Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections (Q36823712)

16 August 2017

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title

Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections (English)

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calcineurin a catalytic subunit

16 August 2017

main subject

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GeneDB

invasive fungal infections

6 February 2019

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5

Joseph Heitman

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16 August 2017

4

John R Perfect

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16 August 2017

1

William J Steinbach

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16 August 2017

Jennifer L Reedy

2

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16 August 2017

Robert A Cramer

series ordinal

3

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16 August 2017

language of work or name

English

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publication date

1 June 2007

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Nature Reviews Microbiology

16 August 2017

published in

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16 August 2017

volume

5

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16 August 2017

issue

6

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16 August 2017

page(s)

418-430

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A rare genotype of Cryptococcus gattii caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada)

16 August 2017

cites work

1 reference

Trends in the postmortem epidemiology of invasive fungal infections at a university hospital

31 March 2020

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Nosocomial bloodstream infections in United States hospitals: a three-year analysis

31 March 2020

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Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients

31 March 2020

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31 March 2020

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The direct cost and incidence of systemic fungal infections

31 March 2020

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Advances in combating fungal diseases: vaccines on the threshold

31 March 2020

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Calcineurin: a calcium- and calmodulin-binding protein of the nervous system

31 March 2020

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Good fungi gone bad: the corruption of calcineurin

31 March 2020

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Dopamine- and cAMP-regulated phosphoprotein DARPP-32: phosphorylation of Ser-137 by casein kinase I inhibits dephosphorylation of Thr-34 by calcineurin

31 March 2020

1 reference

Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity

31 March 2020

1 reference

Dephosphorylation of calponin by type 2B protein phosphatase

31 March 2020

1 reference

Calcineurin and vacuolar-type H -ATPase modulate macrophage effector functions

31 March 2020

1 reference

Calcineurin promotes the expression of monocyte chemoattractant protein-1 in vascular myocytes and mediates vascular inflammation

31 March 2020

1 reference

Calcineurin mediates alpha-adrenergic stimulation of Na ,K( )-ATPase activity in renal tubule cells

31 March 2020

1 reference

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

31 March 2020

1 reference

Calcineurin. Structure, function, and inhibition

31 March 2020

1 reference

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

31 March 2020

1 reference

Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: one in the presence and one in the absence of CsA

31 March 2020

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Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function

31 March 2020

1 reference

Signals transduced by Ca(2 )/calcineurin and NFATc3/c4 pattern the developing vasculature

31 March 2020

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Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin.

31 March 2020

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Reversible blockade of experience-dependent plasticity by calcineurin in mouse visual cortex.

31 March 2020

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Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number

31 March 2020

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Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons

31 March 2020

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A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis

31 March 2020

1 reference

Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain

31 March 2020

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Prevention of Cardiac Hypertrophy in Mice by Calcineurin Inhibition

31 March 2020

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Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis

31 March 2020

1 reference

NFAT and Osterix cooperatively regulate bone formation

31 March 2020

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Skeletal muscle hypertrophy is mediated by a Ca2 -dependent calcineurin signalling pathway

31 March 2020

1 reference

Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of acute graft versus host disease after marrow transplantation for leukemia

31 March 2020

1 reference

Long-term Safety and Efficacy of Tacrolimus Ointment for the Treatment of Atopic Dermatitis in Children

31 March 2020

1 reference

Trial of cyclosporin in corticosteroid-dependent chronic severe asthma

31 March 2020

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Infliximab treatment in combination with cyclosporin A in patients with severe refractory rheumatoid arthritis

31 March 2020

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Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin

31 March 2020

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Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

31 March 2020

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Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

31 March 2020

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X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

31 March 2020

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Treatment of murine cryptococcosis with cyclosporin-A in normal and athymic mice

31 March 2020

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Calcineurin is required for virulence of Cryptococcus neoformans

31 March 2020

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Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans

31 March 2020

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Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans

