Calpains and their multiple roles in diabetes mellitus (Q36675894)

15 August 2017

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title

Calpains and their multiple roles in diabetes mellitus (English)

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15 August 2017

Frederick Harris

1

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15 August 2017

Suman Biswas

2

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15 August 2017

Jaipaul Singh

3

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15 August 2017

Sarah Dennison

4

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15 August 2017

David A Phoenix

5

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15 August 2017

language of work or name

English

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publication date

1 November 2006

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Annals of the New York Academy of Sciences

15 August 2017

published in

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15 August 2017

volume

1084

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15 August 2017

page(s)

452-480

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Global and societal implications of the diabetes epidemic

15 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

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Genetics of type 2 diabetes mellitus: status and perspectives

21 January 2018

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Genetic control of autoimmunity in Type I diabetes and associated disorders

21 January 2018

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Type 2 diabetes: principles of pathogenesis and therapy

21 January 2018

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Understanding autoimmune diabetes: insights from mouse models.

21 January 2018

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Insulin-dependent diabetes mellitus as an autoimmune disease

21 January 2018

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A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus

21 January 2018

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The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones

21 January 2018

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Insulin resistance and antidiabetic drugs

21 January 2018

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Potential new treatments for type 2 diabetes

21 January 2018

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https://api.crossref.org/works/10.1196/ANNALS.1372.011

Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus

21 January 2018

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https://api.crossref.org/works/10.1196/ANNALS.1372.011

Obesity and liver disease

21 January 2018

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https://api.crossref.org/works/10.1196/ANNALS.1372.011

Polycystic ovary syndrome--a systemic disorder?

21 January 2018

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https://api.crossref.org/works/10.1196/ANNALS.1372.011

Atherosclerosis in type 2 diabetes mellitus and insulin resistance: mechanistic links and therapeutic targets

21 January 2018

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https://api.crossref.org/works/10.1196/ANNALS.1372.011

The role of angiotensin II antagonism in type 2 diabetes mellitus: a review of renoprotection studies

21 January 2018

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https://api.crossref.org/works/10.1196/ANNALS.1372.011

Diabetic retinopathy: more than meets the eye.

21 January 2018

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https://api.crossref.org/works/10.1196/ANNALS.1372.011

Genetics of Type 2 diabetes.

21 January 2018

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https://api.crossref.org/works/10.1196/ANNALS.1372.011

The search for type 2 diabetes genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Linkage of type 2 diabetes to the glucokinase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Calpain-10: from genome search to function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Crystal structure of calpain reveals the structural basis for Ca(2 )-dependent protease activity and a novel mode of enzyme activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Activation of calpain by Ca2 : roles of the large subunit N-terminal and domain III-IV linker peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Domain II of m-calpain is a Ca(2 )-dependent cysteine protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Roles of individual EF-hands in the activation of m-calpain by calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Investigations into the membrane interactions of m-calpain domain V.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

The structure of calcium-free human m-calpain: implications for calcium activation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Structural Basis for Possible Calcium-Induced Activation Mechanisms of Calpains

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Flexibility analysis and structure comparison of two crystal forms of calcium-free human m-calpain

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Contribution of distinct structural elements to activation of calpain by Ca2 ions

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Multiple interactions of the 'transducer' govern its function in calpain activation by Ca2

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Calpain mutants with increased Ca2 sensitivity and implications for the role of the C(2)-like domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

21 January 2018

Calpain-related diseases

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Ca2 dependency of calpain 3 (p94) activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

The calpain family and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Calpain: a protease in search of a function?

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Calpain function in the modulation of signal transduction molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Calpain function in the differentiation of mesenchymal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Ischemic neuronal death in the rat hippocampus: the calpain-calpastatin-caspase hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Calpain inhibition: a therapeutic strategy targeting multiple disease states.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Calpains in muscle wasting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

The pathogenic activation of calpain: a marker and mediator of cellular toxicity and disease states

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Role of calpains in diabetes mellitus: a mini review

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Homozygous combination of calpain 10 gene haplotypes is associated with type 2 diabetes mellitus in a Polish population

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Calpain 10 gene polymorphisms are related, not to type 2 diabetes, but to increased serum cholesterol in Japanese

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Role of calpain-10 gene variants in familial type 2 diabetes in Caucasians

