The mouse as a model for human biology: a resource guide for complex trait analysis (Q36685876)

15 August 2017

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title

The mouse as a model for human biology: a resource guide for complex trait analysis (English)

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15 August 2017

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3

Carol J Bult

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15 August 2017

1

Luanne L Peters

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15 August 2017

5

Beverly J Paigen

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15 August 2017

4

Gary A Churchill

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15 August 2017

6

Karen L Svenson

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15 August 2017

Raymond F Robledo

2

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15 August 2017

publication date

1 January 2007

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15 August 2017

published in

Nature Reviews Genetics

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15 August 2017

volume

8

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15 August 2017

issue

1

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15 August 2017

page(s)

58-69

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The nature and identification of quantitative trait loci: a community's view

15 August 2017

cites work

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ENU mutagenesis: a work in progress

21 January 2018

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Large-scale, high-throughput screening for coagulation and hematologic phenotypes in mice.

21 January 2018

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Initial sequencing and comparative analysis of the mouse genome

21 January 2018

1 reference

Investigating gene function using mouse models

31 March 2020

1 reference

Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse

31 March 2020

1 reference

The Mouse Phenome Project

31 March 2020

1 reference

A collaborative database of inbred mouse strain characteristics

31 March 2020

1 reference

31 March 2020

A mouse phenome project

1 reference

EMPReSS: standardized phenotype screens for functional annotation of the mouse genome.

31 March 2020

1 reference

Abnormal splicing of the leptin receptor in diabetic mice

31 March 2020

1 reference

Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice

31 March 2020

1 reference

Positional cloning of the mouse obese gene and its human homologue

31 March 2020

1 reference

Purkinje cell degeneration associated with erythroid ankyrin deficiency in nb/nb mice

31 March 2020

1 reference

Of mice and men: the mice were right

31 March 2020

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440-kD ankyrinB: structure of the major developmentally regulated domain and selective localization in unmyelinated axons

31 March 2020

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nm1054: a spontaneous, recessive, hypochromic, microcytic anemia mutation in the mouse

31 March 2020

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Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells

31 March 2020

1 reference

Mouse models of genetic disease: new approaches, new paradigms.

31 March 2020

1 reference

Implementing large-scale ENU mutagenesis screens in North America

31 March 2020

1 reference

N-ethyl-N-nitrosourea mutagenesis: boarding the mouse mutant express

31 March 2020

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Genome-wide, large-scale production of mutant mice by ENU mutagenesis.

31 March 2020

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31 March 2020

Mouse ENU mutagenesis

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Sequence interpretation. Functional annotation of mouse genome sequences

31 March 2020

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Recombinant-inbred strains. An aid to finding identity, linkage, and function of histocompatibility and other genes

31 March 2020

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Recombinant Inbred Lines: Value in the Genetic Analysis of Biochemical Variants

31 March 2020

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A new set of BXD recombinant inbred lines from advanced intercross populations in mice

31 March 2020

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Genetic structure of the LXS panel of recombinant inbred mouse strains: a powerful resource for complex trait analysis

31 March 2020

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Strategies for mapping and cloning quantitative trait genes in rodents

31 March 2020

1 reference

Genome-wide genetic association of complex traits in heterogeneous stock mice

31 March 2020

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Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains

31 March 2020

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A genome-wide set of congenic mouse strains derived from DBA/2J on a C57BL/6J background

31 March 2020

1 reference

Genome-tagged mice (GTM): two sets of genome-wide congenic strains

31 March 2020

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Analysing complex genetic traits with chromosome substitution strains

31 March 2020

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Chromosome-wise dissection of the genome of the extremely big mouse line DU6i

31 March 2020

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Chromosome substitution strains: some quantitative considerations for genome scans and fine mapping

31 March 2020

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Germ line integration and Mendelian transmission of the exogenous Moloney leukemia virus

31 March 2020

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Targetted correction of a mutant HPRT gene in mouse embryonic stem cells

31 March 2020

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Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

31 March 2020

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Conditional alleles in mice: practical considerations for tissue-specific knockouts

31 March 2020

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The knockout mouse project

31 March 2020

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31 March 2020

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Bioinformatics toolbox for narrowing rodent quantitative trait loci

31 March 2020

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Bioinformatics in the post-sequence era.

31 March 2020

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Connecting sequence and biology in the laboratory mouse

31 March 2020

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Integrated pathway–genome databases and their role in drug discovery

31 March 2020

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The Ensembl genome database project

31 March 2020

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The UCSC Genome Browser Database: update 2006

31 March 2020

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The UCSC Table Browser data retrieval tool

31 March 2020

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The Mouse Genome Database (MGD): integrating biology with the genome.

