Nonenzymatic role for WRN in preserving nascent DNA strands after replication stress. (Q36664165)

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24 February 2020

title

Nonenzymatic role for WRN in preserving nascent DNA strands after replication stress (English)

1 reference

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24 February 2020

author

Souparno Bhattacharya

5

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24 February 2020

author name string

Fengtao Su

1

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24 February 2020

Shibani Mukherjee

2

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24 February 2020

Yanyong Yang

3

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24 February 2020

Eiichiro Mori

4

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24 February 2020

Junya Kobayashi

6

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24 February 2020

Steven M Yannone

7

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24 February 2020

David J Chen

8

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24 February 2020

Aroumougame Asaithamby

9

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24 February 2020

publication date

6 November 2014

1 reference

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24 February 2020

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24 February 2020

volume

9

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24 February 2020

issue

4

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24 February 2020

page(s)

1387-1401

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DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

24 February 2020

cites work

1 reference

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Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition

30 September 2017

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Distinct functions of human RECQ helicases WRN and BLM in replication fork recovery and progression after hydroxyurea-induced stalling.

30 September 2017

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A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.

30 September 2017

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Topoisomerase I poisoning results in PARP-mediated replication fork reversal

30 September 2017

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Inhibition of homologous recombination in human cells by targeting RAD51 recombinase

30 September 2017

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The Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structures

30 September 2017

1 reference

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WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes

30 September 2017

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Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.

30 September 2017

1 reference

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The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome

30 September 2017

1 reference

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Pathways of mammalian replication fork restart.

30 September 2017

1 reference

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ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

WRN participates in translesion synthesis pathway through interaction with NBS1

30 September 2017

1 reference

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DNA topoisomerases and their poisoning by anticancer and antibacterial drugs

30 September 2017

1 reference

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Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivity

30 September 2017

1 reference

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WRN mutations in Werner syndrome patients: genomic rearrangements, unusual intronic mutations and ethnic-specific alterations

30 September 2017

1 reference

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Substrate specific stimulation of NEIL1 by WRN but not the other human RecQ helicases

30 September 2017

1 reference

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Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

Counting RAD51 proteins disassembling from nucleoprotein filaments under tension.

30 September 2017

1 reference

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Rad51 overexpression rescues radiation resistance in BRCA2-defective cancer cells

30 September 2017

1 reference

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Low doses of alpha particles do not induce sister chromatid exchanges in bystander Chinese hamster cells defective in homologous recombination

30 September 2017

1 reference

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A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

Novel pro- and anti-recombination activities of the Bloom's syndrome helicase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

Increased chemotherapeutic activity of camptothecin in cancer cells by siRNA-induced silencing of WRN helicase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks

30 September 2017

1 reference

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WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing

30 September 2017

1 reference

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Accumulation of Werner protein at DNA double-strand breaks in human cells

30 September 2017

1 reference

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

30 September 2017

1 reference

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Werner syndrome protein associates with gamma H2AX in a manner that depends upon Nbs1.

30 September 2017

1 reference

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Linkage between Werner syndrome protein and the Mre11 complex via Nbs1.

30 September 2017

1 reference

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WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

WRN interacts physically and functionally with the recombination mediator protein RAD52

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

Werner syndrome diploid fibroblasts are sensitive to 4-nitroquinoline-N-oxide and 8-methoxypsoralen: implications for the disease phenotype.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

Elevated levels of Rad51 recombination protein in tumor cells.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

Ku complex interacts with and stimulates the Werner protein

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

Mutations in the WRN gene in mice accelerate mortality in a p53-null background

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

The essential functions of human Rad51 are independent of ATP hydrolysis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

The premature ageing syndrome protein, WRN, is a 3'-->5' exonuclease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

The Werner syndrome protein is a DNA helicase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicism

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

Mutator phenotype of Werner syndrome is characterized by extensive deletions

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

Werner syndrome protein, the MRE11 complex and ATR: menage-à-trois in guarding genome stability during DNA replication?

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

Werner syndrome protein contains three structure-specific DNA binding domains

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782925

Homologous recombination repair is regulated by domains at the N- and C-terminus of NBS1 and is dissociated with ATM functions

20 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25456133

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hierarchical deterioration of body systems in Werner's syndrome: Implications for normal ageing

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25456133

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELREP.2014.10.025

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25456133 AND SRC:MED&resulttype=core&format=json

24 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25456133 AND SRC:MED&resulttype=core&format=json

24 February 2020

PubMed publication ID

25456133

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25456133 AND SRC:MED&resulttype=core&format=json