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Genetic variations in calpain-10 gene are not a major factor in the occurrence of type 2 diabetes in Japanese

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Type 2 diabetes and three calpain-10 gene polymorphisms in Samoans: no evidence of association

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Are variants in the CAPN10 gene related to risk of type 2 diabetes? A quantitative assessment of population and family-based association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Candidate genes for type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Genetic prediction of future type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

A statistical method for identification of polymorphisms that explain a linkage result

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Association of calpain-10 gene with microvascular function

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Characterization and expression of calpain 10. A novel ubiquitous calpain with nuclear localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Challenges in identifying genetic variation affecting susceptibility to type 2 diabetes: examples from studies of the calpain-10 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Association of the SNP-19 genotype 22 in the calpain-10 gene with elevated body mass index and hemoglobin A1c levels in Japanese

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Variation in the calpain-10 gene is associated with elevated triglyceride levels and reduced adipose tissue messenger ribonucleic acid expression in obese Swedish subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Insulin resistance, polycystic ovary syndrome, and type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Comment: CAPN10 alleles are associated with polycystic ovary syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Common single nucleotide polymorphisms in intron 3 of the calpain-10 gene influence hirsutism

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Variation within the Type 2 Diabetes Susceptibility Gene Calpain-10 and Polycystic Ovary Syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Role of calpain in adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

The insulin-induced down-regulation of IRS-1 in 3T3-L1 adipocytes is mediated by a calcium-dependent thiol protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Downregulation of IRS-1 protein in thapsigargin-treated human prostate epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Calpain-10 gene polymorphism is associated with reduced beta(3)-adrenoceptor function in human fat cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Polymorphism in the Calpain 10 gene influences glucose metabolism in human fat cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Insulin granule dynamics in pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Inhibition of calpain blocks pancreatic beta-cell spreading and insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

SNAREs and the specificity of membrane fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

SNARE complex structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

SNARE-mediated membrane fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Mechanisms of intracellular protein transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Evidence that an isoform of calpain-10 is a regulator of exocytosis in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Interaction of calpastatin with calpain: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Calpain system regulates muscle mass and glucose transporter GLUT4 turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Calpain facilitates GLUT4 vesicle translocation during insulin-stimulated glucose uptake in adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

GLUT4 expression in 3T3-L1 adipocytes is repressed by proteasome inhibition, but not by inhibition of calpains

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Type 2 diabetes mellitus: a cardiovascular perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Endothelial dysfunction in type 2 diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Diabetic state-induced regulation of glucose uptake to skeletal muscle by insulin: a possible mechanism of its enhancement and autoinhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Changes in membrane microenvironment and signal transduction in platelets from NIDDM patients-a pilot study

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Endothelial dysfunction, inflammation and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Diabetes and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Somatostatin increases glucocorticoid binding and signaling in macrophages by blocking the calpain-specific cleavage of Hsp 90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Protein for Lp82 calpain is expressed and enzymatically active in young rat lens

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Biochemical properties of lens-specific calpain Lp85.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Pharmacological prevention of diabetic cataract

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Redox regulation in the lens

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Advanced glycation: an important pathological event in diabetic and age related ocular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Contribution of ubiquitous calpains to cataractogenesis in the spontaneous diabetic WBN/Kob rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Lp82 is the dominant form of calpain in young mouse lens

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Defining a link between gap junction communication, proteolysis, and cataract formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Differential influence of proteolysis by calpain 2 and Lp82 on in vitro precipitation of mouse lens crystallins

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Release of alpha-A sequence 158-173 correlates with a decrease in the molecular chaperone properties of native alpha-crystallin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Purification and characterization of lens specific calpain (Lp82) from bovine lens

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Human-mouse differences in the embryonic expression patterns of developmental control genes and disease genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Tracking pathology with proteomics: identification of in vivo degradation products of alphaB-crystallin

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Activation of Calpain in Lens: A Review and Proposed Mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

The in vitro retardation of porcine cataractogenesis by the calpain inhibitor, SJA6017.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

alpha-Crystallin chaperone function in diabetic rat and human lenses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

No evidence for involvement of the calpain-10 gene `high-risk' haplotype combination for non-insulin-dependent diabetes mellitus in early onset obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1196/ANNALS.1372.011

21 January 2018

Identifiers

DOI

10.1196/ANNALS.1372.011

1 reference

15 August 2017

1 reference