4-Hydroxyhexenal (HHE) Impairs Glutamate Transport in Astrocyte Cultures (Q36821506)

16 August 2017

4-Hydroxyhexenal (HHE) impairs glutamate transport in astrocyte cultures (English)

1 reference

16 August 2017

4-Hydroxyhexenal (HHE) Impairs Glutamate Transport in Astrocyte Cultures (English)

1 reference

Crossref

DOI

10.3233/JAD-2012-120409

https://api.crossref.org/works/10.3233/JAD-2012-120409

5 January 2025

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Mark A. Lovell

1

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5 January 2025

Melissa A. Bradley

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2

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5 January 2025

Shuling X. Fister

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5 January 2025

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English

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National Center for Biotechnology Information

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publication date

1 January 2012

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16 August 2017

2012

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National Center for Biotechnology Information

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full work available at URL

5 January 2025

https://europepmc.org/articles/pmc3646088?pdf=render

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5 January 2025

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open access

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https://europepmc.org/articles/PMC3646088?pdf=render

5 January 2025

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:22766736

https://doi.org/10.3233/jad-2012-120409

5 January 2025

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open access

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5 January 2025

1 reference

Crossref

DOI

10.3233/JAD-2012-120409

https://api.crossref.org/works/10.3233/JAD-2012-120409

Journal of Alzheimer's Disease

5 January 2025

published in

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16 August 2017

32

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16 August 2017

1

1 reference

16 August 2017

139-146

1 reference

Elevated 4-hydroxyhexenal in Alzheimer's disease (AD) progression

16 August 2017

1 reference

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Aberrant detergent-insoluble excitatory amino acid transporter 2 accumulates in Alzheimer disease.

29 September 2017

1 reference

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Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease.

29 September 2017

1 reference

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Preclinical Alzheimer disease: brain oxidative stress, Abeta peptide and proteomics

29 September 2017

1 reference

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Increased levels of 4-hydroxynonenal and acrolein in the brain in preclinical Alzheimer disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646088

Role of oxidative stress in the progression of Alzheimer's disease

29 September 2017

1 reference

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Ethanol withdrawal increases glutathione adducts of 4-hydroxy-2-hexenal but not 4-hydroxyl-2-nonenal in the rat cerebral cortex

29 September 2017

1 reference

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Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling.

29 September 2017

1 reference

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Molecular mechanisms of 4-hydroxy-2-nonenal and acrolein toxicity: nucleophilic targets and adduct formation

29 September 2017

1 reference

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Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake

29 September 2017

1 reference

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Excitatory amino acid transporter 2 associates with phosphorylated tau and is localized in neurofibrillary tangles of tauopathic brains

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646088

Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646088

A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: new insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2)

29 September 2017

1 reference

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Molecular mechanisms of the conjugated alpha,beta-unsaturated carbonyl derivatives: relevance to neurotoxicity and neurodegenerative diseases

29 September 2017

1 reference

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Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease

29 September 2017

1 reference

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Pathologically activated therapeutics for neuroprotection

29 September 2017

1 reference

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Extracellular glutamate concentration in hippocampal slice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646088

Transporters for L-glutamate: an update on their molecular pharmacology and pathological involvement

29 September 2017

1 reference

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F2-isoprostanes in Alzheimer and other neurodegenerative diseases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646088

Altered expression of the glutamate transporter EAAT2b in neurological disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646088

Highly conserved and disease-specific patterns of carboxyterminally truncated Abeta peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646088

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646088

Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646088

Decreased platelet glutamate uptake in patients with amyotrophic lateral sclerosis.

29 September 2017

1 reference

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Astrocyte glutamate transport: review of properties, regulation, and physiological functions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646088

Mild cognitive impairment: clinical characterization and outcome

29 September 2017

1 reference

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The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult rat brain

29 September 2017

1 reference

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Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer's disease is associated with inheritance of APOE4.

29 September 2017

1 reference

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A new family of neurotransmitter transporters: the high-affinity glutamate transporters

29 September 2017

1 reference

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Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

29 September 2017

1 reference

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

29 September 2017

1 reference

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Oxidative stress impairs glutamate uptake in fibroblasts from patients with Alzheimer's disease

29 September 2017

1 reference

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Endothelin-1 decreases glutamate uptake in primary cultured rat astrocytes

27 June 2018

1 reference

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Beneficial effects of dietary restriction on cerebral cortical synaptic terminals: preservation of glucose and glutamate transport and mitochondrial function after exposure to amyloid beta-peptide, iron, and 3-nitropropionic acid.

