Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma. (Q36757025)

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scientific article published on 5 May 2015

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English	Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma.	scientific article published on 5 May 2015

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7 March 2020

Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma (English)

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7 March 2020

metastatic melanoma

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Philip D Gregory

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Nicholas P. Restifo

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Gary Lee

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Matthew Mendel

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Mary Black

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Nimisha Gandhi

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Zhiya Yu

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Martin Giedlin

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Jeff Miller

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Michael C Holmes

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Molecular Therapy

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1380-1390

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7 March 2020

IL-2: the first effective immunotherapy for human cancer.

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PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors

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Tumor-specific cytolysis by lymphocytes infiltrating human melanomas

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