Acidic pH increases airway surface liquid viscosity in cystic fibrosis (Q36618542)

15 August 2017

Acidic pH increases airway surface liquid viscosity in cystic fibrosis (English)

1 reference

15 August 2017

0 references

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26808501 AND SRC:MED&resulttype=core&format=json

11 June 2020

David Stoltz

9

1 reference

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11 June 2020

author name string

Xiao Xiao Tang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26808501 AND SRC:MED&resulttype=core&format=json

11 June 2020

Mark J Hoegger

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26808501 AND SRC:MED&resulttype=core&format=json

11 June 2020

Thomas O Moninger

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26808501 AND SRC:MED&resulttype=core&format=json

11 June 2020

Philip H Karp

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26808501 AND SRC:MED&resulttype=core&format=json

11 June 2020

James D McMenimen

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26808501 AND SRC:MED&resulttype=core&format=json

11 June 2020

Biswa Choudhury

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26808501 AND SRC:MED&resulttype=core&format=json

11 June 2020

Ajit Varki

8

1 reference

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11 June 2020

Michael J Welsh

10

1 reference

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11 June 2020

language of work or name

English

0 references

publication date

25 January 2016

1 reference

Journal of Clinical Investigation

15 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26808501 AND SRC:MED&resulttype=core&format=json

11 June 2020

volume

126

1 reference

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11 June 2020

issue

3

1 reference

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11 June 2020

page(s)

879-891

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26808501 AND SRC:MED&resulttype=core&format=json

Oxidation increases mucin polymer cross-links to stiffen airway mucus gels

11 June 2020

cites work

1 reference

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Origins of cystic fibrosis lung disease

30 September 2017

1 reference

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pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37

30 September 2017

1 reference

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Secretion properties, clearance, and therapy in airway disease

30 September 2017

1 reference

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Cystic fibrosis genetics: from molecular understanding to clinical application

30 September 2017

1 reference

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Hypertonic saline releases the attached small intestinal cystic fibrosis mucus

30 September 2017

1 reference

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A functional anatomic defect of the cystic fibrosis airway

30 September 2017

1 reference

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The buffer capacity of airway epithelial secretions

30 September 2017

1 reference

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Assembly of the respiratory mucin MUC5B: a new model for a gel-forming mucin

30 September 2017

1 reference

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Folding of pig gastric mucin non-glycosylated domains: a discrete molecular dynamics study.

30 September 2017

1 reference

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Neonates with cystic fibrosis have a reduced nasal liquid pH; a small pilot study

30 September 2017

1 reference

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Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways

30 September 2017

1 reference

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Perspectives on mucus properties and formation--lessons from the biochemical world

30 September 2017

1 reference

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Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung

30 September 2017

1 reference

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Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype.

30 September 2017

1 reference

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Sinus hypoplasia precedes sinus infection in a porcine model of cystic fibrosis

30 September 2017

1 reference

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Calcium stabilizes the von Willebrand factor A2 domain by promoting refolding

30 September 2017

1 reference

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Mucous solids and liquid secretion by airways: studies with normal pig, cystic fibrosis human, and non-cystic fibrosis human bronchi

30 September 2017

1 reference

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Hyperviscous airway periciliary and mucous liquid layers in cystic fibrosis measured by confocal fluorescence photobleaching

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs

30 September 2017

1 reference

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Loss of anion transport without increased sodium absorption characterizes newborn porcine cystic fibrosis airway epithelia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Airway mucus function and dysfunction

30 September 2017

1 reference

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Hyposecretion of fluid from tracheal submucosal glands of CFTR-deficient pigs

30 September 2017

1 reference

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Airway surface liquid depth imaged by surface laser reflectance microscopy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

A new role for bicarbonate in mucus formation

30 September 2017

1 reference

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Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children

30 September 2017

1 reference

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Characterization of particle translocation through mucin hydrogels

30 September 2017

1 reference

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Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth

30 September 2017

1 reference

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Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator-dependent bicarbonate secretion

30 September 2017

1 reference

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Analysis of N- and O-linked glycans from glycoproteins using MALDI-TOF mass spectrometry

30 September 2017

1 reference

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Micro- and macrorheology of mucus

30 September 2017

1 reference

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Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs

30 September 2017

1 reference

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Cystic fibrosis: impaired bicarbonate secretion and mucoviscidosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Structure and function of the polymeric mucins in airways mucus.

30 September 2017

1 reference

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Unfractionated heparin reduces the elasticity of sputum from patients with cystic fibrosis.

30 September 2017

1 reference

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X-ray microanalysis of apical fluid in cystic fibrosis airway epithelial cell lines.

