Amyloid-beta aggregation (Q36788949)

16 August 2017

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title

Amyloid-beta aggregation (English)

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16 August 2017

Verena H Finder

1

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16 August 2017

Rudi Glockshuber

series ordinal

2

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16 August 2017

publication date

1 January 2007

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Neurodegenerative Diseases

16 August 2017

published in

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16 August 2017

volume

4

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16 August 2017

issue

1

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16 August 2017

page(s)

13-27

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

16 August 2017

cites work

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Opinion: What is the role of protein aggregation in neurodegeneration?

21 January 2018

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Protein folding and misfolding

21 January 2018

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A century of Alzheimer's disease

21 January 2018

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Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

21 January 2018

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Amyloid beta-peptide is produced by cultured cells during normal metabolism

21 January 2018

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

21 January 2018

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The p38 MAP kinase signaling pathway in Alzheimer's disease.

21 January 2018

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APP gene family. Alternative splicing generates functionally related isoforms

21 January 2018

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Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases

21 January 2018

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

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Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

21 January 2018

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Mouse models of Alzheimer's disease: insight into treatment

21 January 2018

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

21 January 2018

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Genetically engineered mouse models of neurodegenerative diseases

21 January 2018

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An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

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Structure of beta-amyloid fibrils and its relevance to their neurotoxicity: implications for the pathogenesis of Alzheimer's disease.

21 January 2018

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Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau.

21 January 2018

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Mutations in the Tau gene cause frontotemporal dementia.

21 January 2018

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Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

21 January 2018

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Unfolding the role of protein misfolding in neurodegenerative diseases

21 January 2018

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100 years and counting: prospects for defeating Alzheimer's disease

21 January 2018

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Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

21 January 2018

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Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

21 January 2018

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Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

21 January 2018

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Alzheimer's disease is a synaptic failure

21 January 2018

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

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Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition

21 January 2018

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

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Increased Abeta42(43) from cell lines expressing presenilin 1 mutations.

21 January 2018

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Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains

21 January 2018

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Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

21 January 2018

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Evolution of amyloid: what normal protein folding may tell us about fibrillogenesis and disease

21 January 2018

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Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

21 January 2018

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Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

21 January 2018

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A specific amyloid-beta protein assembly in the brain impairs memory

21 January 2018

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Alzheimer's disease and Abeta toxicity: from top to bottom

21 January 2018

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A detergent-insoluble membrane compartment contains A beta in vivo

21 January 2018

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Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons

21 January 2018

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Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

21 January 2018

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Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways

21 January 2018

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Solution structure of amyloid beta-peptide(1-40) in a water-micelle environment. Is the membrane-spanning domain where we think it is?

21 January 2018

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Solution structure of the Alzheimer amyloid beta-peptide (1-42) in an apolar microenvironment. Similarity with a virus fusion domain

21 January 2018

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The Alzheimer's peptide a beta adopts a collapsed coil structure in water

21 January 2018

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Solution Structures of β Peptide and Its Constituent Fragments: Relation to Amyloid Deposition

21 January 2018

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On the nucleation of amyloid beta-protein monomer folding

21 January 2018

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Conformational transition of amyloid beta-peptide

21 January 2018

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Soluble Amyloid Aβ-(1–40) Exists as a Stable Dimer at Low Concentrations

21 January 2018

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Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease beta A4 peptides

21 January 2018

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Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease

21 January 2018

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Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture

21 January 2018

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A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization

21 January 2018

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Soluble multimeric Alzheimer beta(1-40) pre-amyloid complexes in dilute solution.

21 January 2018

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Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease

21 January 2018

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Alzheimer's beta-peptide oligomer formation at physiologic concentrations

21 January 2018

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Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers

21 January 2018

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Self-assembly of Abeta(1-42) into globular neurotoxins.

