21 January 2018

1 reference

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Synthetic inhibitors of elastase

21 January 2018

1 reference

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Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design

21 January 2018

1 reference

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Peptide inhibitors of Dengue virus NS3 protease. Part 1: Warhead

21 January 2018

1 reference

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Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors.

21 January 2018

1 reference

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Identification and characterization of nonsubstrate based inhibitors of the essential dengue and West Nile virus proteases

21 January 2018

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Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease.

21 January 2018

1 reference

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Substrate specificity of human kallikrein 6: salt and glycosaminoglycan activation effects

21 January 2018

1 reference

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T-Coffee: A novel method for fast and accurate multiple sequence alignment

21 January 2018

1 reference

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N-terminal domains of putative helicases of flavi- and pestiviruses may be serine proteases

21 January 2018

1 reference

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10.1111/J.1742-4658.2007.05831.X

21 January 2018

Identifiers

DOI

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16 August 2017

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