31 March 2020

1 reference

Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans

31 March 2020

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Calcium- and calcineurin-independent roles for calmodulin in Cryptococcus neoformans morphogenesis and high-temperature growth

31 March 2020

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Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans

31 March 2020

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Calcineurin-binding protein Cbp1 directs the specificity of calcineurin-dependent hyphal elongation during mating in Cryptococcus neoformans

31 March 2020

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Phospholipid-binding protein Cts1 controls septation and functions coordinately with calcineurin in Cryptococcus neoformans

31 March 2020

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The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function

31 March 2020

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Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin

31 March 2020

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Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans

31 March 2020

1 reference

Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans

31 March 2020

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Cryptococcus neoformans in organ transplant recipients: impact of calcineurin-inhibitor agents on mortality

31 March 2020

1 reference

Antifungal attributes of immunosuppressive agents: new paradigms in management and elucidating the pathophysiologic basis of opportunistic mycoses in organ transplant recipients

31 March 2020

1 reference

Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens

31 March 2020

1 reference

The epidemiology of sepsis in the United States from 1979 through 2000

31 March 2020

1 reference

Changes in the spectrum and risk factors for invasive candidiasis in liver transplant recipients: prospective, multicenter, case-controlled study1

31 March 2020

1 reference

Calcineurin is essential for survival during membrane stress in Candida albicans

31 March 2020

1 reference

Calcineurin is essential for virulence in Candida albicans

31 March 2020

1 reference

Calcineurin is essential for Candida albicans survival in serum and virulence

31 March 2020

1 reference

Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence

31 March 2020

1 reference

Role of calcineurin in stress resistance, morphogenesis, and virulence of a Candida albicans wild-type strain

31 March 2020

1 reference

Candida Albicans: a molecular revolution built on lessons from budding yeast

31 March 2020

1 reference

Virulence factors of Candida albicans

31 March 2020

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Putative virulence factors of Candida albicans

31 March 2020

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Candida albicans hyphal formation and the expression of the Efg1-regulated proteinases Sap4 to Sap6 are required for the invasion of parenchymal organs

31 March 2020

1 reference

Nonfilamentous C. albicans Mutants Are Avirulent

31 March 2020

1 reference

Dimorphism and virulence in Candida albicans

31 March 2020

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Candida albicans proteinases and host/pathogen interactions

31 March 2020

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Adhesins in Candida albicans

31 March 2020

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Essential role of the Candida albicans transglutaminase substrate, hyphal wall protein 1, in lethal oroesophageal candidiasis in immunodeficient mice

31 March 2020

1 reference

CRZ1, a target of the calcineurin pathway in Candida albicans

31 March 2020

1 reference

The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans

31 March 2020

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Functional characterization of the Candida albicans CRZ1 gene encoding a calcineurin-regulated transcription factor

31 March 2020

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Calcineurin-dependent regulation of Crz1p nuclear export requires Msn5p and a conserved calcineurin docking site

31 March 2020

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Calcineurin signaling in Saccharomyces cerevisiae: how yeast go crazy in response to stress

31 March 2020

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Tcn1p/Crz1p, a calcineurin-dependent transcription factor that differentially regulates gene expression inSaccharomyces cerevisiae

31 March 2020

1 reference

Promoter sequences regulated by the calcineurin-activated transcription factor Crz1 in the yeast ENA1 gene.

31 March 2020

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Calcineurin-dependent nuclear import of the transcription factor Crz1p requires Nmd5p

31 March 2020

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Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast

31 March 2020

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Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation

31 March 2020

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Genome-wide analysis of gene expression regulated by the calcineurin/Crz1p signaling pathway in Saccharomyces cerevisiae

31 March 2020

1 reference

The CRH family coding for cell wall glycosylphosphatidylinositol proteins with a predicted transglycosidase domain affects cell wall organization and virulence of Candida albicans.