21 January 2018

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Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease

21 January 2018

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

21 January 2018

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Assembly of A beta amyloid protofibrils: an in vitro model for a possible early event in Alzheimer's disease

21 January 2018

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Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease

21 January 2018

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The channel hypothesis of Alzheimer's disease: current status

21 January 2018

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Neurodegenerative disease: amyloid pores from pathogenic mutations

21 January 2018

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Amyloid ion channels: a common structural link for protein-misfolding disease

21 January 2018

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Neuronal and glial calcium signaling in Alzheimer's disease

21 January 2018

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Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins

21 January 2018

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Abeta protofibrils possess a stable core structure resistant to hydrogen exchange

21 January 2018

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Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

21 January 2018

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Structural properties of Abeta protofibrils stabilized by a small molecule.

21 January 2018

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Amyloid fibrillogenesis: themes and variations

21 January 2018

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Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro

21 January 2018

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Structure and morphology of the Alzheimer's amyloid fibril

21 January 2018

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A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR

21 January 2018

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Photoaffinity cross-linking of Alzheimer's disease amyloid fibrils reveals interstrand contact regions between assembled beta-amyloid peptide subunits

21 January 2018

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Supramolecular structural constraints on Alzheimer's beta-amyloid fibrils from electron microscopy and solid-state nuclear magnetic resonance.

21 January 2018

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3D structure of Alzheimer's amyloid-beta(1-42) fibrils

21 January 2018

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Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils

21 January 2018

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21 January 2018

The state of the prion

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Molecular biology of Alzheimer's disease

21 January 2018

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Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

21 January 2018

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Structural and kinetic features of amyloid beta-protein fibrillogenesis

21 January 2018

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Protofibril formation of amyloid beta-protein at low pH via a non-cooperative elongation mechanism.

21 January 2018

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beta-amyloid is different in normal aging and in Alzheimer disease.

21 January 2018

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Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

21 January 2018

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On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants

21 January 2018

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Seeding specificity in amyloid growth induced by heterologous fibrils

21 January 2018

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The amyloid beta peptide (Abeta(1-40)) is thermodynamically soluble at physiological concentrations

21 January 2018

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Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein

21 January 2018

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Kinetic theory of fibrillogenesis of amyloid β-protein

21 January 2018

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Thermodynamics of A beta(1-40) amyloid fibril elongation

21 January 2018

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Fibrillogenesis of synthetic amyloid-beta peptides is dependent on their initial secondary structure

21 January 2018

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Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis

21 January 2018

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Direct observation of Abeta amyloid fibril growth and inhibition

21 January 2018

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Molecular recycling within amyloid fibrils

21 January 2018

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Alzheimer's Aβ(1–42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

21 January 2018

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Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules

21 January 2018

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Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

21 January 2018

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Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

21 January 2018

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Expression of beta-amyloid precursor protein-CD3gamma chimeras to demonstrate the selective generation of amyloid beta(1-40) and amyloid beta(1-42) peptides within secretory and endocytic compartments

21 January 2018

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Cytosolic and nuclear aggregation of the amyloid beta-peptide following its expression in the endoplasmic reticulum.

21 January 2018

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Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture

21 January 2018

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Intraneuronal Abeta42 accumulation in human brain.

21 January 2018

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A familial Alzheimer's disease locus on chromosome 1.

21 January 2018

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

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Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease

21 January 2018

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

21 January 2018

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A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

21 January 2018

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Disease modifying strategies for the treatment of Alzheimer's disease targeted at modulating levels of the beta-amyloid peptide

21 January 2018

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21 January 2018

Amyloid double trouble.

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Effects of the mutations Glu22 to Gln and Ala21 to Gly on the aggregation of a synthetic fragment of the Alzheimer's amyloid beta/A4 peptide.

21 January 2018

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The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

21 January 2018

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In vitro studies of Flemish, Dutch, and wild-type beta-amyloid provide evidence for two-staged neurotoxicity

21 January 2018

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Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores.

