Understanding the physiology of the ageing individual: computational modelling of changes in metabolism and endurance. (Q36596036)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27051508 AND SRC:MED&resulttype=core&format=json

31 March 2020

title

Understanding the physiology of the ageing individual: computational modelling of changes in metabolism and endurance (English)

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31 March 2020

1

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31 March 2020

Tom Kirkwood

2

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31 March 2020

James Bassingthwaighte

3

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31 March 2020

author name string

Johannes H G M van Beek

1

1 reference

15 August 2017

James B Bassingthwaighte

3

1 reference

15 August 2017

1 April 2016

1 reference

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31 March 2020

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31 March 2020

volume

6

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31 March 2020

issue

2

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31 March 2020

page(s)

20150079

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Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome.

31 March 2020

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Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

9 September 2017

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A midlife crisis for the mitochondrial free radical theory of aging

9 September 2017

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Monitoring training status with HR measures: do all roads lead to Rome?

9 September 2017

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Transcription could be the key to the selection advantage of mitochondrial deletion mutants in aging

9 September 2017

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Increased expression of matrix extracellular phosphoglycoprotein (MEPE) in cortical bone of the rat tibia after mechanical loading: identification by oligonucleotide microarray

9 September 2017

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The evolution of genome-scale models of cancer metabolism

9 September 2017

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Computational estimation of tricarboxylic acid cycle fluxes using noisy NMR data from cardiac biopsies

9 September 2017

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9 September 2017

The hallmarks of aging

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Mitonuclear protein imbalance as a conserved longevity mechanism

9 September 2017

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Glucose regulation of load-induced mTOR signaling and ER stress in mammalian heart

9 September 2017

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Predicting the impact of diet and enzymopathies on human small intestinal epithelial cells

9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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9 September 2017

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Simulating the physiology of athletes during endurance sports events: modelling human energy conversion and metabolism

9 September 2017

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Analyzing the Functional Properties of the Creatine Kinase System with Multiscale ‘Sloppy’ Modeling

9 September 2017

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9 September 2017

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Human nutrition, the gut microbiome and the immune system

9 September 2017

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Extending life span by increasing oxidative stress

9 September 2017

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Telomere dysfunction induces metabolic and mitochondrial compromise.

9 September 2017

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Macromolecular deterioration as the ultimate constraint on human lifespan

9 September 2017

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Systems biology of ageing and longevity

9 September 2017

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Large-scale in silico modeling of metabolic interactions between cell types in the human brain

9 September 2017

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Accurate quantification of more than 4000 mouse tissue proteins reveals minimal proteome changes during aging

9 September 2017

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Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice

9 September 2017

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Metabolic networks of longevity

9 September 2017

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Rule-based cell systems model of aging using feedback loop motifs mediated by stress responses

9 September 2017

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Extending healthy life span--from yeast to humans

9 September 2017

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Linking functional decline of telomeres, mitochondria and stem cells during ageing

9 September 2017

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Sitting time and mortality from all causes, cardiovascular disease, and cancer

9 September 2017

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9 September 2017

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The Cardiac Physiome: perspectives for the future

9 September 2017

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Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems--role in ageing and disease

9 September 2017

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Reconstruction and flux analysis of coupling between metabolic pathways of astrocytes and neurons: application to cerebral hypoxia

9 September 2017

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9 September 2017

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Mild mitochondrial uncoupling impacts cellular aging in human muscles in vivo

9 September 2017

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Understanding the odd science of aging

9 September 2017

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The oxidative environment and protein damage.

9 September 2017

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Invited Review: Dynamic exercise performance in Masters athletes: insight into the effects of primary human aging on physiological functional capacity

9 September 2017

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Mechanisms of ageing: public or private?

9 September 2017

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Calorie restriction enhances the expression of key metabolic enzymes associated with protein renewal during aging

9 September 2017

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The Free Radical Theory of Aging Matures

9 September 2017

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Decreased heart rate variability and its association with increased mortality after acute myocardial infarction

9 September 2017

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9 September 2017

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Rudolf Schoenheimer and the concept of the dynamic state of body constituents

9 September 2017

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Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading

9 September 2017

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The lungs as receptor sites for cardiovascular regulation

30 September 2017

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Mitochondrial dysfunction and cell senescence — skin deep into mammalian aging

30 September 2017

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Measuring non-steady-state metabolic fluxes in starch-converting faecal microbiota in vitro

28 June 2018

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Accumulation of defective mitochondria through delayed degradation of damaged organelles and its possible role in the ageing of post-mitotic and dividing cells

28 June 2018

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Nonlinear dynamics in sudden cardiac death syndrome: heartrate oscillations and bifurcations

28 June 2018

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Metabolism: Inflammation keeps old mice healthy.

28 June 2018

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Progressively heterogeneous mismatch of regional oxygen delivery to consumption during graded coronary stenosis in pig left ventricle.

20 September 2018

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A validated model of oxygen uptake and circulatory dynamic interactions at exercise onset in humans.

20 September 2018

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Elevated energy coupling and aerobic capacity improves exercise performance in endurance-trained elderly subjects

20 September 2018

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Exercise efficiency is reduced by mitochondrial uncoupling in the elderly

20 September 2018

1 reference

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Computational quantification of metabolic fluxes from a single isotope snapshot: application to an animal biopsy

20 September 2018

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Television viewing time and mortality: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab).

20 September 2018

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Telomere states and cell fates

20 September 2018

1 reference

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Alterations of Antioxidant Enzymes and Oxidative Damage to Macromolecules in Different Organs of Rats During Aging

20 September 2018

1 reference

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Cerebral blood flow and metabolic rate of oxygen, glucose, lactate, pyruvate, ketone bodies and amino acids.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4759747

The Energetic Paradox of Human Running and Hominid Evolution [and Comments and Reply]

20 September 2018

1 reference

https://api.crossref.org/works/10.1098/RSFS.2015.0079

Identification of nuclear phosphatidylinositol 4,5-bisphosphate-interacting proteins by neomycin extraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1098/RSFS.2015.0079

Inference of dynamical gene-regulatory networks based on time-resolved multi-stimuli multi-experiment data applying NetGenerator V2.0.

21 January 2018

1 reference

https://api.crossref.org/works/10.1098/RSFS.2015.0079

Screen-Based Entertainment Time, All-Cause Mortality, and Cardiovascular Events

21 January 2018

1 reference

https://api.crossref.org/works/10.1098/RSFS.2015.0079

Changes in actin synthesis and alpha-actin-mRNA content in rat muscle during immobilization

21 January 2018

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12 December 2020

Further evidence for age-related deficits in human postural function

1 reference

12 December 2020

Oxidative capacity and ageing in human muscle

1 reference

12 December 2020

The free-radical theory of ageing--older, wiser and still alive: modelling positional effects of the primary targets of ROS reveals new support

1 reference

12 December 2020

A (13)C NMR double-labeling method to quantitate local myocardial O(2) consumption using frozen tissue samples

1 reference

12 December 2020

Identifiers

DOI

10.1098/RSFS.2015.0079

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27051508 AND SRC:MED&resulttype=core&format=json

31 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27051508 AND SRC:MED&resulttype=core&format=json

31 March 2020

PubMed publication ID

27051508

1 reference