27 June 2018

1 reference

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Neurotrophic factors protect cortical synaptic terminals against amyloid and oxidative stress-induced impairment of glucose transport, glutamate transport and mitochondrial function

27 June 2018

1 reference

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Interindividual differences in the levels of the glutamate transporters GLAST and GLT, but no clear correlation with Alzheimer's disease

27 June 2018

1 reference

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Elevated 4-Hydroxynonenal in Ventricular Fluid in Alzheimer’s Disease

27 June 2018

1 reference

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4-Hydroxynonenal, a product of lipid peroxidation, inhibits dephosphorylation of the microtubule-associated protein tau

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646088

Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: role of the lipid peroxidation product 4-hydroxynonenal

27 June 2018

1 reference

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A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide

27 June 2018

1 reference

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Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease

27 June 2018

1 reference

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Region-specific loss of glutamate innervation in Alzheimer's disease.

27 June 2018

1 reference

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Sodium dependent D-[3H]aspartate binding in cerebral cortex in patients with Alzheimer's and Parkinson's diseases

27 June 2018

1 reference

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Astrocyte glutamate uptake during chemical hypoxia in vitro

27 June 2018

1 reference

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Redox Proteomics Analysis of Brains from Subjects with Amnestic Mild Cognitive Impairment Compared to Brains from Subjects with Preclinical Alzheimer's Disease: Insights into Memory Loss in MCI

27 June 2018

1 reference

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Trans-4-hydroxy-2-hexenal is a neurotoxic product of docosahexaenoic (22:6; n-3) acid oxidation

5 September 2018

1 reference

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Loss of VGLUT1 and VGLUT2 in the prefrontal cortex is correlated with cognitive decline in Alzheimer disease

5 September 2018

1 reference

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Alterations in expression of glutamatergic transporters and receptors in sporadic Alzheimer's disease.

5 September 2018

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Neuropathologic substrate of mild cognitive impairment

5 September 2018

1 reference

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Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646088

Acrolein inhibits NADH-linked mitochondrial enzyme activity: implications for Alzheimer's disease

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646088

The identification and characterization of oxidized RNAs in Alzheimer's disease.

5 September 2018

1 reference

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Effects of estrogen treatment on glutamate uptake in cultured human astrocytes derived from cortex of Alzheimer's disease patients

5 September 2018

1 reference

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Increased oxidative stress in Alzheimer's disease as assessed with 4-hydroxynonenal but not malondialdehyde

5 September 2018

1 reference

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Oxidative damage is the earliest event in Alzheimer disease

5 September 2018

1 reference

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The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer's disease brain: the role of Abeta1-42.

5 September 2018

1 reference

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Glutamate uptake is decreased in platelets from Alzheimer's disease patients.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646088

Neuronal RNA oxidation in Alzheimer's disease and Down's syndrome.

5 September 2018

1 reference

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Four-Hydroxynonenal, a Product of Lipid Peroxidation, is Increased in the Brain in Alzheimer’s Disease

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646088

4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646088

Glutamate Transporter Alterations in Alzheimer Disease Are Possibly Associated with Abnormal APP Expression

5 September 2018

1 reference

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beta-Amyloid peptide-derived, oxygen-dependent free radicals inhibit glutamate uptake in cultured astrocytes: implications for Alzheimer's disease.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3646088

Acrolein, a product of lipid peroxidation, inhibits glucose and glutamate uptake in primary neuronal cultures

5 September 2018

1 reference

12 December 2020

Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay

1 reference

12 December 2020

4-Hydroxyhexenal: a lipid peroxidation product derived from oxidized docosahexaenoic acid

1 reference

12 December 2020

Amyloid beta peptide (25-35) inhibits Na -dependent glutamate uptake in rat hippocampal astrocyte cultures

1 reference

12 December 2020

Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease

1 reference

12 December 2020

17?-Estradiol attenuates oxidative impairment of synaptic Na /K -ATPase activity, glucose transport, and glutamate transport induced by amyloid ?-peptide and iron

1 reference

12 December 2020

Identifiers

DOI

10.3233/JAD-2012-120409

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=22766736

5 January 2025

1 reference

16 August 2017

1 reference