Signal transduction pathways that contribute to myeloid differentiation (Q36795284)

16 August 2017

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title

Signal transduction pathways that contribute to myeloid differentiation (English)

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16 August 2017

Miranda MB

1

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16 August 2017

Johnson DE

series ordinal

2

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16 August 2017

publication date

19 April 2007

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16 August 2017

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16 August 2017

volume

21

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16 August 2017

issue

7

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16 August 2017

page(s)

1363-1377

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Constitutive uncoupling of pathways of gene expression that control growth and differentiation in myeloid leukemia: a model for the origin and progression of malignancy

16 August 2017

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Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.

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Regulation of granulopoiesis by transcription factors and cytokine signals

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Transcriptional regulation of granulocyte and monocyte development

21 January 2018

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Role of transcription factors C/EBPalpha and PU.1 in normal hematopoiesis and leukemia.

21 January 2018

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PU.1: An ETS family transcription factor that regulates leukemogenesis besides normal hematopoiesis

21 January 2018

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Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia

21 January 2018

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Importance of MEK-1/-2 signaling in monocytic and granulocytic differentiation of myeloid cell lines

21 January 2018

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Cytokine-induced myeloid differentiation is dependent on activation of the MEK/ERK pathway

21 January 2018

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STATs: signal transducers and activators of transcription

21 January 2018

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STAT family of transcription factors in cytokine-mediated biological responses

21 January 2018

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STATs and Gene Regulation

21 January 2018

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21 January 2018

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STAT signalling in cell proliferation and in development

21 January 2018

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Dimerization of cell surface receptors in signal transduction

21 January 2018

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JAKs, STATs and Src kinases in hematopoiesis

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Activation of the Jak3 pathway is associated with granulocytic differentiation of myeloid precursor cells

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Mechanisms associated with IL-6-induced up-regulation of Jak3 and its role in monocytic differentiation

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Control of myeloid differentiation and survival by Stats

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2404690

The role of STATs in myeloid differentiation and leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Involvement of STAT3 in the Granulocyte Colony-stimulating Factor-induced Differentiation of Myeloid Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Ser727/Tyr701-phosphorylated Stat1 is required for the regulation of c-Myc, cyclins, and p27Kip1 associated with ATRA-induced G0/G1 arrest of U-937 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Retinoic acid-induced cell cycle arrest of human myeloid cell lines is associated with sequential down-regulation of c-Myc and cyclin E and posttranscriptional up-regulation of p27(Kip1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

New insights into the interaction of Ras with the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Myeloid cell transformation by ras-containing murine sarcoma viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b)

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Inhibition of ras-induced proliferation and cellular transformation by p16INK4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Regulation of p53 stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

High-Intensity Raf Signal Causes Cell Cycle Arrest Mediated by p21Cip1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21Cip1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Mammalian Ras interacts directly with the serine/threonine kinase Raf

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Critical Tyrosine Residues Regulate the Enzymatic and Biological Activity of Raf-1 Kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

The ins and outs of Raf kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Protein kinase C alpha activates RAF-1 by direct phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Retinoic acid causes MEK-dependent RAF phosphorylation through RARalpha plus RXR activation in HL-60 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Raf-1 signaling is required for the later stages of 1,25-dihydroxyvitamin D3-induced differentiation of HL60 cells but is not mediated by the MEK/ERK module

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Biochemical and biological analysis of Mek1 phosphorylation site mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

A Role for the MEK/MAPK Pathway in PMA-Induced Cell Cycle Arrest: Modulation of Megakaryocytic Differentiation of K562 Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Activation of extracellular signal-regulated kinases (ERKs) defines the first phase of 1,25-dihydroxyvitamin D3-induced differentiation of HL60 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Retinoids and myelomonocytic growth factors cooperatively activate RARA and induce human myeloid leukemia cell differentiation via MAP kinase pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Regulation of C/EBPbeta isoforms by MAPK pathways in HL60 cells induced to differentiate by 1,25-dihydroxyvitamin D3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Phosphorylation of C/EBPalpha inhibits granulopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Differential activation of apoptosis regulatory pathways during monocytic vs granulocytic differentiation: a requirement for Bcl-X(L)and XIAP in the prolonged survival of monocytic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

New insights into the control of MAP kinase pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Mammalian MAP kinase signalling cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Activation and signaling of the p38 MAP kinase pathway

