PGC-1α Promotes Ureagenesis in Mouse Periportal Hepatocytes through SIRT3 and SIRT5 in Response to Glucagon (Q36774381)

16 August 2017

PGC-1α Promotes Ureagenesis in Mouse Periportal Hepatocytes through SIRT3 and SIRT5 in Response to Glucagon (English)

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16 August 2017

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Lulu Li

1

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16 August 2017

Ping Zhang

2

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16 August 2017

Zhengxi Bao

3

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16 August 2017

Tongxin Wang

4

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16 August 2017

Shuang Liu

5

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16 August 2017

Feiruo Huang

6

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16 August 2017

language of work or name

English

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publication date

7 April 2016

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16 August 2017

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16 August 2017

6

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16 August 2017

24156

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SIRT5 is under the control of PGC-1α and AMPK and is involved in regulation of mitochondrial energy metabolism

16 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823758

UCP2 regulates the glucagon response to fasting and starvation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823758

Metformin reduces hepatic expression of SIRT3, the mitochondrial deacetylase controlling energy metabolism

29 September 2017

1 reference

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Mitochondrial protein acylation and intermediary metabolism: regulation by sirtuins and implications for metabolic disease

29 September 2017

1 reference

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Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823758

Sirt3 Promotes the Urea Cycle and Fatty Acid Oxidation during Dietary Restriction

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823758

Nutrient-dependent regulation of PGC-1alpha's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5

29 September 2017

1 reference

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Transcription dynamics in a physiological process: β-catenin signaling directs liver metabolic zonation

29 September 2017

1 reference

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SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle

29 September 2017

1 reference

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Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression

29 September 2017

1 reference

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Neurological implications of urea cycle disorders

29 September 2017

1 reference

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Hepatocellular expression of glutamine synthetase: an indicator of morphogen actions as master regulators of zonation in adult liver

29 September 2017

1 reference

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SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

29 September 2017

1 reference

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Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling

29 September 2017

1 reference

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Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

29 September 2017

1 reference

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Pathophysiology of hepatic encephalopathy: a new look at ammonia

29 September 2017

1 reference

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Regulation of enzymes of the urea cycle and arginine metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823758

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

29 September 2017

1 reference

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New perspectives into the molecular pathogenesis and treatment of type 2 diabetes

29 September 2017

1 reference

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Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

29 September 2017

1 reference

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Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux

29 September 2017

1 reference

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Coordinate induction of the urea cycle enzymes by glucagon and dexamethasone is accomplished by three different mechanisms

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823758

Nitrogen metabolism and ornithine cycle function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823758

Hepatocyte Heterogeneity in the Metabolism of Amino Acids and Ammonia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823758

Amino Acid Metabolism in Man

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823758

Heterogeneous reciprocal localization of fructose-1,6-bis-phosphatase and of glucokinase in microdissected periportal and perivenous rat liver tissue

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823758

Caloric restriction alters the feeding response of key metabolic enzyme genes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823758

L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase

27 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823758

Induction of the five urea-cycle enzymes by glucagon in cultured foetal rat hepatocytes

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823758

The use of perfusion of liver and other organs for the study of microsomal electron-transport and cytochrome P-450 systems

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823758

Ammonia detoxification via ureagenesis in rat hepatocytes involves mitochondrial aquaporin-8 channels

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823758

Urea cycle regulation by mitochondrial sirtuin, SIRT5.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823758

Overexpression of SIRT5 confirms its involvement in deacetylation and activation of carbamoyl phosphate synthetase 1.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823758

Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823758

Zonal gene expression in murine liver: lessons from tumors

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823758

Susceptibility of murine periportal hepatocytes to hypoxia-reoxygenation: role for NO and Kupffer cell-derived oxidants

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823758

PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823758

A window into cellular metabolism: hepatic metabolism of (15)N-labelled substrates

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823758

Differential effects of fasting and protein-free diets on levels of urea cycle enzymes in rat liver

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823758

Alanine metabolism in the perfused rat liver. Studies with (15)N.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4823758

Induction of urea cycle enzymes of rat liver by glucagon

12 August 2018

1 reference

12 December 2020

Hepatocellular heterogeneity in ammonia metabolism: demonstration of limited colocalization of carbamoylphosphate synthetase and glutamine synthetase

1 reference

12 December 2020

Regulation of [15N]urea synthesis from [5-15N]glutamine. Role of pH, hormones, and pyruvate

1 reference

12 December 2020

GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha

1 reference

12 December 2020

Differential gene expression in periportal and perivenous mouse hepatocytes

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12 December 2020

Identifiers

DOI

10.1038/SREP24156

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16 August 2017

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16 August 2017

PubMed publication ID

27052737

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