31 March 2020

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Genetic architecture of Hsp90-dependent drug resistance

31 March 2020

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Hph1p and Hph2p, novel components of calcineurin-mediated stress responses in Saccharomyces cerevisiae

31 March 2020

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Potent synergism of the combination of fluconazole and cyclosporine in Candida albicans

31 March 2020

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Fluconazole plus cyclosporine: a fungicidal combination effective against experimental endocarditis due to Candida albicans

31 March 2020

1 reference

Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei

31 March 2020

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Anti-Candida drugs--the biochemical basis for their activity

31 March 2020

1 reference

Fungicidal synergism of fluconazole and cyclosporine in Candida albicans is not dependent on multidrug efflux transporters encoded by the CDR1, CDR2, CaMDR1, and FLU1 genes.

31 March 2020

1 reference

Immunotherapy with tacrolimus (FK506) does not select for resistance to calcineurin inhibitors in Candida albicans isolates from liver transplant patients

31 March 2020

1 reference

Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy

31 March 2020

1 reference

Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi

31 March 2020

1 reference

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

31 March 2020

1 reference

Cell biology. A fungal Achilles' heel

31 March 2020

1 reference

Trends in mortality due to invasive mycotic diseases in the United States, 1980-1997.

31 March 2020

1 reference

Bad bugs need drugs: an update on the development pipeline from the Antimicrobial Availability Task Force of the Infectious Diseases Society of America

31 March 2020

1 reference

The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans

31 March 2020

1 reference

Cloning and sequence analysis of cnaA gene encoding the catalytic subunit of calcineurin from Aspergillus oryzae

31 March 2020

1 reference

Functional analysis of the calcineurin-encoding gene cnaA from Aspergillus oryzae: evidence for its putative role in stress adaptation

31 March 2020

1 reference

The Aspergillus niger cypA gene encodes a cyclophilin that mediates sensitivity to the immunosuppressant cyclosporin A.

31 March 2020

1 reference

Regulation of aflatoxin production by Ca(2 )/calmodulin-dependent protein phosphorylation and dephosphorylation

31 March 2020

1 reference

Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus

31 March 2020

1 reference

Functional characterization of the Aspergillus fumigatus calcineurin

31 March 2020

1 reference

The akuB(KU80) mutant deficient for nonhomologous end joining is a powerful tool for analyzing pathogenicity in Aspergillus fumigatus

31 March 2020

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Effects of methylprednisolone and cyclosporine A on fungal growth in vitro

31 March 2020

1 reference

Structural and biological characterization of chromofungin, the antifungal chromogranin A-(47-66)-derived peptide

31 March 2020

1 reference

Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth in vitro in Aspergillus species

31 March 2020

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In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus

31 March 2020

1 reference

In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients

31 March 2020

1 reference

Trends in Risk Profiles for and Mortality Associated with Invasive Aspergillosis among Liver Transplant Recipients

31 March 2020

1 reference

Pathogenesis of pulmonary aspergillosis. Granulocytopenia versus cyclosporine and methylprednisolone-induced immunosuppression

31 March 2020

1 reference

Invasive aspergillosis in mice immunosuppressed with cyclosporin A, tacrolimus (FK506), or sirolimus (rapamycin).

31 March 2020

1 reference

Comparative safety of amphotericin B lipid complex and amphotericin B deoxycholate as aerosolized antifungal prophylaxis in lung-transplant recipients

31 March 2020

1 reference

A Randomized Trial of Inhaled Cyclosporine in Lung-Transplant Recipients

31 March 2020

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Aerosol cyclosporin therapy in lung transplant recipients with bronchiolitis obliterans

31 March 2020

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Calcineurin is required for Candida albicans to survive calcium stress in serum

31 March 2020

1 reference

Effects of cyclosporine in experimental cryptococcal meningitis.

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1038/NRMICRO1680

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release_cagq4zmk3rhuhbas7agtuzsszq

16 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/cagq4zmk3rhuhbas7agtuzsszq

mapped directly with Wikidata item

24 November 2022

based on heuristic

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