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Signal transduction by the JNK group of MAP kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Inhibition of p38MAP kinase potentiates the JNK/SAPK pathway and AP-1 activity in monocytic but not in macrophage or granulocytic differentiation of HL60 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Induction of HL-60 cell differentiation by the p38 mitogen-activated protein kinase inhibitor SB203580 is mediated through the extracellular signal-regulated kinase signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to arsenic trioxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Role of the p38 mitogen-activated protein kinase pathway in the generation of arsenic trioxide-dependent cellular responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Different roles of p38 MAPK and ERK in STI571-induced multi-lineage differentiation of K562 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

CCAAT/enhancer binding protein epsilon: changes in function upon phosphorylation by p38 MAP kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type I interferons and transforming growth factor-beta on normal hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Mitochondrial targeting of JNK/SAPK in the phorbol ester response of myeloid leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Translational study of vitamin D differentiation therapy of myeloid leukemia: effects of the combination with a p38 MAPK inhibitor and an antioxidant.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Tyrosine 763 of the murine granulocyte colony-stimulating factor receptor mediates Ras-dependent activation of the JNK/SAPK mitogen-activated protein kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Regulation of protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Requirement for caspase activation in monocytic differentiation of myeloid leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Granulocyte colony-stimulating factor-induced activation of protein kinase-C in myeloid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Ras signaling enhances the activity of C/EBP alpha to induce granulocytic differentiation by phosphorylation of serine 248.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Activation of protein kinase C delta by all-trans-retinoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Cytokine-mediated protein kinase C activation is a signal for lineage determination in bipotential granulocyte macrophage colony-forming cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Protein kinase C-mediated phosphorylation of the leukemia-associated HOXA9 protein impairs its DNA binding ability and induces myeloid differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Cellular functions regulated by Src family kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Active and inactive protein kinases: structural basis for regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Palmitoylation of p59fyn is reversible and sufficient for plasma membrane association

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Tyr527 is phosphorylated in pp60c-src: implications for regulation

21 January 2018

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https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Src kinase regulation by phosphorylation and dephosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

The interplay between Src family kinases and receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Not so strange bedfellows: G-protein-coupled receptors and Src family kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Src tyrosine kinase is a novel direct effector of G proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Activation of Stat3 preassembled with platelet-derived growth factor beta receptors requires Src kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

STAT5b, a Mediator of Synergism between c-Src and the Epidermal Growth Factor Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Catalytic activity of the mouse guanine nucleotide exchanger mSOS is activated by Fyn tyrosine protein kinase and the T-cell antigen receptor in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

The interplay between Src and integrins in normal and tumor biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Stimulation of the platelet-derived growth factor beta receptor signaling pathway activates protein kinase C-delta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Src family kinases phosphorylate protein kinase C delta on tyrosine residues and modify the neoplastic phenotype of skin keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Identification of a new adapter protein that may link the common beta subunit of the receptor for granulocyte/macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 to phosphatidylinositol 3-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Tyrosine kinase signalling in breast cancer: epidermal growth factor receptor and c-Src interactions in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Lyn and Fgr protein-tyrosine kinases prevent apoptosis during retinoic acid-induced granulocytic differentiation of HL-60 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Differentiation of myeloid cells is accompanied by increased levels of pp60c-src protein and kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Early signaling pathways activated by c-Kit in hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Involvement of Shc and Cbl-PI 3-kinase in Lyn-dependent proliferative signaling pathways for G-CSF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

G-CSF-induced tyrosine phosphorylation of Gab2 is Lyn kinase dependent and associated with enhanced Akt and differentiative, not proliferative, responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Requirement of Src kinase Lyn for induction of DNA synthesis by granulocyte colony-stimulating factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

The phosphoinositide 3-kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer.

21 January 2018

1 reference

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The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking

21 January 2018

1 reference

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hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase

21 January 2018

1 reference

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Novel PtdIns(3)P-binding protein Etf1 functions as an effector of the Vps34 PtdIns 3-kinase in autophagy

21 January 2018

1 reference

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Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit

21 January 2018

1 reference

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Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

p120cbl is a cytosolic adapter protein that associates with phosphoinositide 3-kinase in response to epidermal growth factor in PC12 and other cells

21 January 2018

1 reference

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The PI3K-PDK1 connection: more than just a road to PKB

21 January 2018

1 reference

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The protein kinase B/Akt signalling pathway in human malignancy

21 January 2018

1 reference

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Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

1 reference

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

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NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