31 March 2020

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The Mouse Genome Database (MGD): from genes to mice--a community resource for mouse biology

31 March 2020

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WormBase: a multi-species resource for nematode biology and genomics

31 March 2020

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The Vertebrate Genome Annotation (Vega) database

31 March 2020

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Mouse Phenome Project: understanding human biology through mouse genetics and genomics

31 March 2020

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Comparative analysis of haplotype association mapping algorithms

31 March 2020

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Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse

31 March 2020

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Introducing the German Mouse Clinic: open access platform for standardized phenotyping.

31 March 2020

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Systematic, standardized and comprehensive neurological phenotyping of inbred mice strains in the German Mouse Clinic.

31 March 2020

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Maps from two interspecific backcross DNA panels available as a community genetic mapping resource

31 March 2020

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Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse

31 March 2020

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An efficient SNP system for mouse genome scanning and elucidating strain relationships.

31 March 2020

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Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse

31 March 2020

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Insights from human/mouse genome comparisons

31 March 2020

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Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci

31 March 2020

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Identifying novel genes for atherosclerosis through mouse-human comparative genetics

31 March 2020

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Unraveling the genetics of chronic kidney disease using animal models

31 March 2020

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Genetics of variation in HDL cholesterol in humans and mice

31 March 2020

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Genome-wide search for new genes controlling plasma lipid concentrations in mice and humans

31 March 2020

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Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility

31 March 2020

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Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans

31 March 2020

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Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

31 March 2020

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From QTL to gene: the harvest begins

31 March 2020

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The mosaic structure of variation in the laboratory mouse genome

31 March 2020

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Segmental phylogenetic relationships of inbred mouse strains revealed by fine-scale analysis of sequence variation across 4.6 mb of mouse genome

31 March 2020

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Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse

31 March 2020

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Identification of quantitative trait loci that modify the severity of hereditary spherocytosis in wan, a new mouse model of band-3 deficiency

31 March 2020

1 reference

Genetic modification of hearing in tubby mice: evidence for the existence of a major gene (moth1) which protects tubby mice from hearing loss

31 March 2020

1 reference

Quantitative trait loci for baseline erythroid traits.

31 March 2020

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Quantitative trait loci for baseline white blood cell count, platelet count, and mean platelet volume.

31 March 2020

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Association of mean platelet volume with risk of stroke among 3134 individuals with history of cerebrovascular disease

31 March 2020

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White blood cell count as a predictor of mortality: results over 18 years from the Normative Aging Study

31 March 2020

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Mean platelet volume and myocardial infarction

31 March 2020

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Influence of platelet size on outcome after myocardial infarction

31 March 2020

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Prediction of adverse outcomes in children with sickle cell disease

31 March 2020

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The acute chest syndrome of sickle cell disease

31 March 2020

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Mortality in sickle cell disease. Life expectancy and risk factors for early death.

31 March 2020

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Pain in sickle cell disease. Rates and risk factors

31 March 2020

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A simple method to calculate resolving power and confidence interval of QTL map location

31 March 2020

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Conserved synteny in rat and mouse for a blood pressure QTL on human chromosome 17

31 March 2020

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Identification of candidate disease genes by EST alignments, synteny, and expression and verification of Ensembl genes on rat chromosome 1q43-54.

31 March 2020

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Interspecies synteny mapping identifies a quantitative trait locus for bone mineral density on human chromosome Xp22

31 March 2020

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Combining data from multiple inbred line crosses improves the power and resolution of quantitative trait loci mapping

31 March 2020

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Genetic analysis of blood pressure in C3H/HeJ and SWR/J mice

31 March 2020

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Quantitative trait loci that determine BMD in C57BL/6J and 129S1/SvImJ inbred mice

31 March 2020

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Haplotype analysis in multiple crosses to identify a QTL gene

31 March 2020

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Platelet formation is the consequence of caspase activation within megakaryocytes

31 March 2020

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The birth of the platelet

31 March 2020

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Megakaryocytes and beyond: the birth of platelets

31 March 2020

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A role for Rab27b in NF-E2-dependent pathways of platelet formation

31 March 2020

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Review of microarray experimental design strategies for genetical genomics studies

31 March 2020

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Elucidating the murine brain transcriptional network in a segregating mouse population to identify core functional modules for obesity and diabetes

31 March 2020

1 reference

Cis-acting expression quantitative trait loci in mice

31 March 2020

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Integrating genetic and gene expression data: application to cardiovascular and metabolic traits in mice

31 March 2020

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Identification of candidate genes in the type 2 diabetes modifier locus using expression QTL

31 March 2020

1 reference

Simulating the collaborative cross: power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of mice

31 March 2020

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The Collaborative Cross, a community resource for the genetic analysis of complex traits

31 March 2020

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In silico mapping of complex disease-related traits in mice.

31 March 2020

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In silico quantitative trait locus map for atherosclerosis susceptibility in apolipoprotein E-deficient mice

31 March 2020

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Structural model analysis of multiple quantitative traits

31 March 2020

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Using advanced intercross lines for high-resolution mapping of HDL cholesterol quantitative trait loci

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRG2025

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15 August 2017

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