Unusual regioselectivity and active site topology of human cytochrome P450 2J2 (Q36648643)

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3 January 2020

title

Unusual regioselectivity and active site topology of human cytochrome P450 2J2 (English)

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3 January 2020

1

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3 January 2020

Darryl C Zeldin

3

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3 January 2020

Patrick Dansette

4

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3 January 2020

author name string

François André

2

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3 January 2020

Daniel Mansuy

5

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3 January 2020

language of work or name

English

0 references

publication date

17 August 2007

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3 January 2020

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3 January 2020

volume

46

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issue

36

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3 January 2020

page(s)

10237-10247

1 reference

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Selective, competitive and mechanism-based inhibitors of human cytochrome P450 2J2.

3 January 2020

cites work

1 reference

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CYP2E1 active site residues in substrate recognition sequence 5 identified by photoaffinity labeling and homology modeling

30 September 2017

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Crystal structure of the human prostacyclin synthase

30 September 2017

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Action of epoxyeicosatrienoic acids on cellular function

30 September 2017

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Structural basis for ligand promiscuity in cytochrome P450 3A4.

30 September 2017

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The ins and outs of cytochrome P450s.

30 September 2017

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Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A.

30 September 2017

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Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2.

30 September 2017

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Endothelium-derived epoxyeicosatrienoic acids and vascular function

30 September 2017

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From endothelium-derived hyperpolarizing factor (EDHF) to angiogenesis: Epoxyeicosatrienoic acids (EETs) and cell signaling.

30 September 2017

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Crystal structure of human cytochrome P450 2D6

30 September 2017

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Structural diversity of human xenobiotic-metabolizing cytochrome P450 monooxygenases

30 September 2017

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Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen

30 September 2017

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Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors

30 September 2017

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Cytochrome p450 in silico: an integrative modeling approach.

30 September 2017

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Structures of cytochrome P450 3A4.

30 September 2017

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Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2

30 September 2017

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Enhancement of cardiac L-type Ca2 currents in transgenic mice with cardiac-specific overexpression of CYP2J2

30 September 2017

1 reference

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Detection, delineation, measurement and display of cavities in macromolecular structures

30 September 2017

1 reference

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Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone

30 September 2017

1 reference

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Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K channels and p42/p44 MAPK pathway

30 September 2017

1 reference

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The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution

30 September 2017

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Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site

30 September 2017

1 reference

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An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution

30 September 2017

1 reference

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Structure of mammalian cytochrome P450 2C5 complexed with diclofenac at 2.1 A resolution: evidence for an induced fit model of substrate binding

30 September 2017

1 reference

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Crystal structure of human cytochrome P450 2C9 with bound warfarin

30 September 2017

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SWISS-MODEL: An automated protein homology-modeling server

30 September 2017

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Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 A resolution: evidence for multiple substrate binding modes

30 September 2017

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Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole

30 September 2017

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Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity

30 September 2017

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Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids.

30 September 2017

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Assessing protein structures with a non-local atomic interaction energy.

30 September 2017

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CYP2J subfamily cytochrome P450s in the gastrointestinal tract: expression, localization, and potential functional significance

30 September 2017

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CYP2J subfamily P450s in the lung: expression, localization, and potential functional significance

30 September 2017

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Errors in protein structures

30 September 2017

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Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart

30 September 2017

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Hepatic epoxide hydrase. Structure-activity relations for substrates and inhibitors

30 September 2017

1 reference

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2377029

Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2377029

Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2377029

Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization.

28 June 2018

1 reference

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Arachidonic acid epoxygenase metabolites stimulate endothelial cell growth and angiogenesis via mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling pathways

20 September 2018

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Cytochrome P450-mediated oxidation of glucuronide derivatives: example of estradiol-17beta-glucuronide oxidation to 2-hydroxy-estradiol-17beta-glucuronide by CYP 2C8.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2377029

Use of molecular simulation for mapping conformational CYP2E1 epitopes

20 September 2018

1 reference

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The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution

20 September 2018

1 reference

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Sequence and structure of epoxide hydrolases: a systematic analysis

20 September 2018

1 reference

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Regioselectivity of CYP2B6: homology modeling, molecular dynamics simulation, docking

20 September 2018

1 reference

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Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes

20 September 2018

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Overexpression of cytochrome P450 CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2377029

Activation of Galpha s mediates induction of tissue-type plasminogen activator gene transcription by epoxyeicosatrienoic acids

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2377029

Cardiac and vascular KATP channels in rats are activated by endogenous epoxyeicosatrienoic acids through different mechanisms

20 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17705402

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Homology modeling of cytochrome P450scc and the mutations for optimal amperometric sensor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17705402

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/BI700876A

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17705402 AND SRC:MED&resulttype=core&format=json

release_czobwuggl5gxjnh2yz5plwstv4

3 January 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/czobwuggl5gxjnh2yz5plwstv4

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17705402 AND SRC:MED&resulttype=core&format=json

3 January 2020

PubMed publication ID

17705402

1 reference