21 January 2018

1 reference

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Akt participation in the Wnt signaling pathway through Dishevelled

21 January 2018

1 reference

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HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

21 January 2018

1 reference

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p90-RSK and Akt may promote rapid phosphorylation/inactivation of glycogen synthase kinase 3 in chemoattractant-stimulated neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Activation of the p70 S6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

AKT pathway is activated by 1, 25-dihydroxyvitamin D3 and participates in its anti-apoptotic effect and cell cycle control in differentiating HL60 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Purification and initial characterization of a type beta transforming growth factor from human placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Expression cloning and characterization of the TGF-beta type III receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Receptor-associated Mad homologues synergize as effectors of the TGF-beta response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

A human Mad protein acting as a BMP-regulated transcriptional activator

21 January 2018

1 reference

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Hierarchical model of gene regulation by transforming growth factor beta

21 January 2018

1 reference

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Smad8 mediates the signaling of the ALK-2 [corrected] receptor serine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Smad6 inhibits signalling by the TGF-β superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Stimulation of granulopoiesis by transforming growth factor beta: synergy with granulocyte/macrophage-colony-stimulating factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Smad5 is dispensable for adult murine hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Bone morphogenetic proteins regulate the developmental program of human hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Smad7 alters cell fate decisions of human hematopoietic repopulating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Smad7 promotes self-renewal of hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Levels of phospho-Smad2/3 are sensors of the interplay between effects of TGF-beta and retinoic acid on monocytic and granulocytic differentiation of HL-60 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

The role of microRNAs in normal hematopoiesis and hematopoietic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

MicroRNAs: regulators of gene expression and cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

p19ARF links the tumour suppressor p53 to Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

Granulocyte colony-stimulating factor and its receptor in normal hematopoietic cell development and myeloid disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

7 January 2021

Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells

1 reference

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7 January 2021

Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

7 January 2021

STAT3-mediated differentiation and survival and of myeloid cells in response to granulocyte colony-stimulating factor: role for the cyclin-dependent kinase inhibitor p27(Kip1)

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

7 January 2021

STAT3beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription

1 reference

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7 January 2021

Granulocyte colony-stimulating factor activates a 72-kDa isoform of STAT3 in human neutrophils

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

7 January 2021

A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

7 January 2021

The Ras superfamily of GTPases.

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

7 January 2021

Function and regulation of ras.

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

7 January 2021

Oncogenic RAS genes impair erythroid differentiation of erythroleukaemia cells

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

7 January 2021

H-, K- and N-Ras inhibit myeloid leukemia cell proliferation by a p21WAF1-dependent mechanism

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

7 January 2021

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

7 January 2021

Effects of deregulated Raf activation on integrin, cytokine-receptor expression and the induction of apoptosis in hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

7 January 2021

Identification of a mouse p21Cdc42/Rac activated kinase

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

7 January 2021

Inhibition of p38 MAP kinase activity up-regulates multiple MAP kinase pathways and potentiates 1,25-dihydroxyvitamin D(3)-induced differentiation of human leukemia HL60 cells

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

7 January 2021

Differential effects of phorbol ester on signaling and gene expression in human leukemia cells

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

7 January 2021

Activation of protein kinase C relays distinct signaling pathways in the same cell type: differentiation and caspase-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

7 January 2021

Lineage commitment of transformed haematopoietic progenitors is determined by the level of PKC activity.

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

7 January 2021

Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

7 January 2021

G Protein-coupled Chemoattractant Receptors Regulate Lyn Tyrosine Kinase·Shc Adapter Protein Signaling Complexes

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

7 January 2021

Purification and properties of a type beta transforming growth factor from bovine kidney

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

7 January 2021

p21(cip1) mRNA is controlled by endogenous transforming growth factor-beta1 in quiescent human hematopoietic stem/progenitor cells

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

7 January 2021

Differentiation induction of HL60 cells by 1,25(OH)2D3, all trans retinoic acid, rTGF-beta2 and their combinations

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

7 January 2021

Transforming growth factor-beta1 is an autocrine mediator of U937 cell growth arrest and differentiation induced by vitamin D3 and retinoids

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

7 January 2021

The interconversion of protein phosphatase 2A between PP2A1 and PP2A0 during retinoic acid-induced granulocytic differentiation and a modification on the catalytic subunit in S phase of HL-60 cells

1 reference

https://api.crossref.org/works/10.1038/SJ.LEU.2404690

7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2404690

1 reference

16 August 2017

1 reference