21 January 2018

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Sequence determinants of enhanced amyloidogenicity of Alzheimer A{beta}42 peptide relative to A{beta}40.

21 January 2018

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Neurodegenerative diseases and oxidative stress

21 January 2018

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The metallobiology of Alzheimer's disease

21 January 2018

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Amyloid-β: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-β

21 January 2018

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An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript

21 January 2018

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Metal ions, pH, and cholesterol regulate the interactions of Alzheimer's disease amyloid-beta peptide with membrane lipid

21 January 2018

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Metals and amyloid-beta in Alzheimer's disease

21 January 2018

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Copper, iron and zinc in Alzheimer's disease senile plaques

21 January 2018

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Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors.

21 January 2018

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Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

21 January 2018

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Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice

21 January 2018

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Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

21 January 2018

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The critical role of methionine 35 in Alzheimer's amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity

21 January 2018

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Methionine oxidation by reactive oxygen species: reaction mechanisms and relevance to Alzheimer's disease

21 January 2018

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Methionine 35 oxidation reduces fibril assembly of the amyloid abeta-(1-42) peptide of Alzheimer's disease

21 January 2018

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Oxidation of methionine 35 attenuates formation of amyloid beta -peptide 1-40 oligomers

21 January 2018

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

21 January 2018

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Characterization of stable complexes involving apolipoprotein E and the amyloid beta peptide in Alzheimer's disease brain.

21 January 2018

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A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

21 January 2018

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Susceptibility gene(s) for Alzheimer's disease on chromosome 10.

21 January 2018

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Accelerated Abeta aggregation in the presence of GM1-ganglioside-accumulated synaptosomes of aged apoE4-knock-in mouse brain

21 January 2018

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Aggregation and secondary structure of synthetic amyloid beta A4 peptides of Alzheimer's disease

21 January 2018

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Physical, morphological and functional differences between ph 5.8 and 7.4 aggregates of the Alzheimer's amyloid peptide Abeta

21 January 2018

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Aggregation State and Neurotoxic Properties of Alzheimer Beta-Amyloid Peptide

21 January 2018

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Temperature dependence of amyloid beta-protein fibrillization

21 January 2018

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Enhanced pathologic properties of Dutch-type mutant amyloid beta-protein

21 January 2018

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Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

21 January 2018

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beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease

21 January 2018

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Neuritic plaque amyloid in Alzheimer's disease is highly racemized

21 January 2018

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Irreversible dimerization/tetramerization and post-translational modifications inhibit proteolytic degradation of A beta peptides of Alzheimer's disease

21 January 2018

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Close-meshed prevalence rates of different stages as a tool to uncover the rate of Alzheimer's disease-related neurofibrillary changes.

21 January 2018

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Towards Alzheimer's disease vaccination

21 January 2018

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Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease

21 January 2018

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Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease

21 January 2018

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Short amyloid-beta (Abeta) immunogens reduce cerebral Abeta load and learning deficits in an Alzheimer's disease mouse model in the absence of an Abeta-specific cellular immune response.

21 January 2018

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

21 January 2018

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Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

21 January 2018

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Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68.

21 January 2018

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Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

21 January 2018

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Drug discovery in dementia: the role of rodent models

21 January 2018

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Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity

21 January 2018

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Specific spatial learning deficits become severe with age in beta -amyloid precursor protein transgenic mice that harbor diffuse beta -amyloid deposits but do not form plaques

21 January 2018

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A biotechnological method provides access to aggregation competent monomeric Alzheimer's 1-42 residue amyloid peptide

21 January 2018

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Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

21 January 2018

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Fractionation and characterization of oligomeric, protofibrillar and fibrillar forms of beta-amyloid peptide

21 January 2018

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The Alzheimer β-peptide shows temperature-dependent transitions between left-handed 31-helix, β-strand and random coil secondary structures

21 January 2018

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The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

21 January 2018

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21 January 2018

Identifiers

DOI

10.1159/000100355

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16 August 2017

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