P110α-mediated constitutive PI3K signaling limits the efficacy of p110δ-selective inhibition in mantle cell lymphoma, particularly with multiple relapse (Q36709839)

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scientific article published on 22 January 2013

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English	P110α-mediated constitutive PI3K signaling limits the efficacy of p110δ-selective inhibition in mantle cell lymphoma, particularly with multiple relapse	scientific article published on 22 January 2013

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22 February 2020

P110α-mediated constitutive PI3K signaling limits the efficacy of p110δ-selective inhibition in mantle cell lymphoma, particularly with multiple relapse (English)

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22 February 2020

mantle cell lymphoma

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22 February 2020

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Sunil Iyengar

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22 February 2020

Andrew Clear

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22 February 2020

Lenushka Maharaj

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22 February 2020

Abigail Lee

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22 February 2020

Maria Calaminici

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22 February 2020

Janet Matthews

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22 February 2020

Sameena Iqbal

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22 February 2020

Rebecca Auer

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22 February 2020

John Gribben

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22 February 2020

Simon Joel

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22 February 2020

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22 January 2013

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22 February 2020

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22 February 2020

121

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22 February 2020

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22 February 2020

2274-2284

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22 February 2020

The miRNA-17∼92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3606064

30 September 2017

A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3606064

30 September 2017

CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3606064

30 September 2017

Mantle cell lymphoma: biology, pathogenesis, and the molecular basis of treatment in the genomic era

1 reference

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30 September 2017

The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3606064

30 September 2017

The emerging mechanisms of isoform-specific PI3K signalling

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30 September 2017

PIKing the right isoform: the emergent role of the p110beta subunit in breast cancer.

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30 September 2017

Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors

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30 September 2017

Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3606064

30 September 2017

Phosphatidylinositol 3'-kinase catalytic subunit alpha gene amplification contributes to the pathogenesis of mantle cell lymphoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3606064

30 September 2017

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

1 reference

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30 September 2017

Styryl sulfonyl compounds inhibit translation of cyclin D1 in mantle cell lymphoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3606064

30 September 2017

Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3606064

30 September 2017

GSK-3beta inhibition: at the crossroad between Akt and mTOR constitutive activation to enhance cyclin D1 protein stability in mantle cell lymphoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3606064

30 September 2017

PTEN-deficient cancers depend on PIK3CB.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3606064

30 September 2017

The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3606064

30 September 2017

Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3606064

30 September 2017

Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3606064

30 September 2017

Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3606064

30 September 2017

Pathogenesis of mantle-cell lymphoma: all oncogenic roads lead to dysregulation of cell cycle and DNA damage response pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3606064

30 September 2017

Comparison of phosphatidylinositol-3-kinase signalling within a panel of human colorectal cancer cell lines with mutant or wild-type PIK3CA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3606064

30 September 2017

PI 3-kinase p110beta: a new target for antithrombotic therapy

1 reference

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30 September 2017

Signalling by PI3K isoforms: insights from gene-targeted mice.

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30 September 2017

High frequency of mutations of the PIK3CA gene in human cancers

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30 September 2017

PI3K in lymphocyte development, differentiation and activation

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30 September 2017

Signaling by distinct classes of phosphoinositide 3-kinases

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30 September 2017

p110δ, a novel phosphoinositide 3-kinase in leukocytes

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30 September 2017

PI3K signalling: the path to discovery and understanding.

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5 September 2018

Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma

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5 September 2018

Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells

1 reference

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5 September 2018

Gene expression profiling of mantle cell lymphoma cells reveals aberrant expression of genes from the PI3K-AKT, WNT and TGFbeta signalling pathways.

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5 September 2018

Genomic and Gene Expression Profiling Defines Indolent Forms of Mantle Cell Lymphoma

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4 December 2018

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Progress in mantle-cell lymphoma

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12 December 2020

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