The cost of living in the membrane: a case study of hydrophobic mismatch for the multi-segment protein LeuT. (Q36781347)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23376428 AND SRC:MED&resulttype=core&format=json

23 February 2020

title

The cost of living in the membrane: a case study of hydrophobic mismatch for the multi-segment protein LeuT (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23376428 AND SRC:MED&resulttype=core&format=json

23 February 2020

1 reference

1

1 reference

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23 February 2020

Lei Shi

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23376428 AND SRC:MED&resulttype=core&format=json

23 February 2020

Harel Weinstein

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23376428 AND SRC:MED&resulttype=core&format=json

23 February 2020

author name string

George Khelashvili

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23376428 AND SRC:MED&resulttype=core&format=json

23 February 2020

publication date

30 January 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23376428 AND SRC:MED&resulttype=core&format=json

Chemistry and Physics of Lipids

23 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23376428 AND SRC:MED&resulttype=core&format=json

23 February 2020

volume

169

1 reference

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23 February 2020

page(s)

27-38

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23376428 AND SRC:MED&resulttype=core&format=json

Ligand-dependent conformations and dynamics of the serotonin 5-HT(2A) receptor determine its activation and membrane-driven oligomerization properties

23 February 2020

cites work

1 reference

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Experimental conditions can obscure the second high-affinity site in LeuT.

29 September 2017

1 reference

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Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context

29 September 2017

1 reference

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X-ray structures of LeuT in substrate-free outward-open and apo inward-open states

29 September 2017

1 reference

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Quantitative Modeling of Membrane Deformations by Multihelical Membrane Proteins: Application to G-Protein Coupled Receptors

29 September 2017

1 reference

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Insights into transport mechanism from LeuT engineered to transport tryptophan

29 September 2017

1 reference

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Thiazolidinedione insulin sensitizers alter lipid bilayer properties and voltage-dependent sodium channel function: implications for drug discovery

29 September 2017

1 reference

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Side-chain hydrophobicity scale derived from transmembrane protein folding into lipid bilayers

29 September 2017

1 reference

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Substrate-modulated gating dynamics in a Na -coupled neurotransmitter transporter homologue

29 September 2017

1 reference

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Anisotropic Solvent Model of the Lipid Bilayer. 2. Energetics of Insertion of Small Molecules, Peptides, and Proteins in Membranes

29 September 2017

1 reference

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Substrate specificity and ion coupling in the Na /betaine symporter BetP

29 September 2017

1 reference

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The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter

29 September 2017

1 reference

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Molecular simulations of dodecyl-β-maltoside micelles in water: influence of the headgroup conformation and force field parameters

29 September 2017

1 reference

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Conformational rearrangements to the intracellular open states of the LeuT and ApcT transporters are modulated by common mechanisms

29 September 2017

1 reference

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Modeling and dynamics of the inward-facing state of a Na /Cl- dependent neurotransmitter transporter homologue

29 September 2017

1 reference

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Substrate and drug binding sites in LeuT.

29 September 2017

1 reference

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Contribution of Membrane Elastic Energy to Rhodopsin Function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters.

29 September 2017

1 reference

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Update of the CHARMM all-atom additive force field for lipids: validation on six lipid types

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Single-molecule dynamics of gating in a neurotransmitter transporter homologue

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Modeling membrane deformations and lipid demixing upon protein-membrane interaction: the BAR dimer adsorption.

29 September 2017

1 reference

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Structure and Mechanism of a Na -Independent Amino Acid Transporter

29 September 2017

1 reference

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CHARMM-GUI Membrane Builder for mixed bilayers and its application to yeast membranes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Emerging roles for lipids in shaping membrane-protein function.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

CHARMM: the biomolecular simulation program

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Structural and dynamic effects of cholesterol at preferred sites of interaction with rhodopsin identified from microsecond length molecular dynamics simulations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

A competitive inhibitor traps LeuT in an open-to-out conformation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Lipid-rhodopsin hydrophobic mismatch alters rhodopsin helical content

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

The binding sites for cocaine and dopamine in the dopamine transporter overlap

29 September 2017

1 reference

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A continuum method for determining membrane protein insertion energies and the problem of charged residues

29 September 2017

1 reference

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Lateral pressure profile, spontaneous curvature frustration, and the incorporation and conformation of proteins in membranes

29 September 2017

1 reference

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Antidepressant binding site in a bacterial homologue of neurotransmitter transporters

29 September 2017

1 reference

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On the thermodynamic stability of a charged arginine side chain in a transmembrane helix

29 September 2017

1 reference

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Bilayer thickness and membrane protein function: an energetic perspective.

