Structure-activity relationships for G2 checkpoint inhibition by caffeine analogs. (Q36709879)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10762633 AND SRC:MED&resulttype=core&format=json

5 November 2019

title

Structure-activity relationships for G2 checkpoint inhibition by caffeine analogs (English)

1 reference

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5 November 2019

author name string

X Jiang

1

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5 November 2019

L Y Lim

2

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5 November 2019

J W Daly

3

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5 November 2019

A H Li

4

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5 November 2019

K A Jacobson

5

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5 November 2019

M Roberge

6

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5 November 2019

publication date

1 May 2000

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International Journal of Oncology

5 November 2019

published in

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5 November 2019

volume

16

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5 November 2019

issue

5

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5 November 2019

page(s)

971-978

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Caffeine inhibits the checkpoint kinase ATM

5 November 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

p53 regulates a G2 checkpoint through cyclin B1

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Inhibition of radiation-induced G2 delay potentiates cell death by apoptosis and/or the induction of giant cells in colorectal tumor cells with disrupted p53 function

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Cell cycle checkpoints: preventing an identity crisis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

DNA damage and cell cycle checkpoints

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Cell cycle checkpoints, genetic instability and cancer.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Chromosome condensation induced by fostriecin does not require p34cdc2 kinase activity and histone H1 hyperphosphorylation, but is associated with enhanced histone H2A and H3 phosphorylation.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Differential sensitivity of p53(-) and p53( ) cells to caffeine-induced radiosensitization and override of G2 delay.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Cell Cycle Checkpoints, Genomic Integrity, and Cancer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Mechanism by which caffeine potentiates lethality of nitrogen mustard

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Effect of caffeine on radiation-induced mitotic delay: delayed expression of G2 arrest

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Effects of caffeine on radiation-induced phenomena associated with cell-cycle traverse of mammalian cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

The effect of caffeine on X-ray-induced mitotic delay in normal human and ataxia-telangiectasia fibroblasts

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

The pharmacology of caffeine.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Caffeine and theophylline analogues: correlation of behavioral effects with activity as adenosine receptor antagonists and as phosphodiesterase inhibitors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Caffeine analogs: structure-activity relationships at adenosine receptors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Creative blocks: cell-cycle checkpoints and feedback controls

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

High-throughput assay for G2 checkpoint inhibitors and identification of the structurally novel compound isogranulatimide.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Structural basis for specificity and potency of xanthine derivatives as activators of the CFTR chloride channel.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Cytotoxic, cell cycle, and chromosomal effects of methylxanthines in human tumor cells treated with alkylating agents

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Override of the radiation-induced mitotic block in human tumour cells by methylxanthines and its relationship to the potentiation of cytotoxicity

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Checkpoint Pathways Come of Age

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Preferential radiosensitization of G1 checkpoint-deficient cells by methylxanthines.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4801034

Activities of caffeine, theophylline, and enprofylline analogs as tracheal relaxants

5 September 2018

1 reference

12 December 2020

Selective radiosensitization of p53-deficient cells by caffeine-mediated activation of p34cdc2 kinase

1 reference

12 December 2020

Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors

1 reference

12 December 2020

Structure-activity relationship of xanthines and skeletal muscle ryanodine receptor/Ca2 release channel

1 reference

12 December 2020

Stimulation of calcium release by caffeine analogs in pheochromocytoma cells

1 reference

12 December 2020

Role of wild type p53 in the G2 phase: regulation of the γirradiation-induced delay and DNA repair

1 reference

12 December 2020

Identifiers

DOI

10.3892/IJO.16.5.971

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10762633 AND SRC:MED&resulttype=core&format=json

5 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10762633 AND SRC:MED&resulttype=core&format=json

5 November 2019

PubMed publication ID

10762633

1 reference