30 September 2017

1 reference

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Respiratory tract mucin genes and mucin glycoproteins in health and disease

30 September 2017

1 reference

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Submucosal glands and airway defense

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Altered O-glycosylation and sulfation of airway mucins associated with cystic fibrosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Mucin glycosylation changes in cystic fibrosis lung disease are not manifest in submucosal gland secretions

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Discovery and characterization of sialic acid O-acetylation in group B Streptococcus

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Identification of molecular intermediates in the assembly pathway of the MUC5AC mucin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Abnormal surface liquid pH regulation by cultured cystic fibrosis bronchial epithelium

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Calcium-dependent protein interactions in MUC5B provide reversible cross-links in salivary mucus

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Mucociliary clearance in cystic fibrosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Nebulized heparin in Burkholderia cepacia colonized adult cystic fibrosis patients

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Evidence against the acidification hypothesis in cystic fibrosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Endogenous airway acidification. Implications for asthma pathophysiology

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Terminal glycosylation in cystic fibrosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Different O-glycosylation of respiratory mucin glycopeptides from a patient with cystic fibrosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Genotypic analysis of respiratory mucous sulfation defects in cystic fibrosis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Management of pulmonary disease in patients with cystic fibrosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Antibody diffusion in human cervical mucus

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Subunit interactions and physical properties of bovine gallbladder mucin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Goblet cells secretion and mucogenesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Calcium binding to intestinal goblet cell mucin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Mucociliary clearance in the airways

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Alteration of sulfation of glycoconjugates, but not sulfate transport and intracellular inorganic sulfate content in cystic fibrosis airway epithelial cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Molecular mechanism of product storage and release in mucin secretion. II. The role of extracellular Ca .

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Airway surface pH in subjects with cystic fibrosis

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Concentrated solutions of salivary MUC5B mucin do not replicate the gel-forming properties of saliva

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Altered sialyl- and fucosyl-linkage on mucins in cystic fibrosis patients promotes formation of the sialyl-Lewis X determinant on salivary MUC-5B and MUC-7.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Heterologous expression of delta F508 CFTR results in decreased sialylation of membrane glycoconjugates

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Influence of buffer capacity and pH-dependent rheological properties of respiratory mucus on health effects due to acidic pollution.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Defective acidification of intracellular organelles in cystic fibrosis

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Distinguishing free and anomalous diffusion by rectangular fluorescence recovery after photobleaching: a Monte Carlo study

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

A new role for bicarbonate secretion in cervico-uterine mucus release

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Quantification of periciliary fluid height in human airway biopsies is feasible, but not suitable as a biomarker

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Mucus clearance and lung function in cystic fibrosis with hypertonic saline

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Anionic poly(amino acid)s dissolve F-actin and DNA bundles, enhance DNase activity, and reduce the viscosity of cystic fibrosis sputum.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Elemental composition of airway surface liquid in the pig determined by x-ray microanalysis

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Mucins and their O-Glycans from human bronchial epithelial cell cultures

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

A small molecule CFTR inhibitor produces cystic fibrosis-like submucosal gland fluid secretions in normal airways

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Exhaled breath condensate acidification in acute lung injury.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Acidic pH and increasing [Ca(2 )] reduce the swelling of mucins in primary cultures of human cervical cells

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

pH in expired breath condensate of patients with inflammatory airway diseases

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

An in vitro model of differentiated human airway epithelia. Methods for establishing primary cultures

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Physiological basis of cystic fibrosis: a historical perspective

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Elemental composition of human airway surface fluid in healthy and diseased airways

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Structures and Immunochemical Properties of Oligosaccharides Isolated from Pig Submaxillary Mucins

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

The role of mucous glycoproteins in the rheologic properties of cystic fibrosis sputum

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767348

Inhibition of airway liquid secretion and its effect on the physical properties of airway mucus

20 September 2018

1 reference

12 December 2020

Edetate sodium aerosol in Pseudomonas lung infection in cystic fibrosis.

1 reference

12 December 2020

Rheology of Gastric Mucin Exhibits a pH-Dependent Sol−Gel Transition

1 reference

12 December 2020

The sialylation of bronchial mucins secreted by patients suffering from cystic fibrosis or from chronic bronchitis is related to the severity of airway infection

1 reference

12 December 2020

Profound increase in viscosity and aggregation of pig gastric mucin at low pH

1 reference

12 December 2020

Cation induced changes in the rheological properties of purified mucus glycoprotein gels

1 reference

12 December 2020

Viscosity of human salivary mucins: effect of pH and ionic strength and role of sialic acid

1 reference

12 December 2020

Monosaccharide analysis of glycoconjugates by anion exchange chromatography with pulsed amperometric detection

1 reference

12 December 2020

Glycosylation of sputum mucins is altered in cystic fibrosis patients

1 reference

12 December 2020

Airway mucus in cystic fibrosis

1 reference

12 December 2020

pH- and protein-dependent buffer capacity and viscosity of respiratory mucus. Their interrelationships and influence on health

1 reference

12 December 2020

Physical properties of purified human respiratory mucus glycoproteins: effects of sodium chloride concentration on the aggregation properties and shape

1 reference

12 December 2020

Studies on pulmonary secretions. II. Osmolality and the ionic environment of pulmonary secretions from patients with cystic fibrosis, bronchiectasis, and laryngectomy

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI83922

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26808501 AND SRC:MED&resulttype=core&format=json

11 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26808501 AND SRC:MED&resulttype=core&format=json

11 June 2020

PubMed publication ID

26808501

1 reference