29 September 2017

1 reference

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Curvature and hydrophobic forces drive oligomerization and modulate activity of rhodopsin in membranes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

A role for direct interactions in the modulation of rhodopsin by omega-3 polyunsaturated lipids.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

OPM: orientations of proteins in membranes database

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Scalable molecular dynamics with NAMD

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Crystal structure of a bacterial homologue of Na /Cl--dependent neurotransmitter transporters

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

How did the neurotransmitter cross the bilayer? A closer view

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Phosphatidylethanolamine-phosphatidylglycerol bilayer as a model of the inner bacterial membrane

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Cholesterol-induced protein sorting: an analysis of energetic feasibility

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Effect of chain length and unsaturation on elasticity of lipid bilayers

29 September 2017

1 reference

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A functional-phylogenetic system for the classification of transport proteins

29 September 2017

1 reference

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Theoretical analysis of hydrophobic matching and membrane-mediated interactions in lipid bilayers containing gramicidin

29 September 2017

1 reference

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Experimental evidence for hydrophobic matching and membrane-mediated interactions in lipid bilayers containing gramicidin

29 September 2017

1 reference

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Spring constants for channel-induced lipid bilayer deformations. Estimates using gramicidin channels

29 September 2017

1 reference

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Energetics of Inclusion-Induced Bilayer Deformations

29 September 2017

1 reference

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Free-energy determinants of alpha-helix insertion into lipid bilayers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

VMD: visual molecular dynamics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Comparative protein modelling by satisfaction of spatial restraints

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Modulation of rhodopsin function by properties of the membrane bilayer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Simple Allosteric Model for Membrane Pumps

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Deformation free energy of bilayer membrane and its effect on gramicidin channel lifetime

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Enzymology, genetics, and regulation of membrane phospholipid synthesis in Escherichia coli

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Membrane bending is critical for the stability of voltage sensor segments in the membrane

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Molecular basis for membrane phospholipid diversity: why are there so many lipids?

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Characterization of membrane-protein interactions for the leucine transporter from Aquifex aeolicus by molecular dynamics calculations.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

The mechanism of a neurotransmitter:sodium symporter--inward release of Na and substrate is triggered by substrate in a second binding site

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

X-ray diffraction measurement of the monolayer spontaneous curvature of dioleoylphosphatidylglycerol

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Energetics of hydrophobic matching in lipid-protein interactions

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Capsaicin regulates voltage-dependent sodium channels by altering lipid bilayer elasticity.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Role of cholesterol and polyunsaturated chains in lipid-protein interactions: molecular dynamics simulation of rhodopsin in a realistic membrane environment.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Snorkeling of lysine side chains in transmembrane helices: how easy can it get?

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Hydrophobic coupling of lipid bilayer energetics to channel function.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Elastic deformation of membrane bilayers probed by deuterium NMR relaxation

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Conformational energetics of rhodopsin modulated by nonlamellar-forming lipids

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Neurotransmitter transporters as molecular targets for addictive drugs.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Lipid shape is a key factor for membrane interactions of amphipathic helical peptides

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3631462

Structure of fully hydrated fluid phase lipid bilayers with monounsaturated chains

4 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23376428

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23376428

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

G Protein-Coupled Receptors Self-Assemble in Dynamics Simulations of Model Bilayers

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23376428

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CHEMPHYSLIP.2013.01.006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23376428 AND SRC:MED&resulttype=core&format=json

23 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23376428 AND SRC:MED&resulttype=core&format=json

23 February 2020

PubMed publication ID

23376428

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23376428 AND SRC:MED&resulttype=core&format=json