Disease modifying therapy for AD? (Q36640414)

15 August 2017

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title

Disease modifying therapy for AD? (English)

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15 August 2017

Todd E Golde

1

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15 August 2017

language of work or name

English

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publication date

1 November 2006

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Journal of Neurochemistry

15 August 2017

published in

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15 August 2017

volume

99

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15 August 2017

issue

3

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15 August 2017

page(s)

689-707

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Neuronal membrane cholesterol loss enhances amyloid peptide generation

15 August 2017

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Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease

21 January 2018

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Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease

21 January 2018

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Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model

21 January 2018

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Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice

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Intravenous immunoglobulins containing antibodies against beta-amyloid for the treatment of Alzheimer's disease

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Abeta-degrading enzymes: modulators of Alzheimer's disease pathogenesis and targets for therapeutic intervention

21 January 2018

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Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme

21 January 2018

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Cleavage of amyloid beta peptide during constitutive processing of its precursor

21 January 2018

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Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

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Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images.

21 January 2018

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Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology

21 January 2018

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Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears beta-amyloid in a mouse model of Alzheimer disease

21 January 2018

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Structure of tau protein and assembly into paired helical filaments

21 January 2018

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Modeling tau polymerization in vitro: a review and synthesis

21 January 2018

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In vitro polymerization of tau protein monitored by laser light scattering: method and application to the study of FTDP-17 mutants

21 January 2018

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Alzheimer's disease: its proteins and genes

21 January 2018

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Mutations causing neurodegenerative tauopathies

21 January 2018

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Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms

21 January 2018

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Alzheimer disease therapy: can the amyloid cascade be halted?

21 January 2018

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Physiologic and pathologic events mediated by intramembranous and juxtamembranous proteolysis

21 January 2018

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Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease

21 January 2018

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Tau filament formation in transgenic mice expressing P301L tau.

21 January 2018

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https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease.

21 January 2018

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The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs

21 January 2018

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Altered microtubule organization in small-calibre axons of mice lacking tau protein

21 January 2018

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Alzheimer's disease: the amyloid cascade hypothesis

21 January 2018

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

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Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor

21 January 2018

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Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice

21 January 2018

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The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.

21 January 2018

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https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

In vivo effects of ApoE and clusterin on amyloid-beta metabolism and neuropathology

21 January 2018

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https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease.

21 January 2018

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https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

Alternate aggregation pathways of the Alzheimer beta-amyloid peptide. An in vitro model of preamyloid.

21 January 2018

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

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Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

21 January 2018

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Muscle weakness, hyperactivity, and impairment in fear conditioning in tau-deficient mice

21 January 2018

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Metabolic regulation of brain Abeta by neprilysin

21 January 2018

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Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

21 January 2018

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Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

21 January 2018

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Caspase-3-mediated cleavage of PHF-1 tau during apoptosis irrespective of excitotoxicity and oxidative stress: an implication to Alzheimer's disease.

21 January 2018

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Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B

21 January 2018

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Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides

21 January 2018

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Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

21 January 2018

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Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice

21 January 2018

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Amyloid diseases: abnormal protein aggregation in neurodegeneration

21 January 2018

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Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production

21 January 2018

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beta-Amyloid efflux mediated by p-glycoprotein

21 January 2018

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Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice

21 January 2018

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Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer's disease brains

21 January 2018

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21 January 2018

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The disordered neuronal cytoskeleton in Alzheimer's disease

21 January 2018

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Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death

21 January 2018

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Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

21 January 2018

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Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

21 January 2018

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

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Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation

21 January 2018

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The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

21 January 2018

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 January 2018

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Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease

21 January 2018

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

21 January 2018

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Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies

21 January 2018

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Interactions of Alzheimer amyloid-beta peptides with glycosaminoglycans effects on fibril nucleation and growth

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Accelerated filament formation from tau protein with specific FTDP-17 missense mutations.

21 January 2018

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Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

21 January 2018

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From acetylcholine to amyloid: neurotransmitters and the pathology of Alzheimer's disease

21 January 2018

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Cdk5 is a key factor in tau aggregation and tangle formation in vivo

21 January 2018

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Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo

21 January 2018

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Clusterin (apoJ) Alters the Aggregation of Amyloid β-Peptide (Aβ1-42) and Forms Slowly Sedimenting Aβ Complexes That Cause Oxidative Stress

21 January 2018

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Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization

21 January 2018

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The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production

21 January 2018

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CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

21 January 2018

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Cerebral hemorrhage after passive anti-Abeta immunotherapy

21 January 2018

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GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

21 January 2018

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The inflammation-induced pathological chaperones ACT and apo-E are necessary catalysts of Alzheimer amyloid formation

21 January 2018

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Mutant genes in familial Alzheimer's disease and transgenic models

21 January 2018

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Alzheimer's disease: genetic studies and transgenic models

21 January 2018

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Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

21 January 2018

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Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta.

21 January 2018

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Apolipoprotein E4 as a target for developing new therapeutics for Alzheimer's disease

21 January 2018

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A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease

21 January 2018

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Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice.

21 January 2018

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Constitutive overactivation of protein kinase C in guinea pig brain increases alpha-secretory APP processing without decreasing beta-amyloid generation

21 January 2018

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A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice.

21 January 2018

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Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation

21 January 2018

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Tau suppression in a neurodegenerative mouse model improves memory function

21 January 2018

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https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis

21 January 2018

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Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning

21 January 2018

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Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

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Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

21 January 2018

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https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival

21 January 2018

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Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases

21 January 2018

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Safety, tolerability, and changes in amyloid beta concentrations after administration of a gamma-secretase inhibitor in volunteers

21 January 2018

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https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

In vivo reversal of amyloid-beta lesions in rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

21 January 2018

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The molecular genetics of the tauopathies

21 January 2018

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Alzheimer's disease and Abeta toxicity: from top to bottom

21 January 2018

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An important role of heparan sulfate proteoglycan (Perlecan) in a model system for the deposition and persistence of fibrillar A beta-amyloid in rat brain

21 January 2018

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Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

21 January 2018

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Risk of Alzheimer's disease and duration of NSAID use.

21 January 2018

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Apolipoprotein E and Alzheimer disease

21 January 2018

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Biochemical identification of the neutral endopeptidase family member responsible for the catabolism of amyloid beta peptide in the brain.

21 January 2018

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Defects in axonal elongation and neuronal migration in mice with disrupted tau and map1b genes

21 January 2018

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Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial

21 January 2018

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A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

21 January 2018

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Proteolytic mechanisms in amyloid-beta metabolism: therapeutic implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

Deciphering the molecular basis of memory failure in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

Insulin increases CSF Abeta42 levels in normal older adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

Immunology and immunotherapy of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

Number of Abeta inoculations in APP PS1 transgenic mice influences antibody titers, microglial activation, and congophilic plaque levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

A fluid connection: cholesterol and Abeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

BACE2 functions as an alternative alpha-secretase in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

Hormone replacement therapy and incidence of Alzheimer disease in older women: the Cache County Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

Clearing amyloid through the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

The alternative splicing of tau exon 10 and its regulatory proteins CLK2 and TRA2-BETA1 changes in sporadic Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1471-4159.2006.04211.X

10.1111/J.1471-4159.2006.04211.X

21 January 2018

Identifiers

DOI

1 reference

15 August 2017

1 reference