Optogenetic Silencing of Nav1.8-Positive Afferents Alleviates Inflammatory and Neuropathic Pain (Q36693619)

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31 March 2020

title

Optogenetic Silencing of Nav1.8-Positive Afferents Alleviates Inflammatory and Neuropathic Pain (English)

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31 March 2020

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2

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Jeffrey S Wieskopf

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31 March 2020

author name string

Ihab Daou

1

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Ariel R Ase

3

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Alfredo Ribeiro-da-Silva

5

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Jeffrey S Mogil

6

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Philippe Séguéla

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publication date

1 January 2016

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31 March 2020

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volume

3

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issue

1

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Sodium channel Nav1.8: Emerging links to human disease

31 March 2020

cites work

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A novel analgesic approach to optogenetically and specifically inhibit pain transmission using TRPV1 promoter

30 September 2017

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Virally mediated optogenetic excitation and inhibition of pain in freely moving nontransgenic mice

30 September 2017

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A gain-of-function voltage-gated sodium channel 1.8 mutation drives intense hyperexcitability of A- and C-fiber neurons

30 September 2017

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Genetically encoded molecular tools for light-driven silencing of targeted neurons

30 September 2017

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Antisense-mediated knockdown of Na(V)1.8, but not Na(V)1.9, generates inhibitory effects on complete Freund's adjuvant-induced inflammatory pain in rat.

30 September 2017

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High-performance genetically targetable optical neural silencing by light-driven proton pumps

30 September 2017

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A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.

30 September 2017

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Neuropathic pain develops normally in mice lacking both Na(v)1.7 and Na(v)1.8.

30 September 2017

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Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

30 September 2017

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A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing

28 June 2018

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Remote optogenetic activation and sensitization of pain pathways in freely moving mice.

28 June 2018

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Involvement of the TTX-resistant sodium channel Nav 1.8 in inflammatory and neuropathic, but not post-operative, pain states

5 September 2018

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Ambroxol, a Nav1.8-preferring Na( ) channel blocker, effectively suppresses pain symptoms in animal models of chronic, neuropathic and inflammatory pain

5 September 2018

1 reference

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The role of Na(V)1.8 sodium channel in the maintenance of chronic inflammatory hypernociception

5 September 2018

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Nociceptor-specific gene deletion using heterozygous NaV1.8-Cre recombinase mice

5 September 2018

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Deficits in visceral pain and referred hyperalgesia in Nav1.8 (SNS/PN3)-null mice.

5 September 2018

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The Cell and Molecular Basis of Mechanical, Cold, and Inflammatory Pain

5 September 2018

1 reference

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Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system

4 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27022626

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1523/ENEURO.0140-15.2016

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31 March 2020

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31 March 2020

PubMed publication ID